| 7 | Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice显示文摘Objective: To evaluate the in vivo antischistosomal activities of the crude extracts of Echinops kebericho Mesfin(E. kebericho) root and Hagenia abyssinica(Bruce) J.F. Gmel(H. abyssinica) flower. Methods: Mice were infected with(150 ± 10) Schistosoma mansoni cercariae by paddling technique. Crude extracts were administered orally for five consecutive days at doses of 300, 600 and 1 200 mg/kg/day along with 200 mg/kg/day praziquantel and 3% tween 80 given as a control. Results: E. kebericho root extract showed a statistically significant(P < 0.05) reduction in fecal egg count of 64.44%, 42.96% & 26.82% and worm burden of 65.71%, 47.86% & 31.43% at treatment doses of 1 200 mg/kg/day, 600 mg/kg/day and 300 mg/kg/day, respectively. Similarly, H. abyssinica flower extracts showed a significant(P < 0.05) reduction in fecal egg count up to 84.57%, 77.06% & 63.89% and worm burden of 91.43%, 81.43% & 70.71% at a respective dose levels. In addition, a significant(P < 0.05) reduction in liver granuloma score was observed in all H. abyssinica administered dose groups and E. kebericho at 1 200 mg/kg/day dose group as compared to infected untreated control group. Conclusions: H. abyssinica and E. kebericho crude extracts show a promising antischistosomal activity. | Yonas Alemu Zeleke Mekonnen Ahmed Zeynudin Moti Yohannes Abdissa Biruksew Sultan Suleman | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员