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| 1 | Potential predictive factors for pathologic complete response after the neoadjuvant treatment of rectal adenocarcinoma:a single center experience显示文摘Objective:To assess the response rate of patients with rectal adenocarcinoma to neoadjuvant therapy and to identify the predictors of histological regression after neoadjuvant radiotherapy(RT)or concurrent chemoradiotherapy(CCRT).Methods:This study recruited 64 patients.The patients had resectable cancer of the lower and the middle rectum(T3/T4 and/or N+)without distant metastasis and received neoadjuvant RT or CCRT followed by radical surgery with total mesorectal excision(TME)between January 2006 and December 2011.The patients were classified into non-response(NR),partial response(PR),and pathologic complete response(p CR)based on the Dworak tumor regression grading system.Results:The median age of patients was 57 years(ranging from 22 to 85).A total of 24 patients were treated with neoadjuvant CCRT,whereas 40 patients were treated with RT alone.Abdominoperineal resection(APR)was performed on 29 patients(45%).Anterior resection with TME was performed on 34 patients(53%).One patient had local resection.Histologically,12(19%),24(73%),and 28(44%)patients exhibited p CR,PR,and NR,respectively.Univariate analysis revealed that the predictors of tumor regression were as follows:the absence of lymph node involvement from initial imaging(c N0)(P=0.021);normal initial carcinoembryonic antigen(CEA)level(P=0.01);hemoglobin level≥12 g/dl(P=0.009);CCRT(P=0.021);and tumor downstaging in imaging(P=0.001).Multivariate analysis showed that the main predictors of p CR were CT combined with neoadjuvant RT,c N0stage,and tumor regression on imaging.Conclusions:Identifying the predictors of p CR following neoadjuvant therapy aids the selection of responsive patients for nonaggressive surgical treatment and possible surveillance. | Feryel Letaief Meher Nasri Mouna Ayadi Khedija Meddeb Amina Mokrani Yosra Yahyaoui Nesrine Chraiet Henda Raies Amel Mezlini | 2017 | Cancer Biology & Medicine2017，14，3： | 3 |
| 2 | Heterologous expression,secretion and characterization of the Geobacillus thermoleovorans US105 type Ⅰ pullulanase显示文摘 | Zouari Ayadi D Ben Ali M Jemli S Ben Mabrouk S Mezghani M Ben Messaoud E Bejar S | | 0，，03： | 1 |
| 3 | Heterologous expres- sion,secretion and characterization of the Geobaeillus thermoleo- vorans US105 type I pullulanase显示文摘 | Zouari Ayadi D Ben Ali M Jemli S | 2008 | Applied microbiology and biotechnology2008，78，： | 1 |
| 4 | Firm performance measures: Temporal roadblocks to innovation? 显示文摘 | Ayadi O F Dufrene U B Obi C P | 1996 | Managerial Finance1996，22，8： | 1 |
| 5 | Gliosarcoma with osteosarcomatous features:a short illustrated review显示文摘 | Charfi S Ayadi L Khabir A | 2009 | Acta Neurochir (Wien)2009，151，7： | 1 |
| 6 | Adipose-derived stem cells improve grafted burn wound healing by promoting wound bed blood flow显示文摘Background:Researchers have explored the use of adipose-derived stem cells(ASCs)as a cellbased therapy to cover wounds in burn patients;however,underlying mechanistic aspects are not completely understood.We hypothesized that ASCs would improve post-burn wound healing after eschar excision and grafting by increasing wound blood flow via induction of angiogenesis-related pathways.Methods:To test the hypothesis,we used an ovine burn model.A 5 cm^(2) full thickness burn wound was induced on each side of the dorsum.After 24 hours,the burned skin was excised and a 2 cm^(2) patch of autologous donor skin was grafted.The wound sites were randomly allocated to either topical application of 7 million allogeneic ASCs or placebo treatment(phosphate-buffered saline[PBS]).Effects of ASCs culture media was also compared to those of PBS.Wound healing was assessed at one and two weeks following the application of ASCs.Allogeneic ASCs were isolated,cultured and characterized from non-injured healthy sheep.The identity of the ASCs was confirmed by flow cytometry analysis,differentiation into multiple lineages and gene expression via real-time polymerase chain reaction.Wound blood flow,epithelialization,graft size and take and the expression of vascular endothelial growth factor(VEGF)were determined via enzyme-linked immunosorbent assay and Western blot.Results:Treatment with ASCs accelerated the patch graft growth compared to the control(p<0.05).Topical application of ASCs significantly increased wound blood flow(p<0.05).Expression of VEGF was significantly higher in the wounds treated with ASCs compared to control(p<0.05).Conclusions:ASCs accelerated grafted skin growth possibly by increasing the blood flow via angiogenesis induced by a VEGF-dependent pathway. | Osamu Fujiwara Anesh Prasai Dannelys Perez-Bello Amina El Ayadi Irene Y.Petrov Rinat O.Esenaliev Yuriy Petrov David N.Herndon Celeste C.Finnerty Donald S.Prough Perenlei Enkhbaatar | 2020 | Burns & Trauma2020，8，1： | 1 |
| 7 | Micronodular thymoma with lymphoid stroma: report of two cases and particular association with thymic lymphoid hyperplasia in one case显示文摘 | El M F Braham E Ayadi A | 2006 | Pathology2006，38，6： | 1 |
| 8 | Pigmented lipofibromato-sis in unusual location : case report and review of the literature显示文摘 | Ayadi L Charfi S Ben Hamed Y | 2008 | Virchows Arch2008，452，4： | 1 |
| 9 | DNA repair gene polymorphisms at XRCC1 ( Arg194Trp, Arg280His, and Arg399Gln) in a healthy Tunisian population: interethnic variation and functional prediction 显示文摘 | Salah GB Ayadi I Fendri-Kriaa N | 2012 | Genet Test Mol Biomarkers2012，16，10： | 1 |
| 10 | Aberrant methylation of p16,DLEC1,BLU and E-cadherin gene promoters in nasopharyngeal carcinoma biopsies from Tunisian patients显示文摘 | Ayadi W Karray-Hakim H Khabir A | 2008 | Anticancer Res2008，28，4： | 1 |
| 11 | A full genome screening in a large Tunisian family affected with thyroid autoimmune disorders显示文摘 | Maalej A Makni H Ayadi F | 2001 | Genes Immun2001，2，： | 1 |
| 12 | Preparation and characterization of n-type conductive (A1, Co) co-doped ZnO thin films deposited by sputtering from aerogel nanopowders 显示文摘 | Mir L E Ayadi Z B Saadoun M | 2007 | Appl Surf Sci2007，254，： | 1 |
| 13 | Lack of association between endothelial nitric oxide synthase gene G894T polymorphism hypertension in the Tunisian population显示文摘 | Sediri Y Kallel A Ayadi I | 2010 | Prev Med2010，，1： | 1 |
| 14 | Heterologous expression, secretion and characterization of the Geobacillus thermoleovorans US105 type I pullulanase显示文摘 | Dorra Zouari Ayadi Mamdouh Ben Ali Sonia Jemli Sameh Ben Mabrouk Monia Mezghani Ezzedine Ben Messaoud Samir Bejar | 2008 | Applied Microbiology and Biotechnology2008，，3： | 1 |
| 15 | Haplotypes for 13 Y-chromosomal STR loci in South Tunisian population (Sfax region) 显示文摘 | Ayadi I Ammar-Keskes L Rebai A | 2006 | Forensic Sci Int2006，164，23： | 1 |
| 16 | Numerical simulation of the one-dimensional incommensurate charge density wave dynamics显示文摘 | Qjani M Arbaoui A Ayadi A | 1998 | Synthetic Metals1998，96，2： | 1 |
| 17 | Root cell characteristics of two wheat species differing in their sensitivity to NaCl in response to salt stress显示文摘 | Jbir N Ammar S Ayadi A 2003 | 2003 | Journal of Trace and Microprobe Techniques2003，21，4： | 1 |
| 18 | Aberrant methylation of p16,DLEC1,BLU and E-cadherin gene promo-ters in nasopharyngeal carcinoma biopsies from Tunisian patients 显示文摘 | AYADI W KARRAY HAKIM H KHABIR A | 2008 | Anticancer Res2008，28，4： | 1 |
| 19 | Survey on speech emotion recognition:Features,classification schemes,databases显示文摘 | Ayadi ME Kamel MS Karray F | | 0，，03： | 1 |
| 20 | Functions and Clinical Implications of Autocrine VEGF Signaling in Colorectal Cancer显示文摘 | Annette K. Larsen Aimery Gramont Virginie Poindessous Ana?s Bouygues Mériam Ayadi Paul Mésange | 2013 | Current Colorectal Cancer Reports2013，，3： | 1 |
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