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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Spatial epidemiology of diabetes: Methods and insights显示文摘Diabetes mellitus(DM)is a growing epidemic with global proportions.It is estimated that in 2019,463 million adults aged 20-79 years were living with DM.The latest evidence shows that DM continues to be a significant global health challenge and is likely to continue to grow substantially in the next decades,which would have major implications for healthcare expenditures,particularly in developing countries.Hence,new conceptual and methodological approaches to tackle the epidemic are long overdue.Spatial epidemiology has been a successful approach to control infectious disease epidemics like malaria and human immunodeficiency virus.The implementation of this approach has been expanded to include the study of non-communicable diseases like cancer and cardiovascular diseases.In this review,we discussed the implementation and use of spatial epidemiology and Geographic Information Systems to the study of DM.We reviewed several spatial methods used to understand the spatial structure of the disease and identify the potential geographical drivers of the spatial distribution of DM.Finally,we discussed the use of spatial epidemiology on the design and implementation of geographically targeted prevention and treatment interventions against DM. | Diego F Cuadros Jingjing Li Godfrey Musuka Susanne F Awad | 2021 | World Journal of Diabetes2021，12，7： | 10 |
| 3 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 4 | Clonal analysis of the differentiation potential of human adipose-derived adult stem cells 显示文摘 | Guilak F Lott KE Awad HA | 2006 | J Cell Physiol2006，206，1： | 1 |
| 5 | Exploring the value of online product reviews in forecasting sales: The case of motion pictures显示文摘 | Dellarocas C Zhang X M Awad N F | 2007 | Journal of interactive marketing2007，21，4： | 1 |
| 6 | Effect of sampling jitter on some sine wave measurements 显示文摘 | Wagdy M F Awad S S | 1990 | IEEE Transactions on Instrumentation and Measurement1990，39，1： | 1 |
| 7 | The use of a cell saver during repair of ruptured abdom inalaortic aneurysms increases early survival显示文摘 | Serracino-Inglott F Awad S Barclay A | 2005 | Ann R Coll Surg Engl2005，87，6： | 1 |
| 8 | Exploring the value of online product reviews' in forecasting sales: The case of motion pictures 显示文摘 | Dellarocas C Zhang X M Awad N F | 2007 | Journal of Interactive Marketing2007，21，4： | 1 |
| 9 | Exploring the Value of On- line Product Reviews in Forecasting Sales : The Case of Motion Pic- tures 显示文摘 | Dellarocas C Zhang X Q Awad N F | 2007 | Journal of Interactive Marketing2007，21，4： | 1 |
| 10 | Factors affecting recovery and discharge following ambulatory surgery 显示文摘 | Awad IT Chung F | 2006 | Can J Anaesth2006，53，9： | 1 |
| 11 | Exploring the value of on- line product reviews in forecasting sales: The case of motion pictures 显示文摘 | Dellarocas C Zhang X M Awad N F | 2007 | Journal of Interactive marketing2007，21，4： | 1 |
| 12 | In vitro effects of deoxynivalenol on small intestinal D-glucose uptake and absorp- tion of deoxynivalenol across the isolated jejunal epithelium of lay- ing hens显示文摘 | Awad W A Aschenbach J R Setyabud: F | 2007 | Poultry Science2007，86，1： | 1 |
| 13 | Exploring the value of online product leviews in forecasting sales : the case of mo- tion pictures显示文摘 | Dellarocas C Zhang Xiaoquan Awad N F | 2007 | Journal of Interactive Marketing2007，21，4： | 1 |
| 14 | The use of a cell saver during repair of ruptured abdominal aortic aneurysms increases early survival显示文摘 | Serraclno - Inglott F Awad S Barelay A | 2005 | Ann R Coil SuIT Engl2005，87，： | 1 |
| 15 | In vitro effects of deoxynivalenol on small intestinal D-glucose uptake and absorp- tion of deoxynivalenol across the isolated jejunal epithelium of lay- ing hens显示文摘 | Awad W A Aschenbach J R Setyabudi F | 2007 | Poultry Science2007，86，1： | 1 |
| 16 | Clonal analysis of multipotent differentiation of human adipose-derived adult stem sells显示文摘 | Guilak F Lott KE Awad HA | 2006 | J Cell Physiol2006，206，1： | 1 |
| 17 | The use of a cell saver during repair of ruptured abdominal aortic aneurysms increases early survival显示文摘 | Serracino-Inglott F Awad S Barclay A | 2005 | Ann R Coll Surg Engl2005，87，6： | 1 |
| 18 | The combined effect of some soil conditioners and saline irrigation water显示文摘 | AWAD F ABD-EL R M ASSARD F F | 1986 | Agrochimica1986，30，： | 1 |
| 19 | Deprotonation of benzoxazole and oxazole using lithium magnesates显示文摘 | BAYH O AWAD H MONGIN F | | 0，，13： | 1 |
| 20 | Factors affecting recovery and discharge following ambulatory surgery显示文摘 | Awad IT Chung F | 2006 | Can J Anaesth2006，53，9： | 1 |
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