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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Polymers with pendent functional groupsV: thermooxidative and thermal behavior of chloro-methylated polysulfones显示文摘 | Avram E Brebu M A Warshawsky A | 2000 | Polym Deg& Sta2000，69，： | 1 |
| 3 | Predictors of survzval in continuous ambulatory preritoneal dialysis patients:the importance of preALbumin and other nutritional and metabolic markers显示文摘 | Avram MM Goldwasserp P Erroa M | 1994 | Am J Kidney Dialysis1994，23，2： | 1 |
| 4 | A systematic review of early versus delayed wound closure in patients with open fractures requi- ting flap coverage 显示文摘 | Wood T Sameem M Avram R | 2012 | J Trauma Acute Care Surg2012，72，4： | 1 |
| 5 | The Pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment 显示文摘 | De Wolf AM Rangen R J Avram M J | 2001 | Anesth Analg2001，93，5： | 1 |
| 6 | Hemodynamic contsequences of continuous arteriovenous hemofiltration显示文摘 | Lauer A Alvis R Avram M | 1998 | Am J Kidney Dis1998，12，： | 1 |
| 7 | Signal dependence on magnetic nanoparticles position over a planar Hall effect biosensor显示文摘 | Volmer M Avram M | 2013 | Microelectronic Engineering2013，108，： | 1 |
| 8 | The effectiveness of electromyographicbiofeedback as part of a meniscal repair rehabilitationprogramme 显示文摘 | ORAVITAN M AVRAM C | 2013 | J Sports Sci Med2013，12，3： | 1 |
| 9 | Accurately communicating the extent of a hair transplant procedure: a proposal of a follicular-based classifica-tion scheme 显示文摘 | Avram M R | 1997 | Dermatol Surg1997，23，9： | 1 |
| 10 | Using front-end kinetics to optimize target-controlled drug infusions 显示文摘 | AVRAM M J KREJCIE T C | 2003 | Anesthesiology2003，99，5： | 1 |
| 11 | Predictors of surivival in continuous ambulatory peritoneal dialysis patients: the importance of prealbumin and other nutritional and metabolic markers 显示文摘 | Avram MM Goldwasser P Erroa M | 1994 | Am J Kidney Dis1994，23，1： | 1 |
| 12 | Recent experience with high-dose intravenous iron administration显示文摘 | Blaustein D A Schwenk M H Chattopadhyay J Avram M M | 2006 | Kidney Int2006，70，： | 1 |
| 13 | Quantification of scattering from fiber surface irregularities显示文摘 | Avram E Mahmood W e zer M | 2002 | Journal of Lightwave Technology2002，20，4： | 1 |
| 14 | Hemodynamic consequences of continuous arteriovenous hemofiltration显示文摘 | Lauer A Alvis R Avram M | 1988 | Am J Kidney Dis1988，12，： | 1 |
| 15 | Follicular unit transplantation for male and female pat tern hair loss and restoring eyebrows显示文摘 | Avram M | 2005 | Ophthalmol Clin North Am2005，18，： | 1 |
| 16 | Surgical treatment of pancreatic pseudocysts 显示文摘 | Avram M | 2002 | Surg Clin North Am2002，81，2： | 1 |
| 17 | A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species 显示文摘 | VASKEN APOSHIAN H ZAKHARYAN R A AVRAM M D | 2004 | Toxicol Appl Pharmacol2004，198，3： | 1 |
| 18 | Crystal Field Analysis of Energy Level Structure of Li Al O2∶V3+and Li Ga O2∶V3+显示文摘 | Brik M G Avram N M Avram C N | 2006 | Spectrochimica Acta2006，，63： | 1 |
| 19 | Design of optimum plate-fin natural convective heat sinks 显示文摘 | Avram B C Lyengar M Kraus A D | 2007 | ASME J Electron Packg2007，，125： | 1 |
| 20 | Russian and American put options under exponential phase type L6vy models显示文摘 | Asmussen S Avram F Pistorius M R | 2004 | Stochastic Processes and their Applications2004，109，： | 1 |
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