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| 1 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 2 | Evaluation of hepatoprotective effect of Amalkadi Chrita against carbon tetrachloride- induced hepatic damage in rats显示文摘 | Girish S A Sudhir G W Avinash K D | 2004 | Journal of Ethnopharmacology2004，90，： | 1 |
| 3 | Wireless sensors powered by microbial fuel cells 显示文摘 | AVINASH S HALUK B ZBIGNIEW L | 2005 | Environmental Science & Technology2005，39，： | 1 |
| 4 | Using human perceptual categories for content-based retrieval from a medical image database显示文摘 | Chi R S Christina P Avinash C K | 2002 | Computer Vision and Image Understanding2002，88，3： | 1 |
| 5 | Vision for mobile robot navigation:a survey显示文摘 | Guilherme de S Avinash K | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，2： | 1 |
| 6 | Synthe- sis and gene transfection efficaeies of PEI-cholesterol- based lipopolymers显示文摘 | Avinash B Paturu K Bhattacharya S | 2008 | Bioconjugate Chem2008，19，8： | 1 |
| 7 | Characterization of a New Bacillus cereus ATUAVP1846 Strain Producing Penicillin V Acylase, and Optimization of Fermentation Parameters显示文摘 | AVINASH V S ATUL K NAIK N | 2011 | Ann Microbiol2011，10，： | 1 |
| 8 | Enhanced biodegradation and detoxification of disperse azo dye Rubine GFL and textile industry effluent by defined fungal-bacterial consortium显示文摘 | Harshad S L Tatoba R W Avinash A K | 2012 | International Biodeterioration & Biodegradation2012，72，： | 1 |
| 9 | An integrated approach for machine tool selection using fuzzy analytical hierarchy process and grey relational analysis显示文摘 | Avinash Samvedi Vipul Jain Felix T S Chan | 2012 | Int J of Production Research2012，50，12： | 1 |
| 10 | Covalent modification and exfoliation of graphene oxide using ferrocene显示文摘 | AVINASH M B SUBRAHMANYAM K S SUNDARAYYA Y | 2010 | Nanoscale2010，2，9： | 1 |
| 11 | Transient analysis following tripping of a primary circulating pump for 500-MWe PHWR power plant 显示文摘 | Gaikwad Avinash J Rajash Kumar Vhora S F | 2003 | Nuclear Science2003，50，4： | 1 |
| 12 | A wavelet multi - resolution - based analysis ior location of the point of strike of a light- uing owrwJltagc on a transmission line 显示文摘 | Dipankar C Kislmn N K Avinash K S | 2004 | IEEE Trans on Power lhliwry2004，19，4： | 1 |
| 13 | Basin Geomorphology and Drainage Morphometry Parameters Used as Indicators for Groundwater Prospect: Insight from Geographical Information System(GIS) Technique显示文摘Influence of structural and lithological controls of various drainage patterns and their stream orientations(for 2nd, 3rd and 4th order steams) were identified to evaluate the direction and controlling factors of drainage network. To investigate the prospect of groundwater, hydrogeomorphological features of river basin viz. Mulki-Pavanje were identified and mapped. To evaluate the characteristics of the basin, different morphometric parameters(linear, areal and relief) were computed in sub-basin wise(SB-I to-VII). The linear parameters suggest drainage network is controlled by geomorphology. The form factor(Ff), elongation ratio(Re) and circularity ratio(Rc) suggest that the basin is in an elongated shape. The drainage density(Dd) indicates resistant/permeable strata under medium-dense vegetation with moderate relief. The areal parameters of the sub-basins(except SBI and Ⅲ) indicates moderate ground-slopes associated with moderately permeable rocks, which promote moderate run-off and infiltration. Drainage texture(T) of the whole basin indicates coarse texture while the SB-I, and Ⅲ showing an intermediate texture. The relief parameters namely ruggedness number(Rn) infers low basin relief and poor drainage density. To identify the most deficit/surplus zones of groundwater suitable weightages were assigned to the hydrogeomorphological units and morphometric parameters. The study reveal that the basin manifest that SB-Ⅲ shall be most deficit zone of groundwater, whereas SB-VII, VI and V are found to show increase in groundwater potentiality. Groundwater prospect area in this basin is estimated to be 7% area under poor, 44% area under moderate and 49% area under good to excellent. This paper demonstrated the potential application of geographical information system(GIS) techniques to evaluate the groundwater prospect in absence of traditional groundwater monitoring data. | Kumar Avinash B Deepika K S Jayappa | 2014 | Journal of Earth Science2014，25，6： | 1 |
| 14 | Characterization of a new Bacillus cereus ATUAVP1846 strain producing Penicillin V acylase,and optimization of fermentation parameters 显示文摘 | Avinash V S Atul K Naik N | 2011 | Ann Microhiol2011，10，： | 1 |
| 15 | Vision for mobile robot navigation:A survey显示文摘 | Guilherme N De S Avinash C | 2002 | IEEE Transactions on PaRem Analysis and Machine Intelligence2002，24，2： | 1 |
| 16 | State feedback control of multilevel inverters for D-STATCOM applications 显示文摘 | Anshuman S Arindam G Avinash J | 2007 | IEEE Transaction on PD2007，22，4： | 1 |
| 17 | Terpolymers of acrylamide,acrylic acid and acrylonitrile:further characterization and biodegradation studies显示文摘 | BRAGADISH D ISMAIL A M AVINASH K S | 2000 | Polymer international2000，49，： | 1 |
| 18 | Effect of water withdrawal on for- mation of free radical, proline accumulation and activities of anti- oxidant enzymes in ZAT12-transformed transgenic tomato plants 显示文摘 | Avinash C R Major S Kavita S | 2012 | Plant Physiology and Biochemistry2012，61，： | 1 |
| 19 | Gemini Imidazolium Surfactants: Synthesis and Their Biophysiochemical Study 显示文摘 | RAMAN K SUKHPRIT S AVINASH B | 2012 | Langmuir2012，28，11： | 1 |
| 20 | Performance evaluation of a biodiesel(rice bran oil methyl ester) fuelled transportation diesel engine显示文摘 | Shailendra S Avinash K A | 2005 | SAE Technical Papers2005，1730，： | 1 |
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