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| 1 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 2 | The electrohydrodynamic origin of turbulence in elec- trostatic precipitators 显示文摘 | ATTEN P MCCLUSKEY F M J LAHJOMR A C I | 1987 | IEEE Transactions on Indus- try Applications1987，23，4： | 1 |
| 3 | Resveratrol regulates cellular PKC α and δto inhibit growth and induce apoptosis in gastric cancer cells 显示文摘 | Atten M J Godoy - Romero E Attar BM | 2005 | Investigational New Drugs2005，23，： | 1 |
| 4 | Sharpen&Bend:recovering curved sharp edges in triangle meshes produced by feature-insensitive sampling显示文摘 | Attene M Falcidieno B Rossignac J | 2005 | IEEE Transactions on Visualization and Computer Graphics2005，11，2： | 1 |
| 5 | Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase C-mediated mechanism显示文摘 | ATTEN M J ATTAR B M MILSON T | 2001 | Biochem Pharm2001，62，10： | 1 |
| 6 | Polygon mesh repairing: An application perspective 显示文摘 | Attene M Campen M Kobbelt L | 2013 | ACM Computing Surveys (CSUR)2013，45，2： | 1 |
| 7 | Automatic Surface Reconstruction from Point Sets in Space显示文摘 | Attene M Spagnuolo M | 2000 | Computer Graphics Forum2000，19，3： | 1 |
| 8 | Heat tranfer enhancement by electroconvection resulting from an injected space charge between parallel plates 显示文摘 | McCluskey F M J Atten P | 1991 | lnt J Heat Mass Transfer1991，34，9： | 1 |
| 9 | Serum amylase and lipase elevation is associated with intracranial events 显示文摘 | Liu KL Atten M J Lichtor T | 2001 | Am Surg2001，67，3： | 1 |
| 10 | Characterization of 3D shape parts for semantic annotation 显示文摘 | Attene M Robbiano F Spagnuolo M | 2009 | Computer-Aided De- sign2009，41，10： | 1 |
| 11 | Drift velocity of fine particles estimated from fractional efficiency measurements in a laboratory-scaled electrostatic precipitator显示文摘 | DUMITRAN L M ATTEN P BLANCHARD D | 2002 | IEEE Transactions on Industry Applications2002，38，3： | 1 |
| 12 | Semantic annotation of 3D surface meshes based on feature characterization显示文摘 | ATTENE M ROBBIANO F SPAGNUOLO M | 2007 | Lecture Notes in Computer Science:Semantic Multimedia2007，48，17： | 1 |
| 13 | Gastric Iipoma with Severe Hemorrhage显示文摘 | Myint M Atten MJ Attar BM | 1996 | Am J Gastroenterol1996，91，4： | 1 |
| 14 | Characterization of 3D shape parts for semantic annotation显示文摘 | ATTENE M ROBBIANO F SPAGNUOLO M | 2009 | Computer-Aided Design2009，41，10： | 1 |
| 15 | Construction and Constitution in Mathematics 显示文摘 | Van Atten M | 2010 | The New Yearbook for Phenomenology and2010，2010，10： | 1 |
| 16 | The survival of stage III gastric cancer patients is affected by the number of lymph nodes removed 显示文摘 | Liu KJ Loewen M Atten MJ | 2003 | Surgery2003，134，4： | 1 |
| 17 | Hierarchical mesh segmentation based on fitting primitives显示文摘 | Attene M Falcidieno B Spagnuolo M | 2006 | The Visual Computer2006，22，3： | 1 |
| 18 | Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells显示文摘 | Atten M I Godoy Romero F Attar B M | 2005 | Invest New Pmg2005，23，2： | 1 |
| 19 | Gastric lipoma with severe hemorrhage显示文摘 | Myint M Atten MJ Attar BM | 1996 | Am J Gastroenterol1996，91，4： | 1 |
| 20 | Estimate of effective migration velocity of fine particles from fractional efficiency measurements in an electrostatic precipitator显示文摘 | Blanchard D Atten P | 2000 | ConfRec IAS Annu Meet2000，1，： | 1 |
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