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| 1 | Antimicrobial resistance and underlying mechanisms in Staphylococcus aureus isolates显示文摘Objective: To investigate the antimicrobial susceptibility of 97 clinical Staphylococcus aureus(S. aureus) strains against 14 antimicrobials and corresponding resistance mechanisms.Methods: The antimicrobial susceptibility of the isolates was determined using a disk diffusion method and antimicrobial resistance genes were screened by polymerase chain reaction. Mutations responsible for ciprofloxacin and rifampicin resistance were investigated by polymerase chain reaction and DNA sequencing.Results: All isolates were found to be susceptible to vancomycin. Various rates of resistance to penicillin(83.5%), ampicillin(77.3%), erythromycin(63.9%), tetracycline(16.5%), amoxicillin/clavulanic acid(16.5%), ciprofloxacin(15.5%), trimethoprim/sulfamethoxazole(15.5%), oxacillin(13.4%), fusidic acid(12.4%), rifampin(6.2%), clindamycin(6.2%), gentamicin(6.2%) and mupirocin(5.2%) were determined. In addition,different combinations of resistance genes were identified among resistant isolates.Ciprofloxacin resistant isolates had mutations in codon 84(Ser84 Leu) and 106(Gly106 Asp) in the gyr A gene. Mutations in grl A were mostly related to Ser80 Phe substitution. Leu466 Ser mutation in the rpo B gene was detected in all rifampin resistant isolates. All methicillin resistant S. aureus isolates were SCCmec type V.Conclusions: In conclusion, it was determined that the isolates were resistant to different classes of antimicrobials at varying rates and resistance was mediated by different genetic mechanisms. Therefore, continuous monitoring of resistance in S. aureus strains is necessary to control their resistance for clinically important antimicrobials. | Ebru Sebnem Yilmaz Ozkan Aslantas | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 2 |
| 2 | Effect of plant growth promoting rhizobacteria on young apple tree growth and fruit yield under orchard conditions显示文摘 | ASLANTAS R CAKMAKCI R SAHIN F | 2007 | Scientia Horticulturae2007，111，： | 1 |
| 3 | An Optimal Robust Digital Image Watermarking Based on SVD Using Differential Evolution Algorithm显示文摘 | Aslantas V | 2009 | Optics Communications2009，282，5： | 1 |
| 4 | Numerical simulation of orthogonal machining process using multilayer and single-layer coated tools显示文摘 | Irfan Ucun Kubilay Aslantas | 2011 | Int J Adv Manuf Technol2011，，54： | 1 |
| 5 | Finite element analysis of stress distribution bituminous pavement and failure mechanism 显示文摘 | AKUBLUT H ASLANTAS K | 2005 | Materials and Design2005，26，4： | 1 |
| 6 | Depth from Automatic Defocusing显示文摘 | Aslantas V Pham D T | | 0，，： | 1 |
| 7 | Effect of crack position on stress intensity factor in particle-reinforced metal-matrix composites 显示文摘 | ERGUN E ASLANTAS K | 2008 | Mechanics Research Communications2008，35，4： | 1 |
| 8 | A Depth Estimation Algorithm with A Single Image显示文摘 | Aslantas V | | 0，，： | 1 |
| 9 | An optimal robust digital image watermarking based on SVD using differential evolution algorithm显示文摘 | Aslantas V | 2009 | Optics Communications2009，282，： | 1 |
| 10 | Effect of plant growth promoting rhizobacteria on young apple tree growth and fruit yield under orchard conditions显示文摘 | ASLANTAS R AKMAKCI R SAHIN F | 2007 | Sci- entia horticulturae2007，111，4： | 1 |
| 11 | Debonding between Coating and Substrate due to Rolling Sliding Contact显示文摘 | Aslantas K Tasgetiren S | 2002 | Materials and Design2002，23，： | 1 |
| 12 | Effect of EDTA, sodium hypochlorite, and chlorhexidine gluconate with or without surface modifiers on den- tin microhardness显示文摘 | Aslantas EE Buzoglu HD Altundasar E | 2014 | J Endod2014，40，6： | 1 |
| 13 | Finite element analysis ofstress distribution on bituminous pavement and failuremechanism 显示文摘 | AKBULUT H ASLANTAS K | 2005 | Materials and Design2005，26，4： | 1 |
| 14 | Tool wear mechanism in inter-rupted cutting conditions 显示文摘 | Sayit E Aslantas K cicek A | 2009 | Mater Manuf Process2009，24，4： | 1 |
| 15 | Fusion of multi-focus images using differential evolution algorithm显示文摘 | Aslantas V Kurban R | 2010 | Expert Sys- tems with Applications2010，37，12： | 1 |
| 16 | Beauveria bassiana Pathogenicity to the Cherry Slugworm,Caliroa cerasi (Hymenoptera:Tenthredinidae) Larvae显示文摘 | ASLANTAS R EKEN C HAYAT R | 2008 | World Journal of Microbiology and Biotechnology2008，24，： | 1 |
| 17 | Plasma adropin levelspredict endothelial dysfunction like flow - mediated dilatation inpatients with type 2 diabetes mellitus 显示文摘 | Topuz M Celik A Aslantas T | 2013 | J Investig Med2013，61，8： | 1 |
| 18 | Investigation of the effect of axial cutting force on circular diamond sawblade used in marble cutting process显示文摘 | ASLANTAS K (O)ZBEK O UCUN (I) B(U)Y(U)KSA(G)(I)(S) (I) S | | 0，，02： | 1 |
| 19 | Austempering retards pitting failure in ductile iron spur gears显示文摘 | Aslantas K Tas_getiren S Yalcin Y | 2004 | Enging Failure Anal2004，11，： | 1 |
| 20 | Depth from automatic defocusing 显示文摘 | Aslantas V Pharm D T | 2007 | Optics Express2007，3，15： | 1 |
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