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| 1 | Neoadjuvant treatment strategies for intrahepatic cholangiocarcinoma显示文摘Intrahepatic cholangiocarcinoma(ICC)is the second most common primary liver malignancy and is increasing in incidence.Long-term outcomes are optimized when patients undergo margin-negative resection followed by adjuvant chemotherapy.Unfortunately,a significant proportion of patients present with locally advanced,unresectable disease.Furthermore,recurrence rates are high even among patients who undergo surgical resection.The delivery of systemic and/or liver-directed therapies prior to surgery may increase the proportion of patients who are eligible for surgery and reduce recurrence rates by prioritizing early systemic therapy for this aggressive cancer.Nevertheless,the available evidence for neoadjuvant therapy in ICC is currently limited yet recent advances in liver directed therapies,chemotherapy regimens,and targeted therapies have generated increasing interest its role.In this article,we review the rationale for,current evidence for,and ongoing research efforts in the use of neoadjuvant therapy for ICC. | Clifford Akateh Aslam M Ejaz Timothy Michael Pawlik Jordan M Cloyd | 2020 | World Journal of Hepatology2020，12，10： | 8 |
| 2 | Surgery for colorectal liver metastases: The evolution of determining prognosis显示文摘Despite improvements in the multi-modality treatment of colorectal liver metastasis (CRLM), survival after resection remains varied. Determining prognosis after surgical resection has historically been predicated on preoperative clinicopathological factors such as primary tumor stage, carcinoembryonic antigen levels, number of liver metastases, presence of extrahepatic disease, as well as other factors. While scoring systems have been developed by combining certain preoperative fac- tors, these have been inconsistent in accurately deter- mining prognosis. There has been increasing interest in the use of biologic and molecular markers to predict prognosis following CRLM. The role of markers such as KRAS, BRAF, p53, human telomerase reverse transcrip- tase, thymidylate synthase, Ki-67, and hypoxia inducible factor-1α and their correlation with accurately predict- ing survival after surgical resection have been sup- ported by several studies. Furthermore, other elements such as pathological response to chemotherapy and the presence of circulating tumor cells have shown promise in accurately determining prognosis after resection for colorectal liver metastasis.We herein review past, present, and possible future markers of prognosis among colorectal cancer patients with liver metastasis undergo-ing resection with curative intent. | Gaya Spolverato Aslam Ejaz Nilo Azad Timothy M Pawlik | 2013 | World Journal of Gastrointestinal Oncology2013，5，12： | 7 |
| 3 | Patients with critical ischemia of the lowlimb are at risk of developing kidney dysfunction 显示文摘 | Morsey H Aslam M Standfield N | 2003 | Am J Surg2003，184，4： | 1 |
| 4 | Parameters of the rectoanal inhibitory reflex in patients with idiopathic fecal incontinence and chronic constipation显示文摘 | Zbar AP Aslam M Gold OM | 1998 | Dis Colon Rectum1998，41，2： | 1 |
| 5 | Three new novel point mutations localized within and downstream of high-mobility group-box region in SRY gene in three Indian females with Turner syndrome显示文摘 | Shahid M Dhillon VS Aslam M | | 0，，4： | 1 |
| 6 | MicroRNAs are novel biomarkers of colorectal cancer显示文摘 | Aslam M I Taylor K Pringle J H | | 0，，07： | 1 |
| 7 | Opposing effects of ATP and adenosine on barrier function of rat coronary microvasculature显示文摘 | Gündüz D Aslam M Krieger U | 2012 | J Mol Cell Cardiol2012，52，5： | 1 |
| 8 | Wilms'tumour:a comparison of surgical aspects in patients with or without tive chemothcrapy显示文摘 | SAFDA C A ASLAM M AWAN S H | 2006 | J Coil Physicians Surg Pak2006，16，8： | 1 |
| 9 | A highly selective ammonia gas sensor using surface-ruthenated zinc oxide显示文摘 | ASLAM M CHAUDHARY V A MULLA I S | 1999 | Sensors and Actuators A1999，75，2： | 1 |
| 10 | Effect of vegetation cover on the radar sensitivity to soil moisture显示文摘 | Ulaby F T Aslam A Dobson M C | 1982 | IEEE Transaction on Geosci Remote Sensing1982，20，4： | 1 |
| 11 | Multiple levels of Notch sig- nal regulation显示文摘 | Baron M Aslam H Flasza M | 2002 | Mol Membr Biol2002，19，1： | 1 |
| 12 | The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer显示文摘 | Thornton M Aslam MA Tweedle EM | 2013 | Int J Cancer2013，133，6： | 1 |
| 13 | Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension显示文摘 | Lee C Mitsialis SA Aslam M | 2012 | Circulation2012，126，22： | 1 |
| 14 | Piezoresistive microsensors using p-type CVD diamond films 显示文摘 | Taher I Aslam M Tamor M A | 1994 | Sens Actuat1994，45，： | 1 |
| 15 | Diffusion-weighted imaging of cerebral abscess and subdural empyema 显示文摘 | Aslam M Cherryman PG | 2000 | Am J Neuroradiol2000，21，6： | 1 |
| 16 | Systematic review and meta-analysisonmanagement of hemodialysis catheter-re- lated bacteremia 显示文摘 | Aslam S Vaida F Ritter M | 2014 | J Am SocNephrol2014，25，12： | 1 |
| 17 | Bronchioalveo1ar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia显示文摘 | Tropea KA Leder E Aslam M | 2012 | AmJ Physiol Lung Cell Mol Physiol2012，302，9： | 1 |
| 18 | Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo 显示文摘 | Aslam R Speck ER Kim M | 2006 | Blood2006，107，2： | 1 |
| 19 | Differential effect of amino acid on nitrate uptake and reduction systems in barley roots显示文摘 | Aslam M Travis R L Rains D W | 2001 | Plant Science2001，160，： | 1 |
| 20 | An experimental investigation of CNG as an alternative fuel for a retrofitted gasoline vehicle显示文摘 | ASLAM M U | 2006 | Fuel2006，86，56： | 1 |
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