|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation显示文摘AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR. CONCLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation. | Ashley M Lakner Cathy C Moore Alyssa A Gulledge Laura W Schrum | 2010 | World Journal of Gastroenterology2010，16，40： | 23 |
| 2 | microRNAs: Fad or future of liver disease显示文摘microRNAs (miRs) are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition. miRs influence at least one third of all human transcripts and are known regulators of various important cellular growth and differentiation factors. miRs have recently emerged as key regulatory molecules in chronic liver disease. This review details recent contributions to the field of miRs that influence liver development and the broad spectrum of disease, from non-alcoholic fatty liver disease to fibrosis/cirrhosis, with particular emphasis on hepatic stellate cells and potential use of miRs as therapeutic tools. | Ashley M Lakner Herbert L Bonkovsky Laura W Schrum | 2011 | World Journal of Gastroenterology2011，17，20： | 13 |
| 3 | Liver transplantation and the management of progressive familial intrahepatic cholestasis in children显示文摘Progressive familial intrahepatic cholestasis(PFIC) is a constellation of inherited disorders that result in the impairment of bile flow through the liver that predominantly affects children. The accumulation of bile results in progressive liver damage, and if left untreated leads to end stage liver disease and death. Patients often present with worsening jaundice and pruritis within the first few years of life. Many of these patients will progress to end stage liver disease and require liver transplantation. The role and timing of liver transplantation still remains debated especially in the management of PFIC1. In those patients who are appropriately selected, liver transplantation offers an excellent survival benefit. Appropriate timing and selection of patients for liver transplantation will be discussed, and the short and long term management of patients post liver transplantation will also be described. | Ashley Mehl Humberto Bohorquez Maria-Stella Serrano Gretchen Galliano Trevor W Reichman | 2016 | World Journal of Transplantation2016，6，2： | 6 |
| 4 | 子痫前期:病理生理学和临床意义显示文摘子痫前期是一种常见疾病,尤其影响首次妊娠。其临床表现多样,但通常表现为高血压和蛋白尿。这些全身症状是由于在合体滋养细胞的压力作用下,胎盘释放了可溶性因子。子痫前期主要有早发型和迟发型2种亚型,其他几种亚型目前尚未确定。早发型子痫前期是由于胎盘缺陷而出现,而迟发型子痫前期可能是由于胎盘的正常衰老,以及母体对心血管和代谢疾病的遗传易感性交互产生。子痫前期因胎盘和母体因素产生的原因因人而异。最近的研究主要集中在早孕期的胎盘-子宫相互作用。本文旨在对关于子痫前期的预测、预防和治疗方法的最新文献进行归纳综述。 | Graham J Burton Christopher W Redman James M Roberts Ashley Moffett 秦萌(译) 金滢 潘凌亚(校 | 2019 | 英国医学杂志中文版2019，22，11： | 6 |
| 5 | Alcoholic hepatitis: The pivotal role of Kupffer cells显示文摘Kupffer cells play a central role in the pathogenesis of alcoholic hepatitis(AH). It is believed that alcohol increases the gut permeability that results in raised levels of serum endotoxins containing lipopolysaccharides(LPS). LPS binds to LPS-binding proteins and presents it to a membrane glycoprotein called CD14, which then activates Kupffer cells via a receptor called tolllike receptor 4. This endotoxin mediated activation of Kupffer cells plays an important role in the inflammatory process resulting in alcoholic hepatitis. There is no effective treatment for AH, although notable progress has been made over the last decade in understanding the underlying mechanism of alcoholic hepatitis. We specifically review the current research on the role of Kupffer cells in the pathogenesis of AH and the treatment strategies. We suggest that the imbalance between the pro-inflammatory and the anti-inflammatory process as well as the increased production of reactive oxygen species eventually lead to hepatocyte injury, the final event of alcoholic hepatitis. | Duminda B Suraweera Ashley N Weeratunga Robert W Hu Stephen J Pandol Richard Hu | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 3 |
| 6 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 7 | Sediment origins, deposition and build-up in combined sewer systems显示文摘 | ASHLEY R M CRABTREE R W | 1992 | Water Science & Technology1992，25，8： | 1 |
| 8 | IL-17-producing human peripheral regulatory T cells retain suppressive function显示文摘 | Beriou G Costantino C M Ashley C W | 2009 | Blood2009，113，18： | 1 |
| 9 | A practical scientific app roach to riparian vegetation rehabilitation in Australia显示文摘 | Ashley A W Wayne D E | 2003 | Journal of Environmental Management2003，68，4： | 1 |
| 10 | Current issues in gastrointestinal stromal tumors: incidence, molecular biology, and contemporary treatment of localized and advanced disease显示文摘 | Chandrajit P Raut Jeffrey A Morgan Stanley W Ashley | 2007 | Current Opinion in Gastroenterology2007，，2： | 1 |
| 11 | Synthesis and biological evaluation of c-aminophosphonates as potent, subtype-selectivesphingosine 1-phosphate receptor qagonists and antagonists 显示文摘 | Frank W Foss Jr Ashley H Snyder Michael D Davis | 2007 | Bioorg Med Chem2007，15，2： | 1 |
| 12 | Translation and protein synthesis:macrolides显示文摘 | Katz L Ashley G W | 2005 | Chem Rev2005，105，2： | 1 |
| 13 | Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation显示文摘 | AJ Stanley D Ashley HR Dalton C Mowat DR Gaya E Thompson U Warshow M Groome A Cahill G Benson O Blatchford W Murray | 2009 | The Lancet2009，，9657： | 1 |
| 14 | A review of the opti- cal properties of biological tissues 显示文摘 | WAIF C SCOTT A P ASHLEY J W | 1990 | IEEE J Quant Elee1990，26，12： | 1 |
| 15 | Current management of necrotizing pancreatitis显示文摘 | Clancy T E Ashley S W | 2002 | Adv Surg2002，36，5： | 1 |
| 16 | Ghrelin promotesintestinal epithelial cell proliferation through PI3K/Aktpathway and EGFR transactivation both converging to ERK1/2phosphorylation显示文摘 | WASEEM T DUXBURY M ASHLEY S W | 2014 | Peptides2014，52，： | 1 |
| 17 | Predicting the need for calci- um and calcitriol supplementation after total thyroidectomy: Re- suits of a prospective, randomized study 显示文摘 | Ashley K Tina W Sarah M | 2012 | Surgery2012，152，6： | 1 |
| 18 | Degenerate four-wave mixing in colloidal gold as a function of particle size显示文摘 | Haus J W Ashley P R | 1990 | J Opt Soc Am1990，，7： | 1 |
| 19 | Stock Prices and Changes in Earnings and Dividends: Some Empirical Results 显示文摘 | Ashley J W | 1962 | The Journal of Political Economy1962，70，1： | 1 |
| 20 | QTLs conditioning early growth in a soybean population segregating for growth habit 显示文摘 | Mian W A R Ashley D A Vencill W K | 1998 | Theor Appl Genet1998，97，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员