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| 1 | Polymethylmethacrylate bone cements and additives: A review of the literature显示文摘Polymethylmethacrylate(PMMA) bone cement technology has progressed from industrial Plexiglass administration in the 1950 s to the recent advent of nanoparticle additives. Additives have been trialed to address problems with modern bone cements such as the loosening of prosthesis, high post-operative infection rates, and inflammatory reduction in interface integrity. This review aims to assess current additives used in PMMA bone cements and offer an insight regarding future directions for this biomaterial. Low index(< 15%) vitamin E and low index(< 5 g) antibiotic impregnated additives significantly address infection and inflammatory problems, with only modest reductions in mechanical strength. Chitosan(15% w/w PMMA) and silver(1% w/w PMMA) nanoparticles have strong antibacterial activity with no significant reduction in mechanical strength. Future work on PMMA bone cements should focus on trialing combinations of these additives as this may enhance favourable properties. | Manit Arora Edward KS Chan Sunil Gupta Ashish D Diwan | 2013 | World Journal of Orthopedics2013，4，2： | 10 |
| 2 | Extraction and RP-HPLC determination of taxol in rat plasma, cell culture and quality control samples显示文摘A rapid,sensitive,selective and validated reverse phase high-performance liquid chromatography(RP-HPLC)method for the estimation of paclitaxel in micro-sample of rat plasma and in culture of cancer cells was performed in this study.The mobile phase consisted of an optimized mixture of methanol:water:trifluroacetic acid(80:20:0.1,v/v/v).Column elution at a flow rate of 1 mL/minute with UV detection at 225 nm at room temperature was used.The RP-HPLC method was successfully applied for the determination of paclitaxel in plasma samples and in culture of cancer cells with nano-quantity of estimation.The validation studies were performed in accordance with the International Conference on Harmonization(ICH)guidelines.The intra-and inter-day precision showed that the coefficients of variation ranged from 1.07%to 4.27%at different levels of concentrations.To the best of our knowledge,this study also reported for the first time the optimization of different solvents for effective extraction of paclitaxel wherein tert.-butyl methyl ether(TBME):diethyl ether(DEE)in 50:50 v/v composition was found most efficient with extraction efficiency ranging between 77.99%and 91.74%and between 76.14 and 93.66%in the plasma and cell culture,respectively.This proposed method was successfully applied to study the pharmacokinetics of paclitaxel and the influence of verapamil and all-trans retinoic acid(atRA)on paclitaxel pharmacokinetics in rat models.This proposed method might emerge as a valuable aid in the laboratory monitoring of paclitaxel in a variety of in vitro as well as in vivo scenarios. | Rakesh Kumar Tekade Antony D'Emanuele Abdelbary Elhissi Ashish Agrawal Anurekha Jain Basel Tawfiq Arafat Narendra Kumar Jain | 2013 | The Journal of Biomedical Research2013，27，5： | 5 |
| 3 | Adalimumab Induces and Maintains Mucosal Healing in Patients With Crohn’s Disease: Data From the EXTEND Trial显示文摘 | Paul Rutgeerts Gert Van Assche William J. Sandborn Douglas C. Wolf Karel Geboes Jean–Frédéric Colombel Walter Reinisch Ashish Kumar Andreas Lazar Anne Camez Kathleen G. Lomax Paul F. Pollack Geert D’Haens | 2012 | Gastroenterology2012，，5： | 4 |
| 4 | Reducing Hospital Morbidity and Mortality Following Esophagectomy显示文摘 | B.Zane Atkins Ashish S. Shah Kelley A. Hutcheson Jennifer H. Mangum Theodore N. Pappas David H. Harpole Thomas A. D’Amico | 2004 | The Annals of Thoracic Surgery2004，，4： | 2 |
| 5 | Coupled bending-torsional vibra- tion analysis for rotor with rub and crack显示文摘 | Tejas H P Ashish K D | 2009 | Journal of Sound and Vibration2009，326，35： | 1 |
| 6 | Petroleum residue upgrading via delayed coking:A review显示文摘 | Ashish N S Aniruddha B P Shriniwas D S | | 0，，01： | 1 |
| 7 | Novel carboxymethyl chitin nanoparticles for cancer drug delivery applications显示文摘 | Ashish D Jithin MC Sreeja V | 2010 | Carbohydr Polym2010，79，4： | 1 |
| 8 | Chemical treatment for improved performance of reverse osmosis membranes显示文摘 | Mukherjee D Ashish K William N G | 1996 | Desalination1996，104，： | 1 |
| 9 | Coupled bending-torsional vibration analysis of rotor with rub and crack 显示文摘 | TEJAS H P ASHISH K D | 2009 | Journal of Sound and Vibration2009，326，35： | 1 |
| 10 | Ranolazine stabilizes cardiac ryanodine receptors a novel mechanism for the suppres- sion of early afterdepolarization and torsades de pointes in long QTtype2显示文摘 | Ashish P Eng R Mantravadi D | 2012 | Heart Rhythm2012，9，6： | 1 |
| 11 | Nitric oxide modulate fracture healing显示文摘 | Ashish D Wang MX Jang D | 2000 | J of Bone and Min Resr2000，15，2： | 1 |
| 12 | Pharmacokinetics of bupropion and its metabolites in cigarette smokers versus nonsmokers 显示文摘 | Poe-Hirr H Ashish S Tracie D | 1997 | J Clin Pharmacol1997，37，8： | 1 |
| 13 | Adalimumab Induces and Maintains Mucosal Healing in Patients With Crohn’s Disease: Data From the EXTEND Trial显示文摘 | Paul Rutgeerts Gert Van Assche William J. Sandborn Douglas C. Wolf Karel Geboes Jean–Frédéric Colombel Walter Reinisch Ashish Kumar Andreas Lazar Anne Camez Kathleen G. Lomax Paul F. Pollack Geert D’Haens | 2012 | Gastroenterology2012，，5： | 1 |
| 14 | Christofides,simulation,estimation and control of size distribution in aerosol processes with simultaneous reaction,nucleation,condensation and coagulation显示文摘 | Ashish Kalani Panagiotis D | 2002 | Computer and Chemical Engineering2002，26，78： | 1 |
| 15 | Measurement of flexural toughness of fiber reinforced concrete using a novel technique-part2:Performance of various composites显示文摘 | Nemkumar B Ashish D | 2000 | ACI Materials Journal2000，97，1： | 1 |
| 16 | Importance of phase of aluminum nanoparticles 显示文摘 | Ashish R Lee D Kihong P M | 2004 | American Chemical Society2004，9，14： | 1 |
| 17 | Reducing Hospital Morbidity and Mortality Following Esophagectomy显示文摘 | B.Zane Atkins Ashish S. Shah Kelley A. Hutcheson Jennifer H. Mangum Theodore N. Pappas David H. Harpole Thomas A. D’Amico | 2004 | The Annals of Thoracic Surgery2004，，4： | 1 |
| 18 | Porous media based model for deep-fat vacuum frying potato chips显示文摘 | ALEXANDER W ASHISH D DIANA M | 2012 | J Food Eng2012，110，3： | 1 |
| 19 | Nitric oxide modulates fracture healing显示文摘 | Diwan AD Min X | 2000 | Bone2000，15，2： | 1 |
| 20 | Pharmacokinetics of bupropion and its metabolites in cigarette smokers versus non- smokers 显示文摘 | Poe-Hirr H Ashish S Tracie D | 1997 | J Clin Pharmacol1997，37，10： | 1 |
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