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| 1 | Gender difference in gastro-esophageal reflux diseases显示文摘The incidence of esophageal adenocarcinoma(EAC) has risen sharply in western countries over the past 4 decades. This type of cancer is considered to follow a transitional process that goes from gastro-esophageal reflux disease(GERD) to Barrett's esophagus(BE,a metaplastic condition of the distal esophagus), a precursor lesion and ultimately adenocarcinoma. This spectrum of GERD is strongly predominant in males due to an unidentified mechanism. Several epidemiologic studies have des cribed that the prevalence of GERD, BE and EAC in women is closely related to reproductive status, which suggests a possible association with the estrogen level. Recently, we revealed in an in vivo study that the inactivation of mast cells by the anti-inflammatory function of estrogen may account for the gender difference in the GERD spectrum. Other studies have described the contribution of female steroid hormones to the gender difference in these diseases. Estrogen is reported to modulate the metabolism of fat, and obesity is a main risk factor of GERDs. Moreover, estrogen could confer esophageal epithelial resistance to causative refluxate. These functions of estrogen might explain the approximately 20-year delay in the incidence of BE and the subsequent development of EAC in women compared to men, and this effect may be responsible for the male predominance. However, some observational studies demonstrated that hormone replacement therapy exerts controversial effects in GERD patients. Nevertheless, the estrogen-related endocrine milieu may prevent disease progression toward carcinogenesis in GERD patients. The development of innovative alternatives to conventional acid suppressors may become possible by clarifying the mechanisms of estrogen. | kiyotaka asanuma katsunori iijima tooru shimosegawa | 2016 | World Journal of Gastroenterology2016，22，5： | 9 |
| 2 | Cytotoxic T Lymphocytes Efficiently Recognize Human Colon Cancer Stem-Like Cells显示文摘 | Satoko Inoda Yoshihiko Hirohashi Toshihiko Torigoe Rena Morita Akari Takahashi Hiroko Asanuma Munehide Nakatsugawa Satoshi Nishizawa Yasuaki Tamura Tetsuhiro Tsuruma Takeshi Terui Toru Kondo Kunihiko Ishitani Tadashi Hasegawa Koichi Hirata Noriyuki Sato | 2011 | The American Journal of Pathology2011，，4： | 2 |
| 3 | Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cells显示文摘 | Asanuma K Tsuji N Endoh T | 2004 | J Immunol2004，172，6： | 1 |
| 4 | Synaptopodin regulates the actinbundling activity of alpha-acrinin in an isoform-specific manner显示文摘 | Asanuma K Kim K Oh J | 2005 | J Clin Invest2005，115，5： | 1 |
| 5 | Protection against influenza virus infection in mice immunized by administration of hemagglutinin-expressing DNAs with electroporation显示文摘 | Kadowaki S Chen Z Asanuma H | 2000 | Vaccine2000，18，： | 1 |
| 6 | Survivin as a predictor of cis-diamminedichloroplatinum sensitivity in gastric cancer patients显示文摘 | Nakamura M Tsuji N Asanuma K | 2004 | Cancer Sci2004，95，1： | 1 |
| 7 | Tailor-made re- ceptors by molecular imprinting 显示文摘 | Asanuma H Hishiya T Komiyama M | 2000 | Advanced Materi- als2000，14，： | 1 |
| 8 | Inflammatory pseudotumor of the bladder in neonates显示文摘 | Asanuma H Nakai H Shishido S | 2000 | Int J Urol2000，7，： | 1 |
| 9 | Effects of 22- oxa-calcitriol on podocyte injury in adrimycin-induced ne- phrosis显示文摘 | Lydia A Asanuma K Nonaka K | 2012 | Am J Nephrol2012，35，1： | 1 |
| 10 | The role of podocytes in glomerulus pethobiology显示文摘 | Asanuma K Mundel P | 2003 | Clin Exp Nephrol2003，7，4： | 1 |
| 11 | Detection of autoantibodies to survivin and Livin in sera from patients with breast cancer显示文摘 | Yagihashi A Ohmura T Asanuma K | 2005 | Clin Chim Aeta2005，362，12： | 1 |
| 12 | Expression and antigenicity of survivin, an inhibitor of apoptosis family member, in bladder cancer: implications for specific immunotherapy显示文摘 | Kitamura H Torigoe T Honma I Asanuma H Nakazawa E Shi mozawa K | 2006 | Urology2006，67，： | 1 |
| 13 | Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol3-kinase/AKT signaling pathway in breast cancer cells显示文摘 | Torigoe T Kamiguchi K | 2005 | Cancer Res2005，65，11： | 1 |
| 14 | Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling显示文摘 | Asanuma K Yanagida-Asanuma E Faul C | 2006 | Nat Cell Biol2006，8，5： | 1 |
| 15 | The role of podocytes in glomerular patho-biology显示文摘 | ASANUMA K MUNDEL P | 2003 | Clin Exp Nephrol2003，7，： | 1 |
| 16 | Detection of autoantibodies to Survivin and Livin in sera from patients with breast cancer显示文摘 | YAGIHASHI A OHMURA T ASANUMA K | 2005 | Clin Chim Aeta2005，362，12： | 1 |
| 17 | Effect of the addition of fu- marate on methane production by ruminal microorganisms in vitro 显示文摘 | ASANUMA N I WAMOTO M HINO T | 1999 | Journal of Dairy Science1999，82，： | 1 |
| 18 | Relationship between affer- ent input and motor outflow in cat motorsensory cortex显示文摘 | Asanuma H Stoney SD Tr Abzug C | 1968 | J Neu- rophysiol1968，31，5： | 1 |
| 19 | The role of podocytes in glomerular pathobiology显示文摘 | ASANUMA K MUNDEL P | 2003 | Clin Exp Nephrol2003，7，4： | 1 |
| 20 | Plasma adenosine levels and platelet activation in patients with atrial fibrillation显示文摘 | Minamino T Kitakaze M Asanuma H | 1999 | Am J Cardiol1999，83，： | 1 |
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