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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Induction of the Wnt inhibitor,Dickkopf-1,is associated with neurodegeneration related to temporal lobe epilepsy显示文摘 | BUSCETI CL BIAGIONI F ARONICA E | 2007 | Epilepsia2007，48，4： | 1 |
| 3 | Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy:focal cortical dysplasia and glioneuronal tumors显示文摘 | Aronica E Gorter JA Jansen GH | 2003 | Neuroscience2003，118，： | 1 |
| 4 | The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission显示文摘 | Blumcke I Thom M Aronica E | 2011 | Epilepsia2011，52，1： | 1 |
| 5 | Long-term epilepsy- associated tumors 显示文摘 | Thom M Blurncke I Aronica E | 2012 | Brain Pathol2012，22，3： | 1 |
| 6 | Innate and adaptive immunity during epileptogenesis and spontane- ous seizures:evidence from experimental models and human temporal lobe epilepsy 显示文摘 | Ravizza T Gagliardi B No6 F Boer K Aronica E Vezzani A | 2008 | Neurobiol Dis2008，29，1： | 1 |
| 7 | Expression pattern of miR -146a, an inflammation-associated microRNA, in experi- mental and human temporal lobe epilepsy显示文摘 | Aronica E Fluiter K Iyer A | 2010 | EurJ Neurosci2010，31，6： | 1 |
| 8 | Electrocorticography discharge patterns in patients with a cavernous hemangioma and pharmacoresistent epilepsy显示文摘 | Ferrier C H Aronica E Leijten F S | 2007 | J Neurosurg2007，107，3： | 1 |
| 9 | Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy显示文摘 | ARONICA E GORTER JA RAMKEMA M | 2004 | Epilepsia2004，45，： | 1 |
| 10 | Expression and cellular discribution of major vault protein:a putative marker for pharmacosistance in a rat model for temporal lobe epilepsy显示文摘 | Van Vliet EA Aronica E Redeker S | 2004 | Epilepsia2004，45，12： | 1 |
| 11 | Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy:focal cortical dysplasia and glioneuronal tumors显示文摘 | ARONICA E GORTER JA JANSEN GH | 2003 | Neuroscience2003，118，： | 1 |
| 12 | Glial adenosine kinase -a neuro- pathological marker of the epileptic brain显示文摘 | Aronica E Sandau US Iyer A | 2013 | Neurochem Int2013，11，4： | 1 |
| 13 | Epilepsy and brain inflammation显示文摘 | Vezzani A Aronica E Mazarati A | 2013 | Exp Neurol2013，244，： | 1 |
| 14 | Cerebral necrosis after 25 Gy radiotherapy in childhood followed 28 years later by 54 Gy radiotherapy显示文摘 | Knot RW Stalpers LJ Aronica E | 2007 | Clin Neurol Neurosurg2007，109，： | 1 |
| 15 | Differential expression patterns of chloride transporters, Na+-K+ -2Cl- - cotransporter and K+ - Cl - - cotransporter, in epilepsy-associated malformations of cortical development 显示文摘 | Aronica E Boer K Redeker S | 2007 | Neuroscience2007，145，1： | 1 |
| 16 | Familial cortical tremor with epilepsy and cerebellar pathological findings 显示文摘 | Van Rootselaar AF Aronica E Jansen Steur EN | 2004 | Mov Disord2004，19，： | 1 |
| 17 | Role of blood-brain harrier in tem- poral lobe epilepsy and pharmaeoresistanee 显示文摘 | Van Vliet EA Aronica E Gorter JA | 2014 | Neuroscienee2014，277，： | 1 |
| 18 | The clinicopathologicspectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission显示文摘 | Blumcke I Thorn M Aronica E | 2011 | Epilepsia2011，52，1： | 1 |
| 19 | Ex-pression of multldrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats显示文摘 | van Vliet EA Redeker S Aronica E | 2005 | Epilepsia2005，46，10： | 1 |
| 20 | Expression pattern of miR- 146a, an inflammation-associated mieroRNA, in experimentaland human temporal lobe epilepsy显示文摘 | Aronica E Fluiter K Iyer A | 2010 | Eur J Neurosci2010，31，6： | 1 |
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