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| 1 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 2 | Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children 显示文摘 | Corsino Rey Marta Los Arcos Andr e s Concha | 2007 | Intensive Care Med2007，33，3： | 1 |
| 3 | Vulnerability to chosen-cyphertext attacks of optical encryption schemes based on double random phase keys显示文摘 | Carnicer A Montes U Arcos S | 2005 | Optics Letters2005，30，13： | 1 |
| 4 | Genetic parameter estimates for reproductive traits and egg composition in Pacific white shrimp Penaeus (Litopenaeus) vannamei显示文摘 | ARCOS F G RACOTTA I S IBARRA A M | 2004 | Aquaculture2004，236，： | 1 |
| 5 | On self-healing key distribution schemes显示文摘 | BLUNDO C D'ARCO P DE S A | 2006 | IEEE Transactions on information Theory2006，52，12： | 1 |
| 6 | Preliminary static analysis of suspension bridges显示文摘 | COBO DEL ARCO D APARICIO A S | 2001 | Engineering Structures2001，23，9： | 1 |
| 7 | Energy Storage Man- agement as Key Issue in Control of Power Systems in Future All Electric Ships显示文摘 | Monti A D'Arco S Gao L | 2008 | IEEE Transactions on Magnetics2008，23，12： | 1 |
| 8 | Genetic analyses and molecular characterization of the pathways involved in the conversion of 2-phenylethylamine and 2-phenylethanol into phenylacetic acid in Pseudomonas putida U显示文摘 | Arias S Olivera E R Arcos M | 2008 | Environ Microbiol2008，10，2： | 1 |
| 9 | Regioselective analysis of the fatty acid composition of triacylglycerols with conventional high performance liquid chromatography显示文摘 | ARCOS J A GARCIA H S HILL C G | 2000 | J Am Oil Chem Soc2000，77，5： | 1 |
| 10 | Alternative splicing generates a novel non-secretable resistin isoform in Wistar rats显示文摘 | Del Arco A Peralta S Cattascosa J M | 2003 | FEBS Lett2003，555，2： | 1 |
| 11 | Control of the triple chaotic attractor in aCournot triopoly model显示文摘 | Hendrik R Arco S | 2004 | Chaos Solitions and Fractals2004，20，： | 1 |
| 12 | The 2002 IAEA test spectra for low-level y-ray spectrometry software显示文摘 | Los ARCOS L J M BLAAUW M FAZINIC S | 2005 | Nuclear Instru- ments and Methods in Physics Research A2005，536，12： | 1 |
| 13 | The jack mackerel fishery and EI Nino 1997-98 effects off Chile显示文摘 | ARCOS D F CUBILLOS L A NUNEZ S P | 2001 | Progress in Oceanography2001，49，： | 1 |
| 14 | Vulnerability to chosen-cyphertext attacks of optical encryption schemes based on double random phase keys显示文摘 | Carnicer A Montes-Usategui M Arcos S Juvells I | 2005 | Opt Lett2005，30，13： | 1 |
| 15 | Mechanical behavior and microstructural analysis of sugarcane bagasse fibers reinforced polypropylene composites显示文摘 | S M Luz A R Goncalves A P Del'Arco Jr | | 0，，38： | 1 |
| 16 | Vulnerability to chosen-cyphertext attacks of optical encryption schemes based on double random phase keys显示文摘 | MONTES-USATEGUI M ARCOS S | 2005 | Optical Letter2005，30，： | 1 |
| 17 | Clinicopathological differences,risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer显示文摘BACKGROUND In the molecular era,the Laurén system is still a cost-effective and widely implemented classification for gastric cancer(GC)and it has been recently associated with clinical,histological and molecular features of these tumors.Despite recent advances in the understanding of the molecular biology of GC,there is a need to develop new prognostic tools for patient stratification in clinical practice.Thus,the identification of easily available prognostic factors in patients with intestinal and diffuse-type tumors can significantly improve risk assessment and patient stratification in GC.AIM To identify clinicopathological differences,risk factors,and to develop costeffective prognostic scores for patients with intestinal and diffuse-type GC.METHODS Retrospective study of all patients undergoing surgery for GC at a tertiary referral center from 2001 to 2019.286 cases met inclusion criteria(intestinal:190,diffuse:96).Clinical data and gross findings were collected.All specimens were reviewed by two independent pathologists and a detailed protocol for histologic evaluation was followed.Five tissue microarrays(TMAs)were constructed and sections of the TMA block were immunostained for HERCEPTEST,MSH2,MSH6,MLH1 and PMS2.Statistical analyses were performed and prognostic scores were developed based on hazard ratios.RESULTS Intestinal and diffuse-type GC showed different epidemiological,clinicopathological and prognostic features.Diffuse tumors were significantly associated with younger age,less symptomatology,flat morphology,deeper invasion,perineural infiltration,advanced stage at diagnosis,administration of adjuvant therapy and poorer prognosis.Intestinal lesions were fungoid or polypoid,showed necrosis,desmoplasia,microsatellite instability and HERCEPTEST positivity and were diagnosed at earlier stages.Tumor depth,desmoplasia,macroscopic type and lymph node involvement were independently related to the Laurén subtype.Furthermore,intestinal and diffuse GC were associated with different risk factors for progression and death.Vascular invasion,perineural infiltration and growth pattern were important prognostic factors in intestinal-type GC.On the contrary,tumor size and necrosis were significant prognosticators in diffuse-type GC.Our recurrence and cancer-specific death scores for patients with intestinal and diffuse-type GC showed an excellent patient stratification into three(diffuse GC)or four(intestinal)prognostic groups.CONCLUSION Our findings support that Laurén subtypes represent different clinicopathological and biological entities.The development of specific prognostic scores is a useful and cost-effective strategy to improve risk assessment in GC. | Cristina Díaz del Arco Lourdes Estrada Muñoz Luis Ortega Medina Elena Molina Roldán MÁngeles Cerón Nieto Soledad García Gómez de las Heras M Jesús Fernández Aceñero | 2022 | World Journal of Gastrointestinal Oncology2022，14，6： | 1 |
| 18 | Antioxidants and AP-1 activation:a brief overview 显示文摘 | Del Arco P G Martine-Martinez S Calvo V | 1997 | Immuno Biology1997，198，： | 1 |
| 19 | The jack mackerel fishery and El Nino 1997-98 effects off Chile显示文摘 | ARCOS D F CUBILLOS L A N U N EZ S P | 2001 | Progress in Oceanography2001，49，： | 1 |
| 20 | Simultaneous determination of antimony( Ⅲ ) and antimony( Ⅴ ) by UV - vis spectroscopy and partial least squares method (PLS) 显示文摘 | JES U S GOMEZ GONZALEZM DOMINGUEZ RENEDO O JULIA ARCOS MARTINEZ M | 2005 | Talanta2005，68，1： | 1 |
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