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| 1 | Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy显示文摘AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIL) intriple-negative-breast-cancer(TNBC).METHODS TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIL levels than those without pCR(P = 0.6331). NAC produced a TIL decrease in full-face sections(P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with pCR.CONCLUSION TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related. | Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez Henry Guerra Carlos Barrionuevo Ketty Dolores-Cerna Carolina Belmar-Lopez Julio Abugattas Gabriela Calderon Miguel De La Cruz Manuel Cotrina Jorge Dunstan Henry L Gomez Tatiana Vidaurre | 2016 | World Journal of Clinical Oncology2016，7，5： | 6 |
| 2 | HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells显示文摘 | PIETRAS R J ARBOLEDA J REESE D M | 1995 | Oncogene1995，10，12： | 1 |
| 3 | Overexpression of Akt2/protein kinase Bbeta leads to up-regulation of betal inte- grins, increased invasion, and metastasis of human breast and ovarian cancer cells显示文摘 | Arboleda M J Lyons J F Kabbinavar F F | 2003 | Cancer Res2003，63，1： | 1 |
| 4 | Exome sequencing for the diagnosis of 46,XY disorders of sex development 显示文摘 | Baxter RM Arboleda VA Lee H | 2015 | J Clin Endocrinol Metab2015，100，2： | 1 |
| 5 | Overexpression of Akt2 protein kinase beta leads to up-regulation of betal integrins increased invasion,and metastasis of human breast and ovarian cancer cells显示文摘 | Arboleda M J Lyons J F Kabbinavar F F | 2003 | Cancer Res2003，63，2： | 1 |
| 6 | Overexpression of AKT2/protein kinasebβ leads to up-regulation of β1 integrins,increased invasion,and metastasis of human breast and ovarian cancer cells显示文摘 | ARBOLEDA M J LYONS J F KABBINAVAR F F | | 0，，01： | 1 |
| 7 | Overexpression of A KT2/protein kinase Bbeta leads to upregulation of betalintegrins,increased invasion,and metastasis of human breast and ovarian cancer cells显示文摘 | ARboleda MJ Lyons JF Kabbinavar FF | 2003 | Cancer Res2003，63，1： | 1 |
| 8 | Her-2/neu and Urokinase-type plasminogen activatior and its inhibitor in breast cancer显示文摘 | Konecny G Untch M Arboleda J | 2001 | Clin Cancer Res2001，7，8： | 1 |
| 9 | Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of betal integrins,increased invasion,and metastasis of human breast and ovarian cancer cells显示文摘 | Arboleda MJ Lyons JF Kabbinavar FF | 2003 | Cancer Res2003，63，： | 1 |
| 10 | Her-2/neu and Urokinase-type plasminogen activator and its inhibitor in breast cancer显示文摘 | Konecny G Untch M Arboleda J | 2001 | J Clin Cancer Res2001，7，8： | 1 |
| 11 | Overexpression of Akt2 protein kinase beta leads to up-regulation of betal integrins increased invasion,and metastasis of human breast and ovarian cancer cells显示文摘 | Arboleda MJ Lyons JF Kabbinavar FF | 2003 | Cancer Res2003，63，： | 1 |
| 12 | Epidemiology Risk factors and genetic influence 显示文摘 | Pin Arboledas G Rosello AL Alarco MC | 2010 | ActaOtorrinolaringolEsp2010，61，1： | 1 |
| 13 | overexpression of AKT2/protein kinase Bβ leads up-regulation of β1 inegrins, increased invasion, and metastasis of human breast and ovarian cancer cells显示文摘 | Arboleda MJ Lyons iF Kabbinavar FF | 2003 | Cancer Res2003，63，1： | 1 |
| 14 | HER-2 typrosine kinase pathway targests estrogen receptor and promotes hormone-independent growth in human breast cancer cells显示文摘 | Arboleda J Reese DM | 1995 | Oncogene1995，10，12： | 1 |
| 15 | Overexpression of AKT2/protein kinase Bbeta leads to up regulation of beta1integrins,increased invasion,and metastasis of human breast and ovarian cancer cells显示文摘 | Arboleda MJ Lyons JF Kabbinavar FF | 2003 | Cancer Res2003，63，1： | 1 |
| 16 | Breeding for efficiency of egg production 显示文摘 | Nordskog A W French H L Arboleda C R | 1972 | World Poult Sci J1972，29，： | 1 |
| 17 | Surgical repair of the anomalous origin of the right puhnonarT artery from the ascending aorta显示文摘 | Arboleda M Nino de Guzman I Ticuna E | 2004 | Arq Bras Cardiol2004，83，6： | 1 |
| 18 | Regulation of ceramide-induced neuronal death:cell metabolism meets neurodegeneration显示文摘 | Arboleda G Morales LC Benitez B | 2009 | Brain Res Rev2009，59，2： | 1 |
| 19 | Association study ofpolymorphisms in LRP1,tau and 5-HTT genes and Alzhei-merfe disease in a sample of Colombian patients显示文摘 | Forero DA Arboleda G Yunis JJ | 2006 | J Neu-ral Transm2006，113，9： | 1 |
| 20 | HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells显示文摘 | Arboleda J Reese DM | 1995 | Oncogene1995，10，12： | 1 |
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