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| 1 | Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies显示文摘Globally,gastric cancer is the 4thmost frequently diagnosed cancer and the 2ndleading cause of death from cancer,with an estimated 990000 new cases and738000 deaths registered in 2008.In the advanced setting,standard chemotherapies protocols acquired an important role since last decades in prolong survival.Moreover,recent advances in molecular therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2(HER2)therapies.Trastuzumab,an anti-HER2 monoclonal antibody,was the first target drug in the metastatic setting that showed benefit in overall survival when in association with platinum-5-fluorouracil based chemotherapy.Further,HER2 overexpression analysis acquired a main role in predict response for trastuzumab in this field.Thus,we conducted a review that will discuss the main points concerning trastuzumab and HER2 in gastric cancer,providing a comprehensive overview of molecular mechanisms and novel trials involved. | Michael Luis Ana Tavares Liliana S Carvalho Lúcio Lara-Santos António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，38： | 6 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Anti-angiogenic therapies for metastatic colorectal cancer:Current and future perspectives显示文摘Colorectal cancer(CRC)is the fourth most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in the United States,with about 142820 new cases and 50830 deaths expected in 2013.Metastatic disease(mCRC)remains a challenge for oncologists worldwide due to its potential comorbidities.Recently,chemotherapy regimens containing 5-fluorouracil,leucovorin,oxaliplatin and irinotecan combinations are a standard of care in the metastatic disease.Currently,biological therapies involving vascular endothelial growth factor and epidermal growth factor receptor pathways,such as bevacizumab and cetuximab,have emerged as good option for improving mCRC patient survival.Now,aflibercept plus standard chemotherapy has also been approved in second line regimen for mCRC patients.Our review will discuss novel biological drugs and their indications for mCRC patients and will bring future perspectives in this regard. | Inês Marques António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，44： | 3 |
| 4 | Assessment of air pollution genotoxicity by RAPD in Evernia prunastri L. Ach. from around iron-steel factory in Karabk, Turkey显示文摘Lichens are widely used in biomonitoring studies of air pollution, either as bioindicators of air quality or as bioaccumulators of atmospheric deposition. Over the past decade, several molecular techniques have been developed to provide information on diversity, genotoxicology, genetic relationships, etc. The heavy metal contents of Evernia prunastri samples were determined by atomic absorption spectrometry. The Random Amplified Polymorphic DNA Polymerase Chain Reaction (RAPD-PCR) method was used to describe the pattern of DNA band variation in the samples influenced by the environmental pollution. The study was designed to describe the level of pollution in an area contaminated with smoke and waste from an iron-steel factory, and to reveal the level of potential genotoxic agents around this source of pollution. The study also examined the suitability of the lichen samples for the detection of genotoxicity. | Demet Cansaran-Duman Orhan Atakol Smer Aras | 2011 | Journal of Environmental Sciences2011，23，7： | 2 |
| 5 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 6 | Sexual attitudes,behaviour changesand opinions of interns in Izmir,Turkey显示文摘 | Ozan S Timbil S Aras S | 2010 | Eur J Contracept Re-prod Health Care2010，15，5： | 1 |
| 7 | Structural and Magnetic Study of Self-doped La1-x-yCaxφyMnO3显示文摘 | Figueiras F Araùjo J P Amaral V S | 2004 | Journal of Magnetism and Magnetic Materials2004，，： | 1 |
| 8 | Serum level of lipoprotein (a) is inversely associated with the development of coronary collateral circulation 显示文摘 | Aras D Geyik B Topaloglu S | 2006 | Coron Artery Dis2006，17，2： | 1 |
| 9 | Efficacy of micronized flavonoid fraction in healing of clean and infected wounds 显示文摘 | Hasanoglu A Ara C Ozen S | 2001 | Int J Angiol2001，10，1： | 1 |
| 10 | Living Donor Liver Transplantation for Acute Liver Failure: A Single Center Experience显示文摘 | L.P. Cariús L.F. Pacheco-Moreira E. Balbi C.R.G. Leal A.C. Gonzalez L.V. Agoglia C. Araújo M. Enne J.M. Martinho | 2009 | Transplantation Proceedings2009，，3： | 1 |
| 11 | Spontaneous intestina perforation due to non-Hodgkin's lymphoma:evaluation o eight cases显示文摘 | Ara C Coban S Kayaalp C | 2007 | Dig Dis Sci2007，52，8： | 1 |
| 12 | Investigating for insulin re- sistance and type 2 diabetes mellitus in obese children显示文摘 | Simsek E Karabay E Aras S | 2005 | Turk J Endo Metab2005，1，2： | 1 |
| 13 | Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment显示文摘 | Santos L H M L M Araújo A N Fachini A Pena A Delerue-Matos C Montenegro M C B S M | | 0，，： | 1 |
| 14 | Detoxification of the herbicide propanil by means of Fenton process and Ti O2-photocatalysis显示文摘 | O M G S Araa J González D O | 2014 | Journal of Photochemistry and Photobiology A2014，219，： | 1 |
| 15 | Plasma level of soluble P - selectin in patients with rheumatic mitral stenosis and sinus rhythm undergoing percutaneous mitral balloon valvuloplasty 显示文摘 | TOPALOGLU S ARAS D ERGUN K | 2007 | J Thromb Thrombolysis2007，23，3： | 1 |
| 16 | QT dispersion significantly increases after implantable cardioverter-defibrillator shocks 显示文摘 | Topaloglu S Aras D Sahin O | 2007 | Ann Noninvasive Electrocardiol2007，12，1： | 1 |
| 17 | Feasibility of extraperitoneal laparoscopic para-aortic and com m on iliac lym phadenectom y显示文摘 | NAGAO S FUJIW ARA K KAGAW A R | 2006 | Gynecol Oncol2006，103，2： | 1 |
| 18 | Dissolution kinetics of sphalerite in acidic ferric chloride leaching 显示文摘 | Aydogan S Aras A Canbazoglu M | 2005 | Chemical Engineering Journal2005，114，13： | 1 |
| 19 | The significance of admission hs-CRP in patients undergoing primary percutaneous intervention for acute myocardial infarction显示文摘 | Cagli KE Topaloglu S Aras D | 2009 | Turk Kardiyol Dern Ars2009，37，1： | 1 |
| 20 | Stored platelets contain residual amounts of tissue factor:evidence from studies on platelet concentrates stored for prolonged periods显示文摘 | Perez-Pujol S Aras O Lozano M | 2005 | Transfusion2005，45，4： | 1 |
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