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| 1 | Effects of a 3-month vigorous physical activity intervention on eating behaviors and body composition in overweight and obese boys and girls显示文摘Purpose: This study aims to analyze the effects of a 3-month vigorous physical activity(VPA) intervention on eating behavior and body composition in overweight and obese children and adolescents.Methods: Forty-seven participants(7–16 years) took part in the study: 28 were assigned to the intervention group(IG)(10 boys and 18 girls) and19 in a control group(CG)(8 boys and 11 girls). Body composition(dual-energy X-ray absorptiometry), anthropometrics(body mass, height, and body mass index(BMI)), and eating behavior traits(Three-Factor Eating Questionnaire-R21 C) were determined before and after the VPA intervention.Results: A decrease in the percentage of body fat and BMI(-2.8% and-1.8%, respectively), and an increase in most lean mass variables were found in the IG(all p ≤ 0.05). In relation to the eating behavior traits, IG subjects showed a 14% reduction in the Emotional Eating score(p = 0.04),while Cognitive Restraint score did not change after the VPA intervention. The baseline factors of the questionnaire predicted changes in body mass and fat mass variables only in the CG.Conclusion: A 3-month VPA intervention influenced eating behaviors of overweight or obese young, especially the Emotional Eating factor, in the presence of favorable body composition changes. | María Martín-García Luis M.Alegre Beatriz Garcia-Cuartero Eleanor J.Bryant Bernard Gutin Ignacio Ara | 2019 | Journal of Sport and Health Science2019，8，2： | 4 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Immunohistochemical study of the digestive tract of Oligosarcus hepsetus显示文摘AIM: To describe the histology of the digestive tract and to investigate the occurrence of endocrine cells in Oligosarcus hepsetus (O. hepsetus ). METHODS: The digestive tract (DT) of O. hepsetus was divided into esophagus, two stomach regions (glandular and non-glandular) and two intestinal regions (anterior and posterior). These specimens were processed by routine histological techniques and stained with hematoxylin-eosin, Gomori's trichrome, periodic acid Schiff (PAS) and Alcian blue (AB). An immunohistochemical method using avidin-biotin-peroxidase was employed.RESULTS: The esophagus is lined with a non-keratinized stratified squamous epithelium that is reactive to PAS and AB. The stomach has a mucosa lined with a simple columnar epithelium with mucus-secreting cells that are reactive only to PAS. The intestine has a simple columnar epithelium with a brush border and goblet cells that are reactive to PAS and AB. Somatostatin, serotonin and cholecystokinin immunoreactive cells were identified throughout the DT.CONCLUSION: This study revealed adaptations for the species' diet and showed that the distribution and relative frequency of immunoreactive cells are similar to those of other fish. | Danielle A Vieira-Lopes Nadja L Pinheiro Armando Sales Adriana Ventura Francisco G Araújo Iracema D Gomes Aparecida A Nascimento | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 4 | Helicobacter pylori infection:How does age influence the inflammatory pattern?显示文摘The inflammatory pattern during Helicobacter pylori(H.pylori)infection is changeable and complex.During childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor FOXP3.On the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among H.pylori-positive adults.In the last few years,the participation of the Th17 response in the gastric inflammation against H.pylori infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the infection.Moreover,this cytokine profile might play a pivotal role in the effectiveness of anti-H.pylori vaccines.It is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with H.pylori,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism. | Glauber Rocha Lima Araújo Hanna Santos Marques Maria Luísa Cordeiro Santos Filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa Santos Fabrício Freire de Melo | 2022 | World Journal of Gastroenterology2022，28，4： | 2 |
| 5 | 左心房结构和功能改变可早期预测无症状高血压患者左心室功能不全显示文摘该研究旨在探索无症状高血压患者左心房结构和功能改变与左心室功能不全之间的关系。入选左心室射血分数(1eft ventricular ejection fraction,LVEF)≥60%的无症状高血压患者126例。应用常规脉冲组织多普勒及二维斑点追踪超声心动图(two-dimensional speckle—tracking echocardiography,2DSTE)检测和分析左心房结构与功能改变的独立影响因素。 | Miyoshi H Oishi Y Mizuguchi Y Iuchi A Nagase N Ara N Oki T 刘莉 叶鹏 | 2013 | 中华高血压杂志2013，21，5： | 2 |
| 6 | Posterior fossa epidural hema- tomas in children: clinical experience with 40 cases显示文摘 | Seneer A Aras Y Akcakaya MO | 2012 | Neurosurg Pediatr2012，9，2： | 1 |
| 7 | Silicone oil in the surgical treatment of endophthalmitis associated with retinal detachment 显示文摘 | Aras C Ozdamar A Karacorlu M | 2001 | lnt Ophthalmol2001，24，3： | 1 |
| 8 | Vertical changes following orthodontic extraction treatment in skeletal open bite subjects显示文摘 | Aras A | 2002 | Europ J Orthod2002，24，10： | 1 |
| 9 | Efficacy of micronized flavonoid fraction in healing of clean and infected wounds 显示文摘 | Hasanoglu A Ara C Ozen S | 2001 | Int J Angiol2001，10，1： | 1 |
| 10 | Effects of transmandibular symphyseal distraction on teeth, bone, and temporomandibular joint 显示文摘 | Gunbay T Akay MC Aras A | 2009 | J Oral Maxillofac Surg2009，67，10： | 1 |
| 11 | Mathematical modeling of flow on 2D and 3D vascular networks: Applications to anti-angiogenic and chemotherapeutic drug strategies 显示文摘 | Ste'phanou A Mcdougall SR Anderson ARA | 2005 | Math Comp Mod2005，41，： | 1 |
| 12 | Changes in tear flow and tear film stabilityafter photo refractive keratectomy 显示文摘 | Ozdamar A Aras C Karakas N | 1999 | Cornea1999，18，： | 1 |
| 13 | Scleral buckling with a noncontact wide-angle viewing system显示文摘 | Aras C Ucar D Koytak A | 2012 | Ophthalmologica2012，227，2： | 1 |
| 14 | In vitro antimicrobial activity of silicone oil against endophthalmitis causing agents显示文摘 | Ozdamar A Aras C Ozturk R | 1999 | Retina1999，19，2： | 1 |
| 15 | Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment显示文摘 | Santos L H M L M Araújo A N Fachini A Pena A Delerue-Matos C Montenegro M C B S M | | 0，，： | 1 |
| 16 | Detoxification of the herbicide propanil by means of Fenton process and Ti O2-photocatalysis显示文摘 | O M G S Araa J González D O | 2014 | Journal of Photochemistry and Photobiology A2014，219，： | 1 |
| 17 | Ecotoxicological aspectsrelated to the presence of pharmaceuticals in the aquatic environment显示文摘 | SANTOS L H ARAJO A N FACHINI A | 2010 | J Hazard Mater2010，175，13： | 1 |
| 18 | Feasibility of extraperitoneal laparoscopic para-aortic and com m on iliac lym phadenectom y显示文摘 | NAGAO S FUJIW ARA K KAGAW A R | 2006 | Gynecol Oncol2006，103，2： | 1 |
| 19 | Dissolution kinetics of sphalerite in acidic ferric chloride leaching 显示文摘 | Aydogan S Aras A Canbazoglu M | 2005 | Chemical Engineering Journal2005，114，13： | 1 |
| 20 | Simple rigid plastic model for seismic tilting of rigid walls 显示文摘 | Siddharthan R Ara A Norris G M | 1989 | Journal of Structural Engineering ASCE1989，118，： | 1 |
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