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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Enzymatic hydrolysis of cellulosic mixture of Aspergillus aculestus and Trichoderma viride, and ethanol production from the hydrolyzate显示文摘 | Hayashi H Arai M | 1983 | Hakkokogaku1983，61，： | 2 |
| 3 | Catalytic properties of BaMA11O19(M=Cr, Mn, Fe, Ni) for high temperature catalytic combustion显示文摘 | Machida M Eguchi K Arai H | 1989 | Journal of Catalysis1989，，120： | 1 |
| 4 | Hypercholesterolemiacontributes to the development of atherosclerosis and vas-cular remodeling by recruiting bone marrow-derived cellsin cuff-induced vascular injury显示文摘 | Xu Y Arai H Murayama T | 2007 | Biochem Biophys ResCommun2007，363，3： | 1 |
| 5 | The amount of immature glial cells in organotypic brain slices determines the susceptibility to murine cytomegalovirus infection 显示文摘 | Kawasaki H Kosugi I Arai Y | 2002 | Lab Invest2002，82，10： | 1 |
| 6 | Catalytic properties of BaMAl11O19-α (M = Cr, Mn, Fe, Co, and Ni) for high-temperature catalytic combustion显示文摘 | Machida M Eguchi K Arai H | 1989 | Journal of Catalysis1989，120，： | 1 |
| 7 | Urinary Smadl is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy显示文摘 | Mima A Arai H Matsubara T | 2008 | Diabetes2008，57，6： | 1 |
| 8 | Hemorheological and hemodynamic anolysis of hypervolemic hemolution therapy for cerebrai vasospasm after aneurismal subarachnoid hemorrhage显示文摘 | Mori K Arai H Nakajima K | 1995 | Stroke1995，26，： | 1 |
| 9 | Thermal behavior of Li1y NiO2 and the decomposition mechanism显示文摘 | Arai H Okada S Sakurai Y | 1998 | Solid State Ionics1998，109，： | 1 |
| 10 | Low Temperature Oxidation of Methane over Pd-Based Catalysts-Effect of Support Oxide on the Combustion Activity 显示文摘 | Eguchi K Arai H | 2001 | Appl Catal A2001，222，12： | 1 |
| 11 | Expression of nNOS and soluble guanylate cyclase in schizophrenic brain显示文摘 | Baba H Suzuki T Arai H | 2004 | Neuroreport2004，15，： | 1 |
| 12 | Electrochemical and thermal behavior of LiNi1-zMzO2 (M = Co,Mn,Ti)显示文摘 | ARAI H OKADA S SAKURAI Y | 1997 | J Electrochem Soc1997，144，： | 1 |
| 13 | Establishment of a diabetic mouse model with progressive diabetic nephropathy显示文摘 | Inada A Nagai K Arai H | 2005 | Am J Pathol2005，167，2： | 1 |
| 14 | Isothermal imidization of an aromatic polyimide precursor studied by fluorescence spectroscopy显示文摘 | Hasegawa M Arai H Mira I | 1990 | Polym J1990，22，10： | 1 |
| 15 | gosinophilic granulorna of bone: two case reports显示文摘 | Oguro K Sakai H Arai M | 2013 | Brain Dev2013，35，4： | 1 |
| 16 | Vitamin E inhibits oxidative stress-induced denaturation of nerve terminal proteins involved in neurotransmission 显示文摘 | Kaneai N Arai M Takatsu H | 2012 | J Alzheimers Dis2012，28，1： | 1 |
| 17 | Simple camera calibration from a single image using five points on two orthogonal 1-d objects显示文摘 | MIYAGAWA I ARAI H KOIKE H | 2010 | IEEE Transactions on Image Processing2010，19，6： | 1 |
| 18 | Numerical simulation of piston ring in mixed lubrication - a nonaxisymmetrical analysis 显示文摘 | Hu Y Z Cheng H S Arai T | 1994 | Transaction of ASME1994，116，： | 1 |
| 19 | Effect of edaravone, a free radical scavenger on ischemic cerebral edema assessed by magnetic resonance imaging显示文摘 | Suda S Igarashi H Arai Y | 2007 | Neurol Med Chir2007，47，： | 1 |
| 20 | Microarray analysis of temporal gene responses to ionizing radiation in two glioblastoma cell lines: up-regulatlon of DNA repair genes显示文摘 | OTOMO T HISHII M ARAI H | 2004 | J Radiat Res (Tokyo)2004，45，1： | 1 |
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