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| 1 | Cytokine and apoptosis gene polymorphisms influence the outcome of hepatitis C virus infection显示文摘BACKGROUND:Hepatitis C virus (HCV) infection is thought to be chronic and the factors leading to viral clearance or persistence are poorly understood.This study was undertaken to investigate the possibility of a significant relationship between the spontaneous clearance or the persistence of hepatitis C virus (HCV) infection and cytokine and apoptosis gene polymorphisms in Tunisian patients on hemodialysis.METHODS:Polymorphisms of the genes IL-1 (-889 IL-1α,-511 and +3954 IL-1β,IL-1Ra),IL-18 (-137 and-607),IL-12 (-1188) and Apo1/Fas (-670) were determined by PCR-RFLP,PCR-SSP and PCR-VNTR in 100 healthy blood donors and 100 patients infected with HCV and undergoing hemodialysis.The patients were classified into two groups:G1 consisted of 76 active chronic hepatitis patients (positive for HCV RNA) and G2 consisted of 24 hemodialysed patients who spontaneously eliminated the virus (negative for HCV RNA).RESULTS:The frequency of genotype association [-137GC/-607CA] IL-18 was higher in G2 (41.7%) than in G1 (15.8%) (P=0.008;OR=0.26;95% CI,0.10-0.73).We also found a higher frequency of the AA genotype of the Apo1/Fas gene in G2 (41.6%) than in G1 (17.5%) (P=0.026;OR=3.49;95% CI,1.13-10.69).Adjustment for known covariate factors (age,gender and genotype) confirmed these univariate findings and revealed that the genotype association GC-CA of the (-137 and-607) IL-18 gene and the AA genotype of the Apo1/Fas gene were associated with the clearance of HCV (P=0.041 and 0.017,respectively).CONCLUSION:The two genotypes GC-CA of the (-137 and-607) IL-18 polymorphism and the AA genotype of the Apo1/Fas gene influence the outcome of HCV infection in Tunisian patients on hemodialysis. | Leila Ksiaa Cheikhrouhou Imen Sfar Hajer Aounallah-Skhiri Houda Aouadi Salwa Jendoubi-Ayed Taieb Ben Abdallah Khaled Ayed Yousr Lakhoua-Gorgi | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 4 |
| 2 | Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD显示文摘AIM: To detect a possible association between the polymorphism of the (-670 A/G) Fas/Apo1 gene promoter and susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) in the Tunisian population. METHODS: The (-670 A/G) Fas polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the polymerase chain reaction restriction fragment length polymorphism method. RESULTS: Significantly lower frequencies of the Fas -670 A allele and A/A homozygous individuals were observed in CD and UC patients when compared with controls. Analysis of (-670 A/G) Fas polymorphism with respect to sex in CD and UC showed a significant difference in A/A genotypes between female patients and controls (P corrected = 0.004 in CD patients and P corrected = 0.02 in UC patients, respectively). Analysis also showed a statistically significant association between genotype AA of the (-670 A/G) polymorphism and the ileum localization of the lesions (P corrected = 0.048) and between genotype GG and the colon localization (Pcorrected = 0.009). The analysis ofinflammatory bowel disease patients according to clinical behavior revealed no difference. CONCLUSION: Fas-670 polymorphism was associated with the development of CD and UC in the Tunisian population. | Walid Ben Aleya Imen Sfar Leila Mouelhi Houda Aouadi Mouna Makhlouf Salwa Ayed-Jendoubi Samira Matri Azza Filali Taoufik Najjar Taeib Ben Abdallah Khaled Ayed Yousr Gorgi | 2009 | World Journal of Gastroenterology2009，15，29： | 3 |
| 3 | Natural evolution of hepatitis C virus infection in hemodialysis Tunisian patients and CTLA-4 SNP's显示文摘AIM: To analyze the polymorphisms of CTLA-4 gene involved in the response against hepatitis C virus(HCV) infection.METHODS: We recruited 500 hemodialysed patients from several hemodialysis centers, all HCV-antibody positive, spread over different regions of Tunisia, as part of a national survey in 2008 conducted in the laboratory of immunology at the Charles Nicolle hospital Tunisia, classified into two groups G1(PCR+) and G2(PCR-) according to the presence or absence of viral RNA. Of these patients, 307 were followed prospectively on a viral molecular level over a period from 2002 to 2008, divided into two groups based on the persistence and viral clearance. PCR-RFLP was performed for the analysis of SNPs(+49) A/G and(+6230) G/A CTLA-4 for these 500 patients and 358 healthy controls.RESULTS: Analysis of clinical and virological charac-teristics of our cohort suggests a nosocomial infection in our hemodialysed patients with transfusion history as a primary risk factor and a predominance of genotype 1b. The haplotype analysis revealed an increase of frequencies of GG(+49)/(CT60) CTLA-4 in the entire patients group compared to controls(P = 0.0036 and OR = 1.42; 95%CI: 1.12-1.79, respectively). This haplotype is therefore associated with susceptibility to HCV infection. CONCLUSION: Our study suggests a possible role of CTLA-4 polymorphisms in the outcome of HCV infection in the Tunisian hemodialysed population. | Leila Ksiaa Cheikhrouhou Yousr Lakhoua-Gorgi Imen Sfar Salwa Jendoubi-Ayed Houda Aouadi Mouna Makhlouf Khaled Ayed Taieb Ben Abdallah | 2015 | World Journal of Gastroenterology2015，21，35： | 2 |
| 4 | p38 mitogen-activated protein kinase activity commits embryonic stem cells to either neurogenesis or cardiomyogenesis 显示文摘 | Aouadi M Bost F Caron L | 2006 | Stem Cells2006，24，： | 1 |
| 5 | P38 mitogen activated protein kinase activity commits embryonic stem cells to ei- ther neurogenesis or cardiomyogenesis 显示文摘 | Aouadi M Bost F Caron L | 2006 | Stem Cells2006，24，： | 1 |
| 6 | Cement-bonded straw board subjected to accelerated processing显示文摘 | Soroushian P Aouadi F Chowdhury H | 2003 | Cement and Concrete Composites2003，26，7： | 1 |
| 7 | Role of MAPKs in development and differentiation:lessons from knockout miee显示文摘 | Aouadi M Binetnly B Caron L Le Marchand-Brustel Y Bost F | 2006 | Biochimie2006，88，9： | 1 |
| 8 | HIF-2αblows out the flames of adipose tissue macrophages to keep obesity in a safe zone显示文摘 | Aouadi M | 2014 | Diabetes2014，63，10： | 1 |
| 9 | The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis显示文摘 | Bost F Aouadi M Caron L | 2005 | Diabetes2005，54，2： | 1 |
| 10 | p38 mitogen-activated protein kinase activity commiL embryonic stem cells to either neurogenesis cr eardiomyogenesis显示文摘 | Aouadi M Bost F Caron L | 2006 | Stem Cells2006，24，5： | 1 |
| 11 | Inhibition of p38 MAPK increases adipogenesis from embryonic to adult stages 显示文摘 | Aouadi M Laurent K Prot M | 2006 | Diabetes2006，55，2： | 1 |
| 12 | p38MAP Kinase activity is required for human primary adipocyte differentiation显示文摘 | Aouadi M Jager J Laurent K | 2007 | FEBS Lett2007，581，29： | 1 |
| 13 | The role of MAPKs in adipocyte differentiation and obesity显示文摘 | Bost F Aouadi M Caron L | 2005 | Biochimie2005，87，1： | 1 |
| 14 | Effects of environmental exposure on fiber-reinforced plastics (FRP) materials used in construction 显示文摘 | Chin J W Nguyen T Aouadi K | 1997 | Journal of Composites Technology & Research1997，19，4： | 1 |
| 15 | Hybrid Laplace transform-finite element method to a generalized eleetromagneto-thermoelastic problem 显示文摘 | Aouadi M | 2007 | Applied Mathematical Modelling2007，31，： | 1 |
| 16 | The role of MAPKs in adipocyte differentiation and obesity 显示文摘 | BOST F AOUADI M CARON L | 2005 | Biochimie2005，87，1： | 1 |
| 17 | Effects of water,salt solu- tion and simulated concrete pore solution on the properties of com- posite matrix resins used in civil engineering applications 显示文摘 | Chin JW Aouadi K Haight MR | 2001 | Poly- mer composites2001，22，2： | 1 |
| 18 | RNAi based therapeutic str ate- gies for metabolic disease 显示文摘 | Czech MP Aouadi M Tesz GJ | 2011 | Nat Rev Endocrinol2011，7，： | 1 |
| 19 | The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis显示文摘 | Bost F Aouadi M Caron L Even P Belmonte N Prot M Dani C Hofman P Pagès G P | | 0，，02： | 1 |
| 20 | Variable electrical and thermal conductivity in the theory of generalized thermoelastic diffusion显示文摘 | Moncef Aouadi | 2006 | Zeitschrift für angewandte Mathematik und Physik2006，，2： | 1 |
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