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| 1 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Micro-Raman studies on DLC coatings 显示文摘 | Irmer G Annett D R | 2005 | Advanced Engineering Materials2005，8，： | 1 |
| 3 | Production of hepatic outflow block and ascites with an ameroid constrictor 显示文摘 | Sweat E R Musieant M E Annetts D L | 1966 | Surg Forum1966，17，： | 1 |
| 4 | A study on reducing substrates of manganese-oxidizing peroxidases from Pleurotus eryngii and Bjerkandera adusta 显示文摘 | Annette H Francisco J R D Maria J M | 1998 | FEBS Lett1998，428，3： | 1 |
| 5 | The effects of vapreotide, a somatostatin analogue, on gastric acidity, gallbladder emptying and hormone release after 1 week of continuous subcutaneous infusion in normal subjects显示文摘 | MARC A R JURGEN D ANNETTE Z | 1999 | Brit J Clin Pharmacol1999，47，： | 1 |
| 6 | Position of horse- shoe crabs in estuarine food webs: N and C stable isotopic study of foraging ranges and diet composition 显示文摘 | Carmichael R H Rutecki D Annett B | 2004 | Journal of Experimental Marine Biology and Ecology2004，299，2： | 1 |
| 7 | Micro-Raman studies on DLC coatings 显示文摘 | IRMER G ANNETT D R | 2005 | Advanced Engineering Materials2005，，8： | 1 |
| 8 | Electrochemical cor- rosion behaviour of uncoated and DLC coated medical grade Co28Cr6Mo 显示文摘 | Annett D R Schurer C Irmer G | 2004 | Surf Coat Techn2004，，： | 1 |
| 9 | Patients without borders: The emergence of medical tourism显示文摘 | Annette B Arellano R D | 2007 | International Journal of Health Services2007，37，1： | 1 |
| 10 | Factors influencing parent reports on quality of life for children with asthma显示文摘 | ANNETT R D BENDER B G DUHAMEL T R | 2003 | J Asthma2003，40，5： | 1 |
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