|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antihyperglycemic activity,antihyperlipedemic activity,haematological effects and histopathological analysis of Sapindus mukorossi Gaerten fruits in streptozotocin induced diabetic rats显示文摘Objective:To investigate the antihyperglycemic and antihyperlipidemie properties of hydroalcoholic extract of fruits of Sapindus mukorossi Caerlen and its beneficial effect on haeniatological parameters with histopathological analysis in streptpzotocin induced diabetic rats.Methods:Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and standard drug glybenclamide(0.5 mg/kg body weight) were administered to diabetic rats.Effect of extract on hyperglycemia,hyperlipidemia and hematological parameters was studied in diabetic rats.Histopathological changes in diabetic rat pancreas were also observed after extract and glybenclamide treatment.Results:Daily oral administration of Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and glybenclamide for 20 days showed beneficial effects on blood glucose level(P<0.01) and lipid level.The extract has a favorable effect on the histopathological changes of the pancreas in streptozotocin induced diabetes.Conclusions: These findings reveal that the hydroalcoholic extract of Sapindus mukorossi fruits extract possesses antihyperglycemic and antihyperlipidemie properties.In addition.the extract can prevent various complications of diabetes and improve some haeniatological parameters. | Neeraj Verma G Amresh P K Sahu Neelam Mishra Anil P Singh Ch V Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 14 |
| 2 | Pharmacological evaluation of hyperin for antihyperglycemic activity and effect on lipid profile in diabetic rats显示文摘 | Verma N Amresh G Sahu P K | 2013 | Indian Journal of Experimental Biology2013，51，1： | 1 |
| 3 | Hepatoprotective activity of Amaranthus spinosus in experimental animals 显示文摘 | Zeashan H Amresh G Singh S | 2008 | Food Chem Toxieol2008，46，11： | 1 |
| 4 | Antidiarrheal and antiulcer activity of Amaranthus spinosus in experimental animals显示文摘 | Hussain Z Amresh G Singh S Rao CV | 2009 | Pharm Biol2009，47，10： | 1 |
| 5 | Antihyperglycemic and antihyperlipidemic activity of ethyl acetate fraction of Rhododendron arboreum Smith flowers in streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolism显示文摘Objective:To explore and identify the most potent antihyperglycemic fraction from the ethanol extract of Rhododendron arboreum(R.arboreum)flowers.Methods:Normal and streptozotocin induced diabetic rats were treated with all four fractions of R.arboreum flowers for short term and with fraction 3 for long term study.On completion of the treatment,a range of indicators were tested including fasting blood glucose,plasma protein,haemoglobin A1C,insulin secretion,body weight,blood lipid profile and carbohydrate metabolism regulating enzymes of liver.Results:In short term study,the fraction 3(Active fraction)produced a significant(P<0.0001)reduction(73.6%)in blood glucose level at a dose of 200 mg/kg after the treatment in the diabetic rats.Administration of active fraction(200 and 400 mg/kg)once daily for 30 d in streptozotocin diabetic rats resulted in a significant(P<0.001 to P<0.0001)fall in blood glucose level,hemoglobin A1C,serum urea and creatinine with significant but a increase in insulin level similar to standard drug glybenclamide.Further,the active fraction showed antihyperlipidemic activity as evidenced by significant(P<0.001 to P<0.0001)decreases in serum serum total cholesterol,triglycerides,low density lipoprotein cholesterol and very low density cholesterol levels coupled together with elevation of high density lipoprotein cholesterol in the diabetic rats.Conclusions:The active fraction of R.arboreum flowers decreases streptozotocin induced hyperglycemia by promoting insulin secretion and glycolysis and by decreasing gluconeogenesis. | Neeraj Verma G Amresh PK Sahu Ch V Rao Anil Pratap Singh | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，9： | 1 |
| 6 | Hepatoprotective and antioxidant activity of maranthus spinosus against CCl4induced toxicity显示文摘 | ZEASHAN H AMRESH G SINGH S at al | 2009 | J Ethnopharmacol2009，125，2： | 1 |
| 7 | Hepatoprotective and antioxidant activity of Arnaranthus spinosus against CC14 induced toxicity 显示文摘 | Zeashan H Amresh G Singh S | 2009 | J Ethnopharmacol2009，125，2： | 1 |
| 8 | Hepatoprotective activity of Arnaranthus spinosus in experimental animals 显示文摘 | Zeashan H Amresh G Singh S | 2008 | Food Chem Toxieol2008，46，11： | 1 |
| 9 | Antioxidant activity of Cissampelos pareira on benzo(a)pyrene-induced mucosal injury in mice显示文摘 | G Amresh Chandana Venkateswara Rao Paras Nath Singh | 2007 | Nutrition Research2007，，10： | 1 |
| 10 | Hepatoprotective activity of Amaranthus spinosus in experimental animals 显示文摘 | Zeashan H Amresh G Singh S | 2008 | Food and Chemical Toxicology2008，46，11： | 1 |
| 11 | Hepatoproteetive and antioxidant activity of Amaranthus spinosus against CCI4 induced toxicity 显示文摘 | Zeashan H Amresh G Singh S | 2009 | J Ethnopharmacology2009，125，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员