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| 1 | The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease显示文摘Gaucher disease(GD),the commonest lysosomal storage disorder,results from the lack or functional deficiency of glucocerebrosidase(GCase) secondary to mutations in the GBA1 gene.There is an established association between GBA1 mutations and Parkinson's disease(PD),and indeed GBA1 mutations are now considered to be the greatest genetic risk factor for PD.Impaired lysosomal-autophagic degradation of cellular proteins,including α-synuclein(α-syn),is implicated in the pathogenesis of PD,and there is increasing evidence for this also in GD and GBA1-PD.Indeed we have recently shown in a Drosophila model lacking neuronal GCase,that there are clear lysosomal-autophagic defects in association with synaptic loss and neurodegeneration.In addition,we demonstrated alterations in mechanistic target of rapamycin complex 1(mTORC1) signaling and functional rescue of the lifespan,locomotor defects and hypersensitivity to oxidative stress on treatment of GCase-deficient flies with the mT OR inhibitor rapamycin.Moreover,a number of other recent studies have shown autophagy-lysosomal system(ALS) dysfunction,with specific defects in both chaperone-mediated autophagy(CMA),as well as macroautophagy,in GD and GBA1-PD model systems.Lastly we discuss the possible therapeutic benefits of inhibiting mT OR using drugs such as rapamycin to reverse the autophagy defects in GD and PD. | Kerri J.Kinghorn Amir M.Asghari Jorge Iván Castillo-Quan | 2017 | Neural Regeneration Research2017，12，3： | 4 |
| 2 | Inter-ethnic marriages and severity of coronary artery disease:A multicenter study of Arabian Gulf States显示文摘AIM To assess the association of inter-ethnic vs intra-ethnic marriage with severity of coronary artery disease(CAD) in men undergoing angiography.METHODS We conducted a prospective multicenter,multi-ethnic,cross sectional observational study at five hospitals in Saudi Arabia and the United Arab Emirates,in which we used logistic regression analysis with and without adjustment for baseline differences. RESULTS Data were collected for 1068 enrolled patients undergoing coronary angiography for clinical indications during the period of April 1^(st),2013 to March 30^(th),2014. Ethnicities of spouses were available only for male patients. Of those enrolled,687 were married men and constituted the cohort for the present analysis. Intra-ethnic marriages were reported in 70% and inter-ethnic marriages in 30%. After adjusting for baseline differences,interethnic marriage was associated with lower odds of having significant CAD [adjusted odds ratio 0.52(95%CI:0.33,0.81)] or multi-vessel disease(MVD) [adjusted odds ratio 0.57(95%CI:0.37,0.86)]. The adjusted association with left main disease showed a similar trend,but was not statistically significant [adjusted odds ratio 0.74(95%CI:0.41,1.32)]. The association between interethnic marriage and the presence of significant CAD and MVD was not modified by number of concurrent wives(P interaction > 0.05 for both).CONCLUSION Among married men undergoing coronary angiography,inter-ethnic,as compared to intra-ethnic,marriage is associated with lower odds of significant CAD and MVD. | Amin Daoulah Salem Al-kaabi Amir Lotfi Mushabab Al-Murayeh S Ali Nasseri Waleed Ahmed Salah N Al-Otaibi Mohamed N Alama Osama E Elkhateeb Amy J Plotkin Majed M Malak Khalid Alshali Mohamed Hamzi Saleh Al Khunein Mohammed Abufayyah Alawi A Alsheikh-Ali | 2017 | World Journal of Cardiology2017，9，4： | 2 |
| 3 | Bioactive chemicals and biological-biochemical acdvides and their function in rhizospheres of wetland plants 显示文摘 | Amir N | 2000 | The Botanical Review2000，66，3： | 1 |
| 4 | Effect of transcranial magnetic stimulation in posttraumatic stress disorder:a preliminary study显示文摘 | Grisaru N Amir M Cohen H | 1998 | Biol Psychiatry1998，，44： | 1 |
| 5 | Hypoxia-inducible factor(HIF) in human tumorigenesis显示文摘 | MABJEESH N J AMIR S | 2007 | Histal Histopathal2007，22，5： | 1 |
| 6 | Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea显示文摘 | Lorraine Kyne Michel Warny Amir Qamar Ciarán P Kelly | 2001 | 2001 (9251)2001，，9251： | 1 |
| 7 | Spinal nerve injuryenhances sub-threshold membrane potential oscillations in DRGneurons:relation to neuropathic pain显示文摘 | LIU C N MICHAELIS M AMIR R | 2000 | J Neurophysiol2000，84，： | 1 |
| 8 | Microfluidic positioning of pollen grains in lab-on-achip for single cell analysis显示文摘 | MAHMOOD G AMIR S N CARLOS G A | 2014 | Journal of Bioscience and Bioengineering2014，117，4： | 1 |
| 9 | Interpretation in social anxiety:When meaning precedes ambiguity显示文摘 | Beard C Amir N | 2009 | Cognitive Therapy and Research2009，33，4： | 1 |
| 10 | Analysis and comparison of some frequency compounding algorithms for the reduction of ultrasonic clutter显示文摘 | Amir I Bilgutay N M Newhouse V L | 1986 | IEEE Trans UFFC1986，33，4： | 1 |
| 11 | A sustainable integrated system for culture of fish,seaweed and abalone显示文摘 | Amir N Muki S Ezra D B | 2000 | Aquaculture2000，186，： | 1 |
| 12 | The relati- onship between cognitive control and post- traumatic stress symptoms 显示文摘 | Bomyea J Amir N Lang AJ | 2011 | J Behav Ther Exp Psychiatry2011，43，2012： | 1 |
| 13 | Implicit memory for negative and positive social information in individuals with and without social anxiety显示文摘 | Amir N Bower E Briks J | 2003 | Cognition&Emotion2003，17，4： | 1 |
| 14 | The effect of a sin- gle-session attention modification program on response to a public-speaking challenge in socially anxious individuals 显示文摘 | Amir N Weber G Beard C | 2008 | Journal of Abnormal Psychology2008，117，： | 1 |
| 15 | Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract 显示文摘 | Barman M Unold D Shifley K Amir E Hung K Bos N Salzman N | 2008 | Infect Immun2008，76，3： | 1 |
| 16 | Prospective study evaluatingthe impact of tissue confirmation of metastatic disease in patientswith breast cancer显示文摘 | Amir E Miller N Geddie W | 2012 | J Clin Oncol2012，30，6： | 1 |
| 17 | Malleability of attentional bias for positive emotional information and anxiety vulnerability 显示文摘 | Talor CT Bomyea J Amir N | 2011 | Emo- tion2011，11，1： | 1 |
| 18 | Photodegrada- tion and flow-injection determination of dithiocarbamate fungicides in natural water with chemiluminescence de- tection显示文摘 | Amir W Mohammad Y and Abdul N | 2009 | Anal Sci2009，25，： | 1 |
| 19 | Attention training in individuals with generalized social phobia:a randomized controlled trial显示文摘 | Amir N Beard C Taylor C T | 2009 | Journal of Consulting and Clinical Psychology2009，77，5： | 1 |
| 20 | Negative interpretation bias mediates the effect of social anxiety on state anxiety 显示文摘 | Beard C Amir N | 2010 | ?Cognitive thera- py and research2010，34，： | 1 |
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