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| 1 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 2 | Cyanidin 3-glucoside modulated cell cycle progression in liver precancerous lesion,in vivo study显示文摘BACKGROUND Cyanidin-3-O-glucoside(cyan)exhibits antioxidant and anticancer properties.The cell cycle proteins and antimitotic drugs might be promising therapeutic targets in hepatocellular carcinoma.AIM To investigate the effect of cyan administration on cell cycle in hepatic precancerous lesion(PCL)induced by diethylnitrosamine/2-acetylaminofluorene(DEN/2-AAF)in Wistar rats.METHODS In vivo,DEN/2-AAF-induced hepatic PCL,rats were treated with three doses of cyan(10,15,and 20 mg/kg/d,for four consecutive days per week for 16 wk).Blood and liver tissue samples were collected for measurement of the followings;alpha fetoprotein(AFP)liver function and RNA panel differential expression was evaluated via real time polymerase chain reaction.Histopathological examination of liver sections stained with H&E and immunohistochemical study using glutathione S-transferase placental(GSTP)and proliferating cell nuclear antigen(PCNA)antibodies were assessed.RESULTS Cyan administration mitigated the effect of DEN/2-AFF induced PCL,decreased AFP levels,and improved liver function.Remarkably,treatment with cyan dose dependently decreased the long non-coding RNA MALAT1 and tubulin gamma 1 mRNA expressions and increased the levels of miR-125b,all of which are involved in cell cycle and mitotic spindle assembly.Of note,cyan decreased GSTP foci percent area and PCNA positively stained nuclei.CONCLUSION Our results indicated that cyan could be used as a potential therapeutic agent to inhibit liver carcinogenesis in rat model via modulation of cell cycle. | Marwa Matboli Amany H Hasanin Reham Hussein Sarah El-Nakeep Eman K Habib Rawan Ellackany Lobna A Saleh | 2021 | World Journal of Gastroenterology2021，27，14： | 1 |
| 3 | Optimization of the Prodution of biosurfactant from Iranian indigeous bacteria for the reduction of surface tension and enhanced oil recovery显示文摘 | AMANI H HAGHIGHI M SARRAFZADEH M H | 2011 | Petroleum Science and Technology2011，29，3： | 1 |
| 4 | Solvent-free and selective oxidation of hydroxy groups to their corre-sponding carbonyl functions with ferric nitrate activated by heteropoly acids显示文摘 | Iranpoor N Amani K | 2003 | Synthesis2003，，3： | 1 |
| 5 | Use of Transcyte and dermabrasion to treat bums reduces length of stay in bums of all size and etiology显示文摘 | Amani H Dougherty WR Blome-Eberwein S | 2006 | Burns2006，32，7： | 1 |
| 6 | Optimiza- tion of the production of biosurfactant from Iranian indigenous bacteria for the reduction of surface tension and enhanced oil re- covery显示文摘 | AMANI H HAGHIGHI M SARRAFZADEH M H | 2011 | Petrol Sci Technol2011，29，30： | 1 |
| 7 | Utility of nanosized microemulsion for transdermal delivery of tolterodine tartrate: ex-vivo permeation and in-vivo pharmacokinetic studies 显示文摘 | Ahmed H Elshafeey Amany 0 Kameand Mohsen M Fathallah | 2009 | Pharm Res2009，26，11： | 1 |
| 8 | Solvent-Free and Selective Oxidation of Hydroxy Groups to their Corresponding Carbonyl Functions with Ferric Nitrate Activated by Heteropoly Acids 显示文摘 | Firouzabadi H Iranpoor N Amani K | 2003 | Synthesis2003，3，： | 1 |
| 9 | Prevalance of melasma in women in Ardabil city显示文摘 | Edalatkhah H Amani F Rezaifar G | 2004 | Iranian Journal of Dermatology2004，7，2： | 1 |
| 10 | Pre-treatment effect of different doses of soy isoflavones on spatial learning and memory in an ovariectomized animal model of Alzheimer's disease 显示文摘 | Sarkaki A Amani R Badavi M Moghaddam A Z Aligholi H Safahani M | 2008 | Pak J Biol Sei2008，11，： | 1 |
| 11 | A Survey on Mobile Data Offloading: Technical and Business Perspectives显示文摘 | A Aijaz H Aghvami M Amani | 2013 | IEEE Wireless Communications2013，20，2： | 1 |
| 12 | A survey on mobile data off- loading: technical and business perspeetives显示文摘 | Aijaz A Aghvami H Amani M | 2013 | IEEE Wireless Communications2013，20，2： | 1 |
| 13 | 显示文摘 | Fatma H ElBatal Amany Elkheshen | 2008 | Mater Chem Phys2008，110，： | 1 |
| 14 | Mixed discrete least squares meshless method for planar elasticity problems using regular and irregular nodal distributions显示文摘 | Amani J Afshar M H Naisipour M | | 0，，： | 1 |
| 15 | Pre-treatment effect of different doses of soy isoflavones on spatial learning and memory in an ovariectomized animal model of Alzheimer’s disease显示文摘 | Sarkaki A Amani R Badavi M Moghaddam AZ Aligholi H Safahani M Haghighizadeh MH | 2008 | Pak J Biol Sci2008，11，8： | 1 |
| 16 | HLA-DQB1 * 等位基因和基因危险性到类型 1 糖尿病 mellitus显示文摘 AIM: To determine human leukocyte antigen (HLA)DQB1 allele association with susceptibility to type 1 diabetes (T1D) and to clinical and laboratory findings. METHODS: This study was conducted on 85 unrelated Egyptian children with T1D recruited consecutively from the Pediatric Diabetes Endocrinology outpatients Clinic; Mansoura University Children’s Hospital, Egypt. Patient mean follow up period was 2.5 years. Patients were subdivided according to level of HbA1c (optimal/suboptimal control < 8.5% and poor control ≥ 8.5%). Thecontrol group consisted of 113 unrelated ageand sexmatched healthy subjects without T1D or other autoimmune diseases. Genomic DNA extraction was done for all subjects using a DNA isolation kit. HLA-Class Ⅱ-DQB1 allele typing was carried out with a polymerase chain reaction-sequence-specific oligonucleotide probe using a INNO-LiPA HLA-DQB1 update kit. RESULTS: Significant differences were detected between Egyptian patients with T1D and control groups in the frequencies of DQB1*02 [44.4% vs 18.6%, corrected P value (Pc) < 0.001] and DQB1*03 (41.2% vs 24.4%, Pc < 0.001). Significant differences were also observed between control groups and T1D patients in the frequencies of DQB1*05 (14.6% vs 7.2%, P = 0.029) and DQB1*06 (34.1% vs 7.2%, P < 0.001). However, after correction for multiple comparisons, the significance was retained for HLA-DQB1*06 (Pc < 0.001) but lost for HLA-DQB1*05. HLA-DQB1*0201, *0202, *030201 were positively associated with T1D (Pc = 0.014, Pc < 0.001, and Pc < 0.001 respectively), while HLA-DQB1*060101 was negatively associated (Pc < 0.001) with the condition. Although the HLA-DQB1 alleles 030101 and 050101 were significantly higher in controls (P = 0.016, P = 0.025 respectively), both of them lost statistical significance after correction of P value. The frequency of the HLA-DQB1 genotypes 02/02, 02/03, and 03/03 was higher in T1D patients, and the frequency of the genotypes 03/06, 05/06, and 06/06 was higher in controls, these differences being statistically significant before correction. After correction, the genotypes 02/02, 02/03 in T1D, and the genotypes 03/06, 06/06 in controls were still significant (Pc = 0.01, Pc < 0.001, Pc < 0.001, and Pc = 0.04, respectively). Non-significant associations were found between the frequency HLA-DQB1 alleles and genotypes in T1D in relation to the grade of diabetic control, Microalbuminuria, age, gender, age of presentation, weight, height, frequency of diabetic ketoacidosis (P =0.42), serum cholesterol, and fasting and post-prandial level of C-peptide (P = 0.83, P = 0.9, respectively). CONCLUSION: The Current work suggests that HLADQB1 alleles *030201, *0202, *0201, and genotypes 02/03, 02/02 may be susceptibility risk factors for development of T1D in Egyptian children, while the HLADQB1*060101 allele, and 03/06, 06/06 genotypes may be protective factors. HLA-DQB1 alleles and genotypes do not contribute to microalbuminuria or grade of diabetic control. | Youssef M Mosaad Fatma A Auf Shereen S Metwally Ashraf A Elsharkawy Amany K El-Hawary Rasha H Hassan Ziyad E Tawhid Farha A El-Chennawi | 2012 | World Journal of Diabetes2012，3，8： | 1 |
| 17 | Unusual phenolic glycosides from Cotoneastcrorbicularis显示文摘 | AMANI M D E SAHAR M H IRMGARD M | 2000 | Phytoehemistry2000，53，6： | 1 |
| 18 | Comparative study of bio-surfactant pro- ducing bacteria in MEOR application 显示文摘 | AMANI H SARRAFZADEN M H HAGHIGHI M | 2010 | J Petro Sci Eng2010，75，2： | 1 |
| 19 | UV-light Induced Photocatalytic Decolorization of Rhodamine 6G Molecules over BiOCl from Aqueous Solution 显示文摘 | Gondal M A Chang X F Amani Z H | 2010 | Chemical Engineering Journal2010，165，1： | 1 |
| 20 | Comparativestudy of biosurfactant producing bacteria in MEOR application显示文摘 | Amani H Sarrafzadeh M H Haghighi M | 2010 | J Petrol Sci Eng2010，75，12： | 1 |
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