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| 1 | Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia显示文摘AIM:To identify the distribution of hepatitis B virus (HBV) subgenotype and basal core promoter (BCP) mutations among patients with HBV-associated liver disease in Indonesia.METHODS: Patients with chronic hepatitis (CH, n=61), liver cirrhosis (LC, n=62), and hepatocellular carcinoma (HCC,n=48) were included in this study. HBV subgenotype was identified based on S or preS gene sequence, and mutations in the HBx gene including the overlapping BCP region were examined by direct sequencing.RESULTS: HBV genotype B (subgenotypes B2, B3, B4, B5 and B7) the major genotype in the samples, accounted for 75.4%, 71.0% and 75.0% of CH, LC and HCC patients, respectively, while the genotype C (subgenotypes C1, C2 and C3) was detected in 24.6%, 29.0%, and 25.0% of CH, LC, and HCC patients, respectively. Subgenotypes B3 (84.9%) and C1 (82.2%) were the main subgenotype in HBV genotype B and C, respectively. Serotype adw2 (84.9%) and adrq+ (89.4%) were the most prevalent in HBV genotype B and C, respectively. Double mutation (A1762T/G1764A) in the BCP was significantly higher in LC (59.7%) and HCC (54.2%) than in CH (19.7%), suggesting that this mutation was associated with severity of liver disease. The T1753V was also higher in LC (46.8%), but lower in HCC (22.9%) and CH (18.0%), suggesting that this mutation may be an indicator of cirrhosis.CONCLUSION: HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia. Mutations in BCP, such as A1762T/G1764A and T1753V, might have an association with manifestations of liver disease. | Andi Utama Sigit Purwantomo Marlinang Diarta Siburian Rama Dhenni Rino Alvani Gani Irsan Hasan Andri Sanityoso Upik Anderiani Miskad Fardah Akil Irawan Yusuf Wenny Astuti Achwan Soewignjo Soemohardjo Syafruddin AR Lelosutan Ruswhandi Martamala Benyamin Lukito Unggul Budihusodo Laurentius Adrianus Lesmana Ali Sulaiman Susan Tai | 2009 | World Journal of Gastroenterology2009，15，32： | 4 |
| 2 | Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients显示文摘AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients.METHODS:Sixty-four patients with chronic hepatitis,65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this study.HBeAg and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by sequencing.Viral load was measured by real-time polymerase chain reaction.RESULTS:Of 179 patients,108 (60.3%) were HBeAg(-) and 86 (79.6%) of these HBeAg(-) patients had been seroconverted.The A1896 mutation was not found in HBeAg(+) patients,however,this mutation was detected in 70.7% of HBeAg(-) patients.This mutation was frequently found when HBeAg was not expressed (87.7%),compared to that found in HBeAg seroconverted patients (65.1%).The A1899 mutation was also more prevalent in HBeAg(-) than in HBeAg(+) patients (P=0.004).The T1762/A1764 mutation was frequently found in both HBeAg(+) and HBeAg(-) patients,however,the prevalence of this mutation did not significantly differ among the two groups (P=0.054).In HBeAg(+) patients,the T1762/A1764 mutation was correlated with lower HBV DNA (P < 0.001).The A1899 mutation did not correlate with HBV DNA (P=0.609).In HBeAg(-) patients,the T1762/A1764 mutation alone was not correlated with HBV DNA (P=0.095),however,the presence of either the T1762/A1764 or A1896 mutations was associated with increased HBV DNA (P < 0.001).CONCLUSION:The percentage of HBeAg(-) patients is high in Indonesia,and most of the HBeAg(-) patients had been seroconverted.The A1896 mutation was most likely the major cause of HBeAg loss.The T1762/A1764 mutation alone was associated with lower viral loads in HBeAg(+) patients,but not in HBeAg(-) patients. | Andi Utama Marlinang Diarta Siburian Sigit Purwantomo Mariana Destila Bayu Intan Tri Shinta Kurniasih Susan Tai Rino Alvani Gani Laurentius Adrianus Lesmana All Sulaiman Wenny Astuti Achwan Soewignjo Soemohardjo Arnelis Nasrul Zubir Julius Syafruddin AR Lelosutan Benyamin Lukito Tantoro Harmono | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 3 | Synthesis and characterization of nanocrystalline MnFe204 : Ad- vances in thermochemicaI water splitting 显示文摘 | ALVANI C ENNAS G BARBERA L A | 2005 | Interna- tional Journal of Hydrogen Energy2005，30，： | 1 |
| 4 | Chemical equilibria involved in the oxygen-releasing step of manganese ferrite water-splitting thermochemical cycle 显示文摘 | SERALESSANDR L BELLUSCI M ALVANI A | 2008 | Journal of Solid Sate Chemistry2008，181，： | 1 |
| 5 | The synbioticeffects of konjac glucomannan hydrolysates (GMH) and lactobacilli onthe growth of Staphylococcus aureus and Salmonella typhimurium显示文摘 | AL-GHAZZEWI F H TESTER R F ALVANI K | 2012 | Nutrition & Food Science2012，42，2： | 1 |
| 6 | Lithium titanate pebbles reprocessing by wet chemistry 显示文摘 | ALVANI C CARCONI PL CASADIO S | 2001 | Journal of Nuclear Materials2001，289，3： | 1 |
| 7 | Physico-chemical properties of potato starches显示文摘 | Alvani K Qi X Tester R F | 2011 | Food Chemistry2011，125，3： | 1 |
| 8 | Kinet- ics of tritium release from irradiated Li2 TiO3 peb- bles in out-o{-pile TPD tests 显示文摘 | ALVANI C CASADIO S CASADIO S | 2003 | Fusion Eng Des2003，69，14： | 1 |
| 9 | Kinetics of tritium release from irradiated Li2TiO3 pebbles in out-of-pile TPD tests 显示文摘 | ALVANI C CASADIO S CASADIO S | 2003 | Fusion Eng Des2003，69，4： | 1 |
| 10 | Synthesis and characterization of Co 1-x Zn x Cr 2-y A1 y O 4 as a near- infrared reflective color tunable nano- pigment显示文摘 | HEDAYATI H R ALVANI A A S SAMEIE H | 2015 | Dyes and Pigments2015，，： | 1 |
| 11 | Preparation and properties of long afterglow in alkaline earth silicate phosphors co -doped by Eu2 O3 and Dy2 O3显示文摘 | Sabbagh Alvani A A Moztarzadeh F | 2005 | Journal of Luminescence2005，115，34： | 1 |
| 12 | Improvement of sintered density of Li2TiO3 pebbles fabricated by direct-wet process显示文摘 | TSUCHIYA K KAWAMURA H UCHIDA M CASADIO S ALVANI C ITO Y | | 0，，： | 1 |
| 13 | Effects of gelation and sintering conditions on granulations of Li2TiO3 pebbles from Li-Ti complex solution显示文摘 | TSUCHIYA K KAWAMURA H CASADIO S ALVANI C | | 0，，： | 1 |
| 14 | Synthesis and characterization of Co1-xZnxCr2-yAlyO4as a near-infrared reflective color tunable nano-pigment显示文摘 | Hedayati H R Alvani A A S Sameie H | 2015 | Dyes and Pigments2015，113，： | 1 |
| 15 | Gelatinisation properties of native and annealed potato starches显示文摘 | Alvani K Qi X Tester R F | 2012 | Starch/Starke2012，64，： | 1 |
| 16 | Amylolysis of native and annealed potato starches following progressive gelatinization显示文摘 | Alvani K Tester R F Lin C L | 2014 | Food Hydroeolloids2014，36，： | 1 |
| 17 | Synthesis and characterization of Co1-xZnxCr2-yAlyO4as a near-infrared reflective color tunable nano-pigment显示文摘 | Hedayati H R Alvani A A S Sameie H | 2015 | Dyes and Pigments2015，113，： | 1 |
| 18 | Preparation and properties of long dterglow in alkaline earth-silicate phosphors co-doped by Eu2O3 and Dy2O3显示文摘 | SABBA GH ALVANI A A MOZTARZADEH F SARABI A A | 2005 | J Lumin2005，115，： | 1 |
| 19 | A 100 year update on diagnosis of tuberculosis infection显示文摘 | alvani A Pareek M | 2010 | Br Med Bull2010，93，11： | 1 |
| 20 | Synthesis and characterization of Co1-xZnxCr2-yAlyO4 as a near-infrared reflective color tunable nano-pigment 显示文摘 | HEDAYATI H R ALVANI A A S SAMEIE H | 2015 | Dyes and Pigments2015，113，： | 1 |
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