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| 1 | Effects of glutamine and curcumin on bacterial translocation in jaundiced rats显示文摘AIM: To investigate the effect of curcumin on bacterial translocation and oxidative damage in an obstructive jaundice model and compare the results to glutamine, an agent known to be effective and clinically used. METHODS: Twenty-four female Wistar-Albino rats, weighing 200-250 g, were randomly divided into three groups (8 in each group). After ligation of the common bile duct in all animals, GroupⅠ received oral normal saline, Group Ⅱ received oral glutamine and Group Ⅲ received oral curcumin for seven days. Blood samples via cardiac puncture, tissue samples (terminal ileum, liver and mesenteric lymph node) and peritoneal fluid were obtained from the animals at the time of death to investigate bacterial translocation and oxidative damage. RESULTS: We observed that both glutamine and curcumin reduced bacterial translocation in blood, hepatocellular damage, plasma cytokine levels, oxidative tissue damage and apoptosis significantly compared to the control group. Additionally, glutamine showed protective effects on ileal epithelium and reduced villus atrophy. CONCLUSION: On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice. | Oguzhan Karatepe Ersin Acet Muharrem Battal Gokhan Adas Ahu Kemik Merih Altiok Gulcin Kamali Safiye Koculu Atahan Catay Sedat Kamali Servet Karahan | 2010 | World Journal of Gastroenterology2010，16，34： | 5 |
| 2 | The superior mesenteric artery syndrome in patients with spinal deformity显示文摘 | Altiok H Lubicky J P DeWald C J | 2005 | Spine (Phila Pa 1976)2005，30，19： | 1 |
| 3 | Phase I pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor MS-275 in combination with 13-cis-retinoic acid in patients wit advanced solid tumors显示文摘 | PILI R RUDEK M ALTIOK S | 2006 | J Clin Oncol2006，24，18： | 1 |
| 4 | Waiting time approximation in single-class queueing systems with multiple types of interrup- tions:modeling congestion at waterways entrances显示文摘 | Ozgecan S Ulusqu Tayfur Altiok | 2009 | Annals of Operations Research (ANOR)2009，172，1： | 1 |
| 5 | Panoramic radiographs:a tool for investigating skeletal pattern显示文摘 | Akcam MO Altiok T Ozdiler E | 2003 | Am J Orthod Dentofacial Orthop2003，123，2： | 1 |
| 6 | The superior mesenteric artery syndrome in patients with spinal deformity显示文摘 | ALTIOK H LUBIEKY J P DEWALD C J | 2005 | Spine2005，30，19： | 1 |
| 7 | Strain rate measurement by doppler echocardiography allows improved assessment of myocardial viability inpatients with depressed left ventricular function显示文摘 | Hoffmann R Altiok E Nowak B | 2002 | J Am Coll Cardiol2002，39，3： | 1 |
| 8 | Quantitative analysis ofendocardial and epicardial left ventricular myocardial deformation-compmson of strain-encoded cardiac magnetic resonance imagingwith two-dimensional speckle-tracking echocardiography 显示文摘 | Altiok E Neizel M Tiemann S | 2012 | J AmSoc Echocardiogr2012，25，11： | 1 |
| 9 | Simvastatin induces apoptosis in human breast cancer cells:p53 and estrogen receptor independent pathway requiring signalling through JNK显示文摘 | Koyuturk M Ersoz M Altiok N | | 0，，01： | 1 |
| 10 | Strain rate measurement by doppler echocardiography allows improved assessment of myocardial viability inpatients with depressed left ventricular function显示文摘 | Altiok E Nowak B | 2002 | J Am Coll Cardiol2002，39，3： | 1 |
| 11 | Ginkgo biloba extract regulates differentially the cell death induced by hydrogen peroxide and simvastatin显示文摘 | Altiok N Ersoz M Karpuz V | 2006 | Neurotoxicology2006，27，2： | 1 |
| 12 | Application of multi-dimensional procurement auction in?single-period inventory models显示文摘 | Pooya Farahvash Tayfur Altiok | 2008 | Annals of Operations Research2008，，1： | 1 |
| 13 | Myocardial deformation imaging by two-dimensional speckle-tracking echoeardiography for prediction of global and segmental functional changes after acute myocardial infarction : a comparison with late gadolinium enhance- ment cardiac magnetic resonance 显示文摘 | Altiok E Tiemann S Becker M | 2014 | Journal of the American Society of Echocardiography Official Publication of the American Society of Echocardiography2014，27，3： | 1 |
| 14 | Myocardial deformation imaging by two-dimensinnal speekle-tracking eehoeardiography for prediction of global and segmental functional changes 'after acute myoeardial infaretion: a comparison with late gadolinium enhance- ment eardiac magnetic resonance 显示文摘 | Altiok E Tiemann S Becket' M | 2014 | J Am Soe Echoeardiogr2014，27，3： | 1 |
| 15 | Simulation modeling of the vessel traffic in delaware river:Impact of deepening on portperformance显示文摘 | Ozhan Alper Almaz Tayfur Altiok | 2012 | Simulation Modelling Practice and Theory2012，22，3： | 1 |
| 16 | Strain rate measurement by doppler echocardiography allows improved assessment of myocardial viability inpatients with depressed left ventricular function显示文摘 | Altiok E Nowak B | 2002 | J Am Cell Cardiol2002，39，3： | 1 |
| 17 | Strain rate measurement by Doppler echocardiog raphy allows improved assessment of myocardial viability in patients with depressed left ventricular function显示文摘 | Hoffmann R Altiok E Nowak B | 2002 | J Am Coll Cardiol2002，39，3： | 1 |
| 18 | Approximation analysis of queues in series with phase-type server time and blocking显示文摘 | Altiok T | 1989 | Opns Res1989，，37： | 1 |
| 19 | Strain rate measurement by Doppler eehoeardiography allows improved assessment of myocardial viability in patients with depressed left ventricular function 显示文摘 | Hoffmann R Altiok E Nowak B | 2002 | J Am Coll Cardiol2002，39，： | 1 |
| 20 | PPARγ induce cell cycle withdrawal:inhibition of E2F/DP DNA-bunding activity via downregulation of PP2A显示文摘 | Altiok s Xu M Spiegelman BM | 1997 | Geres Dev1997，11，： | 1 |
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