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| 1 | A preliminary study of neck-stomach syndrome显示文摘AIM: To determine the expression of c-Fos, caspase-3 and interleukin-1β (IL-1β) in the cervical cord and stomach of rats with cervical spondylosis, to analyze their relationship, and to offer an explanation of one possible cause for functional dyspepsia (FD) and irritable bowel syndrome (IBS) caused by cervical spondylosis. METHODS: The cervical spondylosis model in rats was established by destroying the stability of cervical posterior column. The cord segments C4-6 and gastric antrum were collected 3 mo and 5 mo after the operation. Rats with the sham operation were used as controls. The expressions of c-Fos, caspase-3 and IL-1β in the cervical cord and gastric antrum were determined by immunohistochemistry and/or Western blot. RESULTS: Immunohistochemical staining showed a few c-Fos, caspase-3 and IL-1β-positive cells in the cervical cord and antrum in the control. There was a significant increase in c-Fos, caspase-3 and IL-1β expression in model groups compared to the control groups at 3 mo and 5 mo after operation. More importantly, there was a significant (P < 0.05) increase in c-Fos, caspase-3 and IL-1β expression in the model group rats at 3 mo compared to those at 5 mo after the operation (c-Fos: 11.20 ± 2.26 vs 27.68 ± 4.36 in the cervical cord, 11.3 ± 2.3 vs 29.3 ± 4.6 in the gastric antrum; caspase-3: 33.83 ± 3.71 vs 36.32 ± 4.01 in the cervical cord, 13.23 ± 3.21 vs 26.32 ± 4.01 in the gastric antrum; IL-1β: 42.06 ± 2.95 vs 45.91 ± 3.98 in the cervical cord, 26.56 ± 2.65 vs 32.01 ± 2.98 in the gastric antrum). Western blotanalysis showed time-dependent changes of caspase-3 and IL-1β protein in the cervical cord and gastric antrum of rats with cervical spondylosis; there was no significant expression of caspase-3 and IL-1β protein in the control group at 3 mo and 5 mo after the sham operation, whereas there was a significant difference in caspase-3 and IL-1β protein levels between the model group rats followed up for 3 mo and those for 5 mo (P < 0.05). CONCLUSION: There is a significant association of c-Fos, caspase-3 and IL-1β expressions in the gastric antrum with that in the spinal cord in rats with cervical spondylosis, suggesting that the gastrointestinal function may be affected by cervical spondylosis. | Xing-Hua Song Xiao-Xiong Xu Li-Wen Ding Li Cao Alken Sadel Hao Wen | 2007 | World Journal of Gastroenterology2007，13，18： | 2 |
| 2 | Shock wave lithotripsy versus ureteroscopy for distal ureteral calculi: a prospective study显示文摘 | P. Honeck A. H?cker P. Alken M. S. Michel T. Knoll | 2006 | Urological Research2006，，3： | 2 |
| 3 | MMPI correlates of sleep and respiratory disturbance in obstructive sleep apnea显示文摘 | Alkens | 1999 | Sleep1999，22，3： | 1 |
| 4 | Local RNA taget structure influences siRNA efficacy:a systematic global analysis显示文摘 | Overhoff M Alken M Far R K | 2005 | J Mol Biol2005，348，4： | 1 |
| 5 | Clinical value of percutaneous nephrolithotomy显示文摘 | Knoll T Wendt-Nordahl G Alken P | | 0，，03： | 1 |
| 6 | Local RNA Target Structure Influences siRNA Efficacy:A Systematic Global Analysis显示文摘 | OVERHOFF M ALKEN M FAR R K | | 0，，04： | 1 |
| 7 | Molecular weight,polydispersity,and spectroscopic properties of aquatic humic substances显示文摘 | Chin Y P Alken G O' Loughlin E | | 0，，： | 1 |
| 8 | Guidelines on urolithiasis 显示文摘 | TISELIUS HG ACKERMANN D ALKEN P | 2001 | Eur Urol2001，40，4： | 1 |
| 9 | Aluminium rolling mills of Europe 显示文摘 | Alken | 2005 | Aluminium Times2005，，： | 1 |
| 10 | Guidelines onurolithiasis显示文摘 | Tiselius HG Ackermann D Alken P | 2001 | Eur Urol2001，40，4： | 1 |
| 11 | Shock wave lithotripsy versus ureterescopy for distal ureteral calculi:a prospective study显示文摘 | Honeck P Hacker A Alken P | 2006 | Urol Res2006，34，3： | 1 |
| 12 | hypericum extract LI160 and fiuoxetine in mild to moderate depression: a random- ized, placebo-controlled multicenter study in outpatients显示文摘 | Bjerkenstedt L Edman GV Alken RG | 2005 | Eur Arch Psychiatry Clin Neurosci2005，255，1： | 1 |
| 13 | Guidelines on urolithiasis 显示文摘 | Tiselius HG Ackemmnn D Alken P | 2001 | Eur Urol2001，40，4： | 1 |
| 14 | Guidelines on urolithiasis显示文摘 | Tiselius HG Ackermann D Alken P | 2001 | Eur Urol2001，40，4： | 1 |
| 15 | Clinical value of percutaneous nephrolithotomy显示文摘 | Knoll T Wendt-Nordahl G Alken P | 2005 | Urology2005，44，3： | 1 |
| 16 | Guidelines on urolithiasis显示文摘 | Tiselius H G Ackermann D Alken P | 2001 | Eur Urol2001，40，4： | 1 |
| 17 | Guidelines on urolithia- sis显示文摘 | Tiselius H G Ackermann D Alken P | 2001 | Eur Urol2001，40，4： | 1 |
| 18 | Local RNtarget tructure influences siRNA efficacy: A systematic globanalysis 显示文摘 | Overhoff M Alken M Far RK | 2005 | J Mol Biol2005，348，4： | 1 |
| 19 | Guidelines on urolithiasis显示文摘 | Tiselius HG1 Ackermann D Alken P | 2001 | Eur Urol2001，40，4： | 1 |
| 20 | Guidelines on urolithiasis显示文摘 | Tiselius H G Ackermann D Alken P | 2001 | Eur Urol2001，40，4： | 1 |
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