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| 1 | Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer显示文摘AIM To study tumor response, and tolerability of arterially directed embolic therapy(ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases(CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients.METHODS Patients were included in the study if they were affected by CRC-LM, refractory to systemic chemotherapy, treated with ADET using polyethylene glycol embolics, and had liver involvement < 50%. Tumor response, performance status(PS), tumor marker antigens, and quality of life(QoL) were monitored at 1, 3 and 6 mo after ADET. QoL was assessed with the Palliative Performance Scale(PPS).RESULTS We treated 50 consecutive CRC-LM patients with ADET using polyethylene glycol embolics. Their tumor response one month after ADET was: 28% of complete response(CR), 48% of partial response(PR), 8% stable disease(SD), and 16% of progression. Tumor response 3 mo after ADET was CR 24%, PR 38%, SD 19% and progression disease(PD) 19%. Tumor response 6 mo after ADET was CR 18%, PR 44%, SD 21% and PD 18%. QoL was 90% PPS at each time point. Median time to progression for patients who progressed was 2.5 mo(range 0.8-6). Median follow-up was 14 mo(0.8-25 range). ADETs were performed with no complications. Observed side effects(mild or moderate intensity) were: Pain in 32% of patients, increase of transaminase levels in 20% and fever in 14%, whereas 30% of patients did not complain any adverse event. CONCLUSION The treatment of unresectable CRC-LM with ADET using polyethylene glycol microspheres loaded with irinotecan was effective in tumor response and resulted in mild toxicity, and good QoL. | Giammaria Fiorentini Riccardo Carandina Donatella Sarti Michele Nardella Odysseas Zoras Stefano Guadagni Riccardo Inchingolo Massimiliano Nestola Alessandro Felicioli Daniel Barnes Navarro Fernando Munoz Gomez Camillo Aliberti | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 6 |
| 2 | Multidisciplinary approach of colorectal cancer liver metastases显示文摘Large bowel cancer is a worldwide public health challenge.More than one third of patients present an advanced stage of disease at diagnosis and the liver is the most common site of metastases.Selection criteria for early diagnosis,chemotherapy and surgery have been recently expanded.The definition of resectability remains unclear.The presence of metastases is the most significant prognostic factor.For this reason the surgical resection of hepatic metastases is the leading treatment.The most appropriate resection approach remains to be defined.The two step and simultaneous resection processes of both primary and metastases have comparable survival long-term outcomes.The advent of targeted biological chemotherapeutic agents and the development of loco-regional therapies(chemoembolization,thermal ablation,arterial infusion chemotherapy) contribute to extend favorable results.Standardized evidence-based protocols are missing,hence optimal management of hepatic metastases should be single patient tailored and decided by a multidisciplinary team.This article reviews the outcomes of resection,systemic and loco-regional therapies of liver metastases originating from large bowel cancer. | Giammaria Fiorentini Donatella Sarti Camillo Aliberti Riccardo Carandina Andrea Mambrini Stefano Guadagni | 2017 | World Journal of Clinical Oncology2017，8，3： | 4 |
| 3 | Effectiveness and safety of oxaliplatin compared to cisplatin for advanced, unresectable gastric cancer: a systematic review and meta-analysis显示文摘 | Francesco Montagnani Gina Turrisi Claudio Marinozzi Camillo Aliberti Giammaria Fiorentini | 2011 | Gastric Cancer2011，，1： | 2 |
| 4 | Chlamydia pneumoniae and Mycoplasma pneumoniae显示文摘 | Tarsia P Aliberti S | 2005 | Semin Respir Crit Care Med2005，26，6： | 1 |
| 5 | Incidence, etiology, timing, and risk factors for clinical failure in hospitalized patients with community-acquired pneumonia 显示文摘 | Aliberti S Arnir A Peyrani P | 2008 | Chest2008，134，5： | 1 |
| 6 | Clinical stability versus clinical failure in pa- tients with community acquired pneumonia显示文摘 | Aliberti S Blasi F | 2012 | Semin Respir Crit Care Med2012，33，3： | 1 |
| 7 | Paediatricspinal Langerhans cell histiocytosis requiring corpectomy and fusion at C7 and at Th8-Th9 levels 显示文摘 | Talamonti G D'Aliberti GA Debernardi A | 2012 | BMJ Case Rep2012，，： | 1 |
| 8 | The role of lung ultrasound in the diagnosis and follow-up of communityacquired pneumonia显示文摘 | Reissig A Gramegna A Aliberti S | | 0，，： | 1 |
| 9 | Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite induced IL-12 production by dendritic cells显示文摘 | Scanga CA Aliberti J Jankovic D | 2002 | J Immunol2002，168，12： | 1 |
| 10 | Surgery for intracerebral hemorrhage显示文摘 | Collice M D'Aliberti G Talamonti G | 2004 | Neurol Sci2004，25，： | 1 |
| 11 | Positive and negative regulation of pathogen induced dendritic cell function by G-protein coupled receptors显示文摘 | Aliberti J Sher A | 2002 | Mol Immunol2002，38，1213： | 1 |
| 12 | Antibiotics as immunomodulant agents in COPD显示文摘 | Blasi F Mantero M Aliberti S | 2012 | Curr Opin Pharmacol2012，12，3： | 1 |
| 13 | The changing microbiologic epidemiology of community-acquired pneumonia 显示文摘 | Aliberti S Kaye KS | 2013 | Postgrad Med2013，125，6： | 1 |
| 14 | Analysis of fractalkine receptor CX3CR1 function by targeted deletionand green fluorescent protein reporter gene insertion 显示文摘 | Jung S Aliberti J Graemmel P | 2000 | Mol Cell Biol2000，20，11： | 1 |
| 15 | Incidence, etiology, timing, and risk factors for clinical failure in hospitalized patients with com- munity-acquired pneumonia显示文摘 | Aliberti S Amir A Peyrani P | 2008 | Chest2008，134，： | 1 |
| 16 | The management of community-acquired pneumonia in the elderly显示文摘 | Faverio P Aliberti S Bellelli G | 2014 | Eur J Intern Med2014，25，4： | 1 |
| 17 | Direct detection laser vibrometry with an amplitude modulated ladar 显示文摘 | Brian C Redman William C Ruff Keith Aliberti | 2004 | SPIE2004，5412，： | 1 |
| 18 | Surger for intracerebral hemorrhag显示文摘 | Collice M D Aliberti G Talamonti G | 2004 | Neurol Sci2004，25，： | 1 |
| 19 | Chlamydia pneumoniae and mycoplasma pneumoniae显示文摘 | Blasi F Tarsia P Aliberti S | 2005 | Semin Respir Crit Med2005，26，6： | 1 |
| 20 | Chlamydophila pneumoniae显示文摘 | Blasi F Tarsia P Aliberti S | 2009 | Clin Microbiol Infect2009，15，： | 1 |
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