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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study显示文摘Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April 2012.Data were extracted from hospital case files.Preoperative data included clinical presentation,routine investigations and liver function tests.Operative data included excessive adhesions,bleeding,bile leak,and drain insertion.Complicated cases such as pericholecystic collections,mucocele and empyema were also reported.Patients who needed therapeutic drainage were excluded.Postoperative data included hospital stay,volume of drained fluid,time of drain removal,and drain site problems.The study included 103 patients allocated into two groups;group A(n = 38) for patients with operative drain insertion and group B(n = 65) for patients without drain insertion.The number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B(80%) than group A(36.8%)(P < 0.001).Operative time was significantly longer in group A.All patients who were converted from laparoscopic to open cholecystectomy were in group A.Multivariate analysis revealed that hospital stay was significantly(P < 0.001) longer in patients with preoperative complications.There was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases. | Mohammed A Bawahab Walid M Abd El Maksoud Saeed A Alsareii Fahad S Al Amri Hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz | 2014 | The Journal of Biomedical Research2014，28，3： | 3 |
| 3 | H^+,N^+和Ar^+离子束辐射诱导碳纳米结构的变化(英文)显示文摘在室温和高温下,以不同辐射剂量的H+、N+和Ar+离子辐照多壁碳纳米管和无定形碳纳米线。利用透射电镜和拉曼光谱研究多壁碳纳米管和无定形碳纳米线的结构变化及损伤。以70keV N+离子束辐射多壁碳纳米管在室温下可形成无定形碳纳米线。1000K下70keV的H+离子束照射导致无定形碳纳米线向金刚石结构转变。离子辐照多壁碳纳米管的有序程度足够高,70keV的N+和Ar+离子能够引起碳从多壁碳纳米管的剥落。离子辐射能够为缺陷的转化提供必需的动力学驱动力。 | A Ishaq Shahid Iqbal Naveed Ali A A Khurram A U Akrajas C F Dee Shahzad Naseem H M Rafique Yan Long | 2013 | 新型炭材料2013，28，2： | 2 |
| 4 | Assessment of genetic diversity and relationship among a collection of US sweet sorghum germplasm by SSR markers显示文摘 | Ali M L Rajewski J F Baenziger P S | 2008 | Mol Breeding2008，21，： | 1 |
| 5 | Thermostable xylanase10B from Clostridium acetobutylicum ATCC824 显示文摘 | Ali M K Rudolph F B Bennett G N | 2004 | J Industrial Microbiol Biotechnol2004，，： | 1 |
| 6 | Experimental and numerical investigation on the behavior of transverse limited micro-grooves in EHL point contacts显示文摘 | Ali F Kaneta M K~upka I | 2015 | Tribology International2015，84，： | 1 |
| 7 | Use of X - ray diffraction in assessing the aging pattern of asphalt fractions 显示文摘 | SIDDIQUI M N ALI M F SHIROKOFF J | 2002 | Fuel2002，81，1： | 1 |
| 8 | Photophysics and dynamics of coumarin laser dyes and their analytical implications显示文摘 | M S A Abdel-Mottaleb M S Antonious M M Abo Ali L F M Ismail B A El-Sayed A M K Sherief | 1992 | Proceedings of the Indian Academy of Sciences - Chemical Sciences1992，，2： | 1 |
| 9 | Therapeutic potential of vasopressin receptor antagonists显示文摘 | Ali F Guglin M Vaitkevicius P | | 0，，06： | 1 |
| 10 | Reducing the friction of lubricated nonconformal point contacts by transverse shallow micro- grooves显示文摘 | Ali F K~upka I Hartl M | 2014 | Engineering Tribology2014，，： | 1 |
| 11 | Deep desulphurization of gasoline and diesel fuels using non--hydrogen consuming techniques显示文摘 | Ali M F A1-Malki A El-AliB | 2006 | Fuel2006，85，1011： | 1 |
| 12 | Synthesis and Sorption Behaviour of Some Radioactive Nuclides on Sodium Titanate as Cation Exchanger Adsorption显示文摘 | El-Naggar I M Mowafy E A Ali I M Aly H F | 2002 | Adsorption--Journal of the International Adsorption Society2002，8，： | 1 |
| 13 | Effects of a smaller unit cell planar EBG structure on the mutual coupling of a printed dipole array显示文摘 | M F Abedin M Ali | | 0，，： | 1 |
| 14 | Role of nitrosative and oxidative stress in neuropathy in patients with type 2 diabetes mellitus显示文摘 | Al-Nimer M S Al-Ani F S Ali F S | | 0，，01： | 1 |
| 15 | Effect of Hemin on BrainAlterations and Neuroglobin Expression in Water ImmersionRestraint Stressed Rats 显示文摘 | RAGY M ALI F RAMZY MM | 2016 | Scientifica (Cairo)2016，2016，78： | 1 |
| 16 | Impalpable testis: value of one-stage surgical descent 显示文摘 | Ait Ali Slimane M Auber F De Vries P | 2004 | Prog Urol2004，14，： | 1 |
| 17 | Deep desulp Hurzation of gasoline and diesel fuels using non-hydrogen consuming techniques显示文摘 | ALI M F MALKI A A ALI B E | 2006 | Fuel2006，85，1011： | 1 |
| 18 | Fabrication of Mo/Cu multilayer and bilayer transition edge sensors 显示文摘 | Ali Z A Drury O B Cunningham M F | 2005 | IEEE Transactions on Applied Superconductivity2005，15，2： | 1 |
| 19 | Current Steamflood Technology显示文摘 | Faroq Ali S M M Meldau R F | | 0，，10： | 1 |
| 20 | Inter - arterial third - generation recombinant tissue plasminogen activator (reteplase) for acute ischemicstroke显示文摘 | Qureshi Al Ali Z Suri M F K | 2001 | Neurosurgery2001，49，1： | 1 |
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