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| 1 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | Modeling the size distribution of a soil aerosol produced by sandblasting显示文摘 | Gaudichet A Gomes L | 1997 | Journal of Geophysical Research1997，102，11： | 1 |
| 3 | FDI, Productivity and Financial Development 显示文摘 | Alfaro L Chanda A Kalemli-Ozcan S Sayek S | 2009 | The World Economy2009，，32： | 1 |
| 4 | Mineral aerosol production by wind erosion:aerosol particle size and binding energies 显示文摘 | Gaudichet A Gomes L | 1998 | Geophysical Research Letters1998，25，7： | 1 |
| 5 | Mating disruption of California red scale, Aonidiella aurantii Maskell (Homoptera: Diaspididae), using biodegradable mesoporous pheromone dispensers 显示文摘 | VACAS S ALFARO C NAVARRO-LLOPIS V l | 2010 | Pest Managament Science2010，66，7： | 1 |
| 6 | FDI and economic growth: the role of local financial markets 显示文摘 | Alfaro L Chanda A Kalemli-Ozcan S | 2004 | Journal of In- ternational Economics2004，64，1： | 1 |
| 7 | Modeling the size distribution of a soil aerosol produced by sandblasting显示文摘 | Alfaro S C Gaudichet A Gomes L | 1997 | Journal of GeophysicalResearch1997，102，11： | 1 |
| 8 | Mineral aerosol production by wind erosion: aerosol particle size and binding energies显示文摘 | Alfaro S C Gaudichet A Gomes L | 1998 | Geophysal Research Letters1998，25，7： | 1 |
| 9 | Identification of trophic interactions within an estuarine food web(northern New Zealand) using fatty acid biomarkers and stable isotopes 显示文摘 | Alfaro A C Thomas F Sergent L | 2006 | Estuarine Coastal and Shelf Science2006，70，： | 1 |
| 10 | Validation of a dust production model from measurements performed in semi - arid agriculture areas of Spain and Niger显示文摘 | Gomes L Raj ot J L Alfaro S C | 2003 | Catena2003，52，2003： | 1 |
| 11 | Mineral aerosol production by wind erosion: Aerosol particle sizes and binding energies显示文摘 | Alfaro S C A Gaudichet L Gomes | 1998 | Geophysical Research Letters1998，25，7： | 1 |
| 12 | Identification of trophic interactions within an estuarine food web (northern New Zealand) using fatty acid biomarkers and stable isotopes 显示文摘 | Alfaro A C Thomas F Sergent L | 2006 | Estuarine Coastal and Shelf Science2006，70，： | 1 |
| 13 | Soil crusting on sandy soils and its influence on wind erosion显示文摘 | Rajot J L Alfaro S C Gomes L | 2003 | Catena2003，53，2003： | 1 |
| 14 | Validation of a dust production model from measurements performed in semi-arid agriculture areas of Spain and Niger 显示文摘 | Rajot J L Alfaro S C | | CATENA0，，： | 1 |
| 15 | Mineral Aerosol Production by Wind Erosion:Aerosol Particle Sizes and Binding Energies显示文摘 | ALFARO S C GAUDICHET A GOMES L | 1998 | Geophysical Research Letters1998，25，7： | 1 |
| 16 | FDI and e- conomic growth : the role of local finance market 显示文摘 | ALFARO L CHANDA A KALEMLI OZCAN S | 2004 | Journal of In- ternational Economics2004，，64： | 1 |
| 17 | Soil crusting on sandy soils and its influence on wind erosion 显示文摘 | Alfaro S C Gomes L | | CATENA0，，： | 1 |
| 18 | Size resolved dust emission fluxes measured in Niger during 3 dust storms of the AMMA experiment显示文摘 | Sow M ALFARO S C RAJOT J L | 2009 | Atmospheric Chemistry and Physics2009，9，12： | 1 |
| 19 | Platelet autoantibodies in patients with chronic liver disease显示文摘 | Pereira J Accatino L Alfaro J | 1995 | Am J Hematol1995，50，： | 1 |
| 20 | FDI and Econom- ic Growth: The Role of Local Financial Market显示文摘 | Alfaro L Chanda A Kalemli - Ozcan S | 2004 | Journal of In- ternational Economics2004，64，： | 1 |
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