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| 1 | Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats显示文摘AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion. | Carlos Rodrigo Cámara Francisco Javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
| 2 | Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods显示文摘The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/institutions.With an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science communities.From this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label reliability.To address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat heads.We now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version. | Etienne David Mario Serouart Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo | 2021 | Plant Phenomics2021，3，1： | 2 |
| 3 | Smoothelin,a new marker to determine the origin of liver fibrogenic cells显示文摘AIM:To explore this hypothesis that smooth muscle cells may be capable of acquiring a myofibroblastic phenotype,we have studied the expression of smoothelin in fibrotic conditions.METHODS:Normal liver tissue(n=3)was obtained from macroscopically normal parts of hepatectomy,taken at a distance from hemangiomas.Pathological specimens included post-burn cutaneous hypertrophic scars(n=3),fibrotic liver tissue(n=5),cirrhotic tissue(viral and alcoholic hepatitis)(n=5),and hepatocellular carcinomas(n=5).Tissue samples were fixed in 10%formalin and embedded in paraffin for immunohistochemistry or were immediately frozen in liquid nitrogen-cooled isopentane for confocal microscopy analysis.Sections were stained with antibodies against smoothelin,which is expressed exclusively by smooth muscle cells,andα-smooth muscle actin,which is expressed by both smooth muscle cells and myofibroblasts.RESULTS:In hypertrophic scars,α-smooth muscle actin was detected in vascular smooth muscle cells and in numerous myofibroblasts present in and around nodules,whereas smoothelin was exclusively expressed in vascular smooth muscle cells.In the normal liver,vascular smooth muscle cells were the only cells that expressα-smooth muscle actin and smoothelin.In fibrotic areas of the liver,myofibroblasts expressingα-smooth muscle actin were detected.Myofibroblasts co-expressingα-smooth muscle actin and smoothelin were observed,and their number was slightly increased in parallel with the degree of fibrosis(absent in liver with mild or moderate fibrosis;5%to 10%positive in liver showing severe fibrosis).In cirrhotic septa,numerous myofibroblasts co-expressedα-smooth muscle actin and smoothelin(more than 50%).In hepatocellular carcinomas,the same pattern of expression forα-smooth muscle actin and smoothelin was observed in the stroma reaction surrounding the tumor and around tumoral cell plates.In all pathological liver samples,α-smooth muscle actin and smoothelin were co-expressed in vascular smooth muscle cells.CONCLUSION:During development of advanced liver fibrosis,a subpopulation of myofibroblasts expressing smoothelin may be derived from vascular smooth muscle cells,illustrating the different cellular origins of myofibroblasts. | Sébastien Lepreux Christelle Guyot Fabrice Billet Chantal Combe Charles Balabaud Paulette Bioulac-Sage Alexis Desmoulière | 2013 | World Journal of Gastroenterology2013，19，48： | 2 |
| 4 | Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons显示文摘 | Alexis M S Thiruma V A Roy G C | 2008 | Nat Neurosci2008，11，： | 1 |
| 5 | Magnesium and its alloys as orthopedic biomaterials: A review 显示文摘 | MARK P S ALEXIS M P JERAWALA H | 2006 | Biomaterials2006，27，9： | 1 |
| 6 | Clinical appli cation of magnetic drug targeting显示文摘 | Lubbe A S Alexiou C Bergemann C | 2001 | Journal of Surgical Research2001，95，2： | 1 |
| 7 | Management of meningiomas显示文摘 | Alexiou GA Gogou P Markoula S | 2010 | Clin Neurol Neurosurg2010，112，3： | 1 |
| 8 | Effect of density on growth rate and production of rainbow trout (Salmo gairdneri) over a full rearing period显示文摘 | Papoutsoglou S E Papaparaskeva-Papoutsoglou E Alexis M N | 1987 | Aquac1987，66，： | 1 |
| 9 | Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the International Study Group of Rectal Cancer显示文摘 | Nuh N. Rahbari Jürgen Weitz Werner Hohenberger Richard J. Heald Brendan Moran Alexis Ulrich Torbj?rn Holm W. Douglas Wong Emmanuel Tiret Yoshihiro Moriya S?ren Laurberg Marcel den Dulk Cornelis van de Velde Markus W. Büchler | 2010 | Surgery2010，，3： | 1 |
| 10 | Management of meningiomas 显示文摘 | ALEXIOU G A GOGOU P MARKOULA S | 2010 | Clin Neurol Neurosurg2010，112，3： | 1 |
| 11 | Investigation to determine digestibility coefficients of various raw materials in diets for gilthead sea bream, Sparus auratns L显示文摘 | Nengas I Alexis M N Davies S J | 1995 | Aquaculture Research1995，26，： | 1 |
| 12 | Transplantanted adult hematopoietic stem cells differentiate into functional endothelial cells显示文摘 | Alexis S Bailey Shuguang Jiang Christina I | 2004 | Blood2004，103，： | 1 |
| 13 | Saline preferendum for the European sea bass, Dicentrarchus labrax, larvae and juveniles: effect of salinity on early development and sex determination 显示文摘 | ERIC S ALEXIS F PIERRICK H | 2003 | Journal of Experimental Marine Biology and Ecology2003，287，1： | 1 |
| 14 | Clinical applications of magnetic drug targeting显示文摘 | LUBBE A S ALEXIOU C BERGEMANN C | 2001 | J Surg Res2001，95，2： | 1 |
| 15 | Management of meningiomas显示文摘 | Alexiou GA Gogou P Markoula S | 2010 | Clin Neurol Neurosurg2010，112，3： | 1 |
| 16 | Long-distance pollen flow assessment through evaluation of pollinator forag- ing range suggests transgene escape distances 显示文摘 | RE'MY S P Alexis P Matthew B H | 2008 | Proceedings of the National Academy of Sciences of the United States of America2008，105，13： | 1 |
| 17 | Management of men- ingiomas 显示文摘 | Alexiou GA Gogou P Markoula S | 2010 | C lin Neurol Neurosurg2010，112，： | 1 |
| 18 | Clinical applications of magnetic drug targeting 显示文摘 | Ltibbe A S ALEXIOU C BERGEMANN C | 2001 | Journal of Surgical Research2001，95，2： | 1 |
| 19 | Fast and Accurate Link Prediction in Social Network Systems显示文摘 | Alexis P Panagiotis S Yannis M | 2012 | The Journal of Systems and Software2012，85，： | 1 |
| 20 | Tracking of oocyte dysmorphism for ICSI patients may prove relevant to the outcome in subsequent patient cycles 显示文摘 | Meriano JS Alexis J Visram-Zaver S | 2001 | Hum Reprod2001，16，： | 1 |
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