|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | The Global boundary Stratotype Section and Point (GSSP) of the Ladinian Stage (Middle Triassic) at Bagolino (Southern Alps, Northern Italy) and its implications for the Triassic time scale显示文摘 | Peter Brack Hans Riebe Alda Nicora Roland Mundil | 2005 | Episodes2005，28，4： | 15 |
| 3 | Hepatitis C virus infection and type 1 and type 2 diabetes mellitus显示文摘Hepatitis C virus(HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus(T1DM) and T2 DM. T2 DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1 DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2 DM and chronic hepatitis C(CHC) infection. The processes through which CHC is associated with T2 DM seem to involve direct viral effects, insulin resistance, proinflammatory cytokines, chemokines, and other immunemediated mechanisms. Few data have been reported on the association of CHC and T1 DM and reports on the potential association between T1 DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoim-munity and in certain cases lead to the development of T1 DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with nondiabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effec-tive programmes for the surveillance and treatment of diabetic CHC patients. | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Andrea Di Domenicantonio Ilaria Ruffilli Alda Corrado Silvia Fabiani Santino Marchi Clodoveo Ferri Ele Ferrannini Poupak Fallahi | 2014 | World Journal of Diabetes2014，5，5： | 7 |
| 4 | High-sensitivity integrated devices based on surface plasmon resonance for sensing applications显示文摘A metallic nanostructured array that scatters radiation toward a thin metallic layer generates surface plasmon resonances for normally incident light. The location of the minimum of the spectral reflectivity serves to detect changes in the index of refraction of the medium under analysis. The normal incidence operation eases its integration with optical fibers. The geometry of the arrangement and the material selection are changed to optimize some performance parameters as sensitivity, figure of merit, field enhancement, and spectral width. This optimization takes into account the feasibility of the fabrication. The evaluated results of sensitivity(1020 nm/RIU)and figure of merit(614 RIU^(-1)) are competitive with those previously reported. | MAHMOUD H.ELSHORBAGY ALEXER CUADRADO JAVIER ALDA | 2017 | Photonics Research2017，5，6： | 2 |
| 5 | 废墟上的图书馆显示文摘考古遗迹通常的做法是与博物馆相结合.供人们参观欣赏.而近期在休达市的一处十四世纪的阿拉伯遗址上建起了一座现代化的图书馆.人们不仅可以观看遗迹.还可以在此读书看报.而古老遗迹也为这座图书馆蒙上了一层神秘的面纱。 | 常号 Fernando Alda Manuel Garcia de Paredes | 2014 | 建筑知识2014，34，1： | 2 |
| 6 | Assessing the estrogenic potency in a Portuguese wastewater treatment plant using an integrated approach显示文摘The estrogenic potency of a wastewater treatment plant(WWTP) was evaluated using chemical and biological analyses,which showed that after the station treatment processes some of the selected endocrine disruptor compounds(EDCs) were still present in the treated effuent(e.g.,bisphenol A,alkylphenols,estrone) .Thus,the most common endocrine EDCs were identified and quantified and the overall estrogenicity of the treated effuent assessed by integrating the results.Male goldfish(Carassius auratus) were used as biological indicators in a 28-day experiment.Vitellogenin(Vtg) ,gonadosomatic and hepatosomatic indices,steroids(17β-estradiol and 11-ketotestosterone) and histopathology were biomarkers used in fish to evaluate WWTP treated effuent estrogenicity,in combination with instrumental analyses.The results showed a significant increase(P<0.01) in plasma and liver Vtg,which were significantly correlated(r=0.66;P<0.01) .The gonadosmatic index was significantly(P<0.01) reduced in exposed fish.The steroid analyses revealed significant elevations in 17β-estradiol and depressed 11-ketotestosterone concentrations.The histological examinations show changes in exposed fish gonads,such as regressed testes and in some cases(43%to 75%) the development of ovo-testis in fish exposed to 50% and 100% treated effuent. | Mário S.Diniz Rita Maurício Mira Petrovic Maria J.López De Alda Leonor Amaral Isabel Peres Damiá Barceló Fernando Santana | 2010 | Journal of Environmental Sciences2010，22，10： | 2 |
| 7 | Characterization of aberrated laser beams 显示文摘 | ALDA J ALONSO J BERNABEU E | 1997 | J O S A1997，14，10： | 1 |
| 8 | Characterization of aberrated laserbeams显示文摘 | ALDA J ALONSO J BERNABEU E | 1997 | J Opt Soc Am A1997，14，10： | 1 |
| 9 | Liquid chromatography-(tandem) mass spectrometry of selected emerging pollutants (steroid sex hormones,drugs and alkylphenolic surfactants) in the aquatic environment显示文摘 | de Alda M J L Diaz-Cruz S Petrovic M | 2003 | Journal of Chromatography A2003，1000，12： | 1 |
| 10 | Use of solid-phase extraction in various of its modalities for sample preparation in the determination of estrogens and progestogens in sediment and water显示文摘 | Lopezde Alda M J Barcelo D | 2001 | Journal of Chromatography2001，938，12： | 1 |
| 11 | Auto- mated classification of construction project documents 显示文摘 | ALDAS CARLOSH SOIBELMAN LUCIO HART JIAWEI | 2002 | Journal of Computing in Civil Engineering2002，，1： | 1 |
| 12 | Environmental Behavior and Analysis of Veterinary and Human Drugs in Soils,Sediments and Sludge显示文摘 | DIAZ-CRUZ M S LOPEZ DE ALDA M J BARCELO D | 2003 | Trends in Analytical Chemistry2003，22，6： | 1 |
| 13 | Drugs of abuse and their metabolites in the Ebro River basin : occurrence in sewage and surface water, sewage treatment plants removal efficiency, and collective drug usage estimation显示文摘 | POSTIGO C DE ALDA M J L BARCELO D | 2010 | Environ Pollut2010，36，1： | 1 |
| 14 | Detection of rabbit haemorrhagic disease virus (RHDV) in nonspeeificverteb- rate hosts sympatric to the European wild rabbit (Oryctolagus cuniculus)显示文摘 | Merchan T Rocha G Alda F | 2011 | Infect Genet Evol2011，，11： | 1 |
| 15 | Picogram per liter level determination of estrogens in natural waters and waterworks by afully automated on-line solid-phaseextraction-liquid chromatography-electrospray tandem mass spectrometry method显示文摘 | Rodriguez-Mozaz S Lopez de Alda M J Barcel D | 2004 | Anal Chem2004，76，23： | 1 |
| 16 | Endocrine disrupting compounds and other emerging contaminants in the environment: A survey on new monitoring strategies and occurrence data显示文摘 | Petrovic M Eljarrat E Lopez de Alda M J | 2004 | Analytical and Bioanalytical Chemistry2004，378，3： | 1 |
| 17 | Fast and simultaneous monitoring of organic pollutants in a drinking water treatment plant by a multi - analyte biosensor followed by LC - MS validation 显示文摘 | S Rodriguez - Mozaz M Lopez de Alda D Barcelo | 2006 | Talanta2006，69，2： | 1 |
| 18 | Determination of antimicrobials in sludge from infiltration basins at two artificial recharge plants by pressurized liquid extraction-liquid chromatography-tandem mass spectrometry显示文摘 | SILVIA DIAZ-CRUZ M JOSE LOPEZ DE ALDA M BARCELO D | 2006 | J Chromatogr:A2006，1130，1： | 1 |
| 19 | Recent advance in the mass spectrometric analysis related to endocrine disrupting compounds in aquatic environmental samples显示文摘 | PETROVIC M ELJARRAT E LOPEZ de ALDA M J | 2002 | Journal of Chromatography A2002，974，12： | 1 |
| 20 | Analysis of bisphenol A in natural waters by means of an optical immunosensor 显示文摘 | Rodriguez-Mozaz S Lopez de Alda M Barcelo D | 2005 | Water Research2005，39，20： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员