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| 1 | Molecular basis of von Hippel-Lindau syndrome in Chinese patients显示文摘背景 Von Hippel-Lindau ( VHL )症候群是预先安排的正染色体的主导的家庭癌症症候群影响个人到在用南部的汉语的 VHL 的基因基础大部分是的各种各样的 organs.The 的多重瘤 unknown.In 这研究,我们在九无关的南部的中国 families.Methods 描绘了 VHL 的变化光谱有 VHL 的临床的特征的九 probands ,二征兆并且八个无征状的家庭成员在这 study.Prenatal | SIU Wai-kwan MA Ronald Ching-wan LAM Ching-wan MAK Chloe Miu YUEN Yuet-ping LO Fai-man Ivan CHAN Kin-wan LAM Siu-fung LING Siu-cheung TONG Sui-fan SO Wing-yee CHOW Chun-chung TANG Mary Hoi-yin TAM wing-hung CHAN Albert Yan-wo | 2011 | Chinese Medical Journal2011，，2： | 6 |
| 2 | Quality and readability of online information resources on insomnia显示文摘 | Yan Ma Albert C. Yang Ying Duan Ming Dong Albert S. Yeung | 2017 | Frontiers of Medicine2017，11，3： | 3 |
| 3 | Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis显示文摘BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation. | Ka Wing Ma Kelly Hiu Ching Wong Albert Chi Yan Chan Tan To Cheung Wing Chiu Dai James Yan Yue Fung Wong Hoi She Chung Mau Lo Kenneth Siu Ho Chok | 2019 | World Journal of Gastroenterology2019，25，36： | 3 |
| 4 | Role of C11-FDG dual-tracer PET-CT scan in metastatic screening of hepatocellular carcinoma-a cost-effectiveness analysis显示文摘Background:We aimed to identify predictive factors for positron emission tomography(PET)-detected hepatocellular carcinoma(HCC)metastasis and a cost-effective approach to preoperative PET-computed tomography(CT)for detecting metastasis.Methods:Clinicopathological and survival data of HCC patients having PET-CT with 18F-fludeoxyglucose(FDG)and 11C-acetate(ACT)following contrast-enhanced CT/magnetic resonance imaging(MRI)for preoperative tumor staging were reviewed.Binary logistic regression was performed to identify predictive factors for PET-detected metastasis.A cost-benefit analysis model was built for the incurred costs and the impact of PET-CT findings on treatment strategy was studied.Results:Totally 152 patients were analyzed.Dual-tracer PET-CT detected metastasis in 17 patients(11%).By multivariate analysis,alpha-fetoprotein(AFP)≥400 ng/mL[relative risk(RR):4.30,95%confidence interval(CI):1.41-13.15,P=0.011]and bilobar disease(RR:3.94,95%CI:1.24-12.52,P=0.014)were independent predictive factors for PET-detected metastasis.PET-CT findings altered the treatment strategy for 12 patients(7.9%);three partial hepatectomies,eight episodes of transarterial chemoembolization(TACE)and one episode of ablation were avoided,with an estimated cost-saving of US$91,000,$150,000 and$10,600 respectively.Had the PET-CT been performed only for patients with AFP≥400 ng/mL or bilobar disease(n=74),metastasis would have been confirmed in 14 patients(18.9%),and the cost-saving per patient was estimated at US$1,070.Conclusions:Dual-tracer PET-CT is cost-effective and useful for preoperative HCC staging in patients with AFP≥400 ng/mL or bilobar disease.Its routine use in preoperative workup for all HCC patients is not recommended.Unilobar disease with AFP<400 ng/mL can achieve good negative predictive value for PET-detected metastasis.Screening patients with either factor can avoid unnecessary procedures and is thus cost-effective for preoperative HCC workup. | Kevin K.W.Chu Albert C.Y.Chan Ka Wing Ma Wong Hoi She Wing Chiu Dai Kenneth S.H.Chok Tan To Cheung Chung Mau Lo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 5 | Liver transplantation:would it be the best and last chance of cure for hepatocellular carcinoma with major venous invasion?显示文摘Background:Hepatocellular carcinoma(HCC)with portal vein tumour thrombus(PVTT)signifies advanced disease,whether LT confers any survival superiority over resection remains uncertain.Methods:A propensity score matched(PSM)analysis of liver transplantation(LT)and liver resection(LR)for HCC with PVTT was performed.Results:A consecutive series of 88 patients who received either LT(10 DDLTs and 3 LDLTs)or LR(n=75)respectively were recruited.Before PSM,the LT group has a higher MELD score(17.3 vs.7.8,P<0.001),lower serum AFP levels(96 vs.2,164 ng/mL,P=0.017)and smaller tumour size(4 vs.10 cm,P<0.001).The 5-year overall survival for LT and LR were 55.4%and 15.9%respectively(P=0.007).After matching for serum AFP levels and tumour size,1-,3-and 5-year overall survival for LT were 81 ng/mL,3.9 cm,80%,70%and 70%and the corresponding rates for LR were 1,417 ng/mL,5.3 cm,51.8%,19,6%and 9.8%(P value=0.12,0.27 and 0.009 respectively).Conclusions:LT is associated with significantly better oncological outcomes in HCC patients with PVTT involving the lobar or segmental level.A modest expansion of selection criteria to include small HCC with segmental PVTT should be considered. | Ka Wing Ma Albert Chi Yan Chan Kenneth Siu Ho Chok Wong Hoi She Tan To Cheung Wing Chiu Dai James Yan Yue Fung Chung Mau Lo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 6 | An exact, closed-form solution for equilibrium of trveling, sagged, elastic cables under uniformly distributed loading显示文摘The exact, closed-form solution for equilibrium of traveling, sagged, elastic cables uniformly-distributed loading is derived. Three components of displacement describing two equilibria of an extensible, traveling, elastic cable are also obtained. Illustrations of equilibrium configuration, tension distribution and displacements of cables are given. | Albert C. LUO and.C.DMOTE,Jr Department of Mechanical and Industrial Engineering, Southern Illinois University Edwardsville, Edwardsville, IL 62034-1805, USA e-mall:aluo @siue.edu Office of the President, Main Administration. Building, University of Ma | 2000 | Communications in Nonlinear Science and Numerical Simulation2000，5，1： | 2 |
| 7 | Validated model for prediction of recurrent hepatocellular carcinoma after liver transplantation in Asian population显示文摘BACKGROUND Liver transplantation(LT) is regarded as the best treatment for both primary and recurrent hepatocellular carcinoma(HCC). Post-transplant HCC recurrence rate is relatively low but significant, ranging from 10%-30% according to different series. When recurrence happens, it is usually extrahepatic and associated with poor prognosis. A predictive model that allows patient stratification according to recurrence risk can help to individualize post-transplant surveillance protocol and guidance of the use of anti-tumor immunosuppressive agents.AIM To develop a scoring system to predict HCC recurrence after LT in an Asian population.METHODS Consecutive patients having LT for HCC from 1995 to 2016 at our hospital were recruited. They were randomized into the training set and the validation set in a60:40 ratio. Multivariable Cox regression model was used to identity factors associated with HCC recurrence. A risk score was assigned to each factor according to the odds ratio. Accuracy of the score was assessed by the area under the receiver operating characteristic curve.RESULTS In total, 330 patients were eligible for analysis(183 in training and 147 invalidation). Recurrent HCC developed in 14.2% of them. The median follow-up duration was 65.6 mo. The 5-year disease-free and overall survival rates were78% and 80%, respectively. On multivariate analysis, alpha-fetoprotein > 400 ng/mL [P = 0.012, hazard ratio(HR) 2.92], sum of maximum tumor size and number(P = 0.013, HR 1.15), and salvage LT(P = 0.033, HR 2.08) were found to be independent factors for disease-free survival. A risk score was calculated for each patient with good discriminatory power(c-stat 0.748 and 0.85, respectively,in the training and validation sets). With the derived scores, patients were classified into low-(0–9), moderate-(> 9–14), and high-risk groups(> 14), and the risk of HCC recurrence in the training and validation sets was 10%, 20%, 54%(cstat 0.67) and 4%, 22%, 62%(c-stat 0.811), accordingly. The risk stratification model was validated with chi-squared goodness-of-fit test(P = 0.425).CONCLUSION A validated predictive model featuring alpha-fetoprotein, salvage LT, and the sum of largest tumor diameter and total number of tumor nodule provides simple and reliable guidance for individualizing postoperative surveillance strategy. | Ka Wing Ma Wong Hoi She Albert Chi Yan Chan Tan To Cheung James Yan Yue Fung Wing Chiu Dai Chung Mau Lo Kenneth Siu Ho Chok | 2019 | World Journal of Gastrointestinal Oncology2019，11，4： | 2 |
| 8 | The pravastatin inflammation CRP evaluation(PRINCE) : rationale and design 显示文摘 | Albert MA Staggers J Chew P | 2001 | Am Heart J2001，141，6： | 1 |
| 9 | Keratinocyte carcinoma显示文摘 | Albert MR Weinstock MA | 2003 | CA Cancer J Clin2003，53，： | 1 |
| 10 | Intravitreal bevacizumab (Avastin) for refractory pseudophakic cystoid macular edema 显示文摘 | Mason JO 3rd Albert MA Jr Vail R | 2006 | Retina2006，26，3： | 1 |
| 11 | Effect of statin therapy on C reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study显示文摘 | Albert MA Danielson E Rifai N | 2001 | JAMA2001，286，1： | 1 |
| 12 | Effect of statin therapy on creative protein levels: the pravastatin inflammation/CRP evaluation (PRINE): a randomizen trial and cohort study 显示文摘 | Albert MA Danielson E Rifai N | 2001 | JAMA2001，286，： | 1 |
| 13 | The role c-reactive protein in cardiovascular disease risk 显示文摘 | Albert MA Ridker PM | 1999 | Curr Cardio Rep1999，1，2： | 1 |
| 14 | Mechanical properties of polyphenylene-sulfide (PPS) bonded Nd-Fe-B permanent magnets 显示文摘 | Monika G G Ma B M Albert J S | 2003 | Mater Sci Eng A2003，359，： | 1 |
| 15 | Plasma concentration of C2reactive proteinand the calculated Framingham coronary heart disease risk score显示文摘 | Albert MA Glynn R J Ridker PM | 2003 | Circulation2003，108，： | 1 |
| 16 | Effect of statin ther-apy on C-reactive protein levels : the pravastatin inflamma-tion/ CRP evaluation ( PRINCE) :a randomized trial and co-hort study 显示文摘 | Albert MA Danielson E Rifai N | 2001 | JAMA2001，286，1： | 1 |
| 17 | Mechanical properties of Nylon bonded Nd-Fe-B permanent magnets显示文摘 | Monika G G Albert J S Ma B M Edgar L C Ronald O S | 2003 | Journal of Magnetism and Magnetic Materials2003，257，： | 1 |
| 18 | Mechanical properties of nylon bonded Nd-Fe-B permanent magnets 显示文摘 | Monika G G Albert J S Ma B M | 2003 | J Magn Magn Mater2003，257，： | 1 |
| 19 | Prospective study of Creactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death显示文摘 | Albert CM Ma J Rifai N | 2002 | Circulation2002，，105： | 1 |
| 20 | Prospective study of C-reactive protein, homocysteine and plasma lipid levels as predictor of sudden cardiac deat h显示文摘 | Albert CM Ma J Rifai N | 2002 | Circulation2002，105，22： | 1 |
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