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| 1 | Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression显示文摘AIM: To observe the imbalance between T helper cell Th1 and Th2 cytokines in several chronic hepatitis disease at different stages of disease progression.METHODS: We measured the cytokine levels of Th1 (IL-2 and IL-2R), Th2 (IL-10) and the pro-inflammatory cytokines (IL-6 and IL-6R and TNF and TNF-RⅠ and Ⅱ)by the ELISA technique in the sera of 33 hepatocellular carcinoma (HCC) patients and 20 chronic liver disease (CLD) patients. In addition, 20 asymptomatic hepatitis C virus carriers and 20 healthy subjects negative for hepatitis C virus(HCV) markers served as controls.RESULTS: Anti-HCV antibodies were found to be positive in 94% of HCC cases and 75% of CLD cases.On the other hand, HCV viremia was detected using RTPCR in 67% of HCC cases and 65% of CLD cases. HBsAg was positive in 9% of HCC cases and 30% of CLD cases.Also bilharzial-Ab was positive in 55% of HCC cases,65% of CLD cases and in 70% of asymptomatic carriers (ASC). HCC patients had significantly higher values of IL-2R, TNF-RⅡ (P<0.001), and TNF-RⅠ (P>0.05), but lower TNFα (P<0.001) and IL-6 (P = 0.032) in comparison to ASC. But, in comparison to non-cancer controls, HCC patients had higher values of IL-2R, IL-6R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P<0.001). CLD patients had higher IL-2R, TNF-RⅠ, and TNF-RⅡ (P<0.001) than ASC. But, in comparison to non-cancer controls, CLD patients had higher values of IL-2R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P<0.001). IL-10 was higher (though not significantly) in HCC and CLD patients than in symptomatic carriers and non-cancer controls.CONCLUSION: Liver disease progression from CLD to HCC due to HCV genotype-4 infection is associated with an imbalance between Th1 and Th2 cytokines. IL-2R,TNF-RⅠ, and TNF-RⅡ could be used as potential markers. | Abdel-Rahman N Zekri Mohammed S El-Din Ashour Ahmed Hassan Hanaa M Alam El-Din Amal MR El-Shehaby Maha A Abu-Shady | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a systematic review of published studies显示文摘 | Alam M Dokainish H Lakkis N | 2006 | J Interv Cardiol2006，19，4： | 1 |
| 3 | Hypoxia-inducible factors HIF-lalpha and HIF-2alpha in head and neck cancer: Relationship to tumor biology and treatment outcome in surgically resected patients显示文摘 | Beasley N J Leek R Alam M | 2002 | Cancer Res2002，62，9： | 1 |
| 4 | The malnutrition inflammation complex syn- drome - the micsing factor in the perio - chronic kidney disease inter- link 显示文摘 | Anand N SCC Alam MN | 2013 | J Clin Diagn Res2013，7，4： | 1 |
| 5 | Hepatic tissue endothelin-1 levels in chronic disease correlate with disease severity and ascites显示文摘 | ALAM I BASS N M BACCHETTI P | 2000 | Am J Gastroenterol2000，95，： | 1 |
| 6 | Investigation of 2D and 3 D electrospun scaffolds intended for tendon repair 显示文摘 | Bosworth LA Alam N Wang JK | 2013 | J Mater Sci Mater Med2013，24，6： | 1 |
| 7 | Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery:effect of zinc supplementation显示文摘 | Alam A N Sarker S A Wahed M A | 1994 | Gut1994，35，12： | 1 |
| 8 | Impact of resuscitation strategies on the acetylation status of cardiac histones in a swine model of hemorrhage显示文摘 | Alam H B Shults C Ahuja N | | 0，，2： | 1 |
| 9 | Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action 显示文摘 | Alam M A Subhan N Rahman M M | 2014 | Adv Nutr2014，5，4： | 1 |
| 10 | Diagnostic accuracy of Magnetic Resonance Imaging in assessment of Meniscal and ACL tear:Cor- relation with arthroscopy显示文摘 | Yaqoob J Alam MS Khalid N | 2015 | Pak J Med Sci2015，31，2： | 1 |
| 11 | Gwemline transmission and expression of a lacZ containing transgene in tilapia (Oreochromis niloticus)显示文摘 | Alam M S Popplewell A Maclean N | 1996 | Transgenic Res1996，5，： | 1 |
| 12 | Distinctiveness of Mycobacterium tuberculosis genotypes from Human immunodeficiency virus typel seropositive and seronegative patients in lima 显示文摘 | Ahmed N Caviedes L Alam M | 2003 | Peru J Clin Microbiol2003，41，4： | 1 |
| 13 | Video-assisted thoracic surgery(VATS)lobectomy:the evidence base显示文摘 | Alam N Flores RM | | 0，，03： | 1 |
| 14 | Distribution of aminoglycoside resistance genes in recent clinical isolates of Enterococcus faecalis, Enterococcus f aecium and Enterococcus avium显示文摘 | Kobayashi N Alam M Nishimoto Y | 2001 | Epidemiol Infect2001，126，2： | 1 |
| 15 | Video-assisted thoracic surgery (VATS) lobectomy: the evidence base显示文摘 | Alam N Flores RM | 2007 | JSLS2007，11，3： | 1 |
| 16 | Comparative effectiveness of nonpurpuragenic 595-nm pulsed dye laser and microsecond 1064nm neodymium: yttrium-aluminum-garnet laser for treatment of diffuse facial erythema: A double-blind randomized controlled trial 显示文摘 | Alam M Voravutinon N Warycha M | 2013 | J Am Acad Dermatol2013，69，3： | 1 |
| 17 | Atomic structure of a Na+-and K+-conducting channel显示文摘 | Shi N Ye S Alam A | | 0，，： | 1 |
| 18 | Effect of reaction time and P-content on mechanical strength of the interfaces formed between eutectic Sn-Ag solder and Au/electro- less Ni( P)/Cu bond pad 显示文摘 | Alam M O Chan Y C Tu K N | 2003 | Journal of Applied Phy- sics2003，94，6： | 1 |
| 19 | PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migra- tion by suppressing SHC-RAF-ERK and AKT signaling 显示文摘 | Thomas SL Alam R Lemke N | 2010 | Neuro Oncol2010，12，9： | 1 |
| 20 | Incidence and risk factors forlung injury after lung cancer resection显示文摘 | Alam N Park B J Wilton A | 2007 | Ann Thorac Surg2007，84，4： | 1 |
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