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| 1 | Epidemiological features and risk factors of sepsis-associated encephalopathy in intensive care unit patients: 2008-2011显示文摘背景 Encephalopathy 是败血的普通复杂并发症,并且它的发作能在败血的任何阶段发生并且暗示更坏的 prognosis.However ,发生,传染病学,并且这研究的联系败血的 encephalopathy 遗体 controversial.The 目的致病是为我们的回顾的学习包括了的联系败血的 encephalopathy.Methods 调查流行病学的特征和风险因素有败血的所有病人从排除 91 的 2008~2011 .After 承认了我们的特别护理单位P=0.013 ) ,在一台通风机上花了一显著地更长的时间((8. | ZHANG Li-na WANG Xiao-ting AI Yu-hang GUO Qu-lian HUANG Li LIU Zhi-yong Vao Bo | 2012 | Chinese Medical Journal2012，，5： | 70 |
| 2 | Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis显示文摘Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death,such as ferroptosis,apoptosis and necroptosis. However,whether iron-elevated ROS is also linked to pyroptosis has not been reported. Here,we demonstrate that iron-activated ROS can induce pyroptosis via a Tom20-Bax-caspase-GSDME pathway. In melanoma cells,iron enhanced ROS signaling initiated by CCCP,causing the oxidation and oligomerization of the mitochondrial outer membrane protein Tom20. Bax is recruited to mitochondria by oxidized Tom20,which facilitates cytochrome c release to cytosol to activate caspase-3;eventually triggering pyroptotic death by inducing GSDME cleavage. Therefore,ROS acts as a causative factor and Tom20 senses ROS signaling for iron-driven pyroptotic death of melanoma cells. Since iron activates ROS for GSDME-dependent pyroptosis induction and melanoma cells specifically express a high level of GSDME,iron may be a potential candidate for melanoma therapy. Based on the functional mechanism of iron shown above,we further demonstrate that iron supplementation at a dosage used in iron-deficient patients is sufficient to maximize the anti-tumor effect of clinical ROS-inducing drugs to inhibit xenograft tumor growth and metastasis of melanoma cells through GSDME-dependent pyroptosis. Moreover,no obvious side effects are observed in the normal tissues and organs of mice during the combined treatment of clinical drugs and iron. This study not only identifies iron as a sensitizer amplifying ROS signaling to drive pyroptosis,but also implicates a novel iron-based intervention strategy for melanoma therapy. | Bo Zhou Jia-yuan Zhang Xian-shuo Liu Hang-zi Chen Yuan-li Ai Kang Cheng Ru-yue Sun Dawang Zhou Jiahuai Han Qiao Wu | 2018 | Cell Research2018，28，12： | 52 |
| 3 | Future 5G-Oriented System for Urban Rail Transit:Opportunities and Challenges显示文摘As a development direction of urban rail transit system,the train autonomous circumambulate system(TACS)can operate in a safer,more efficient,and more economical mode.However,most urban rail transit systems transmit signals through industrial,scientific,and medical(ISM)frequency bands or narrow frequency bands,which cannot meet the requirements of TACS.As a promising solution,the 5th generation(5G)mobile communication provides more services for the future urban rail transit systems,and covers the shortages of exiting communication technologies in terms of capacity and reliability.In this paper,we first briefly review the research status of current train control system and introduce its limitations.Next,we propose a novel network architecture,and present new technologies and requirements of the proposed architecture for TACS.Some potential challenges are then discussed to give insights for further research of TACS. | Junhui Zhao Jin Liu Lihua Yang Bo Ai Shanjin Ni | 2021 | China Communications2021，18，2： | 18 |
| 4 | Stationarity Intervals of Time-Variant Channel in High Speed Railway Scenario显示文摘The non-stationary behavior, caused by the train movement, is the main factor for the variation of high speed railway channel. To measure the time-variant effect, the parameter of stationarity interval, in which the channel keeps constant or has no great change, is adopted based on Zhengzhou-Xi'an (Zhengxi) passenger dedicated line measurement with different train speeds. The stationarity interval is calculated through the definition of Local Region of Stationarity (LRS) under three train velocities. Furthermore, the time non-stationary characteristic of high speed railway channel is compared with five standard Multiple-Input Multiple-Output (MIMO) channel models, i.e. Spatial Channel Model (SCM), extended version of SCM (SCME), Wireless World Initiative New Radio Phase II (WINNERII), International Mobile Telecommunications-Advanced (IMT-Advanced) and WiMAX models which contain the high speed moving scenario. The stationarity interval of real channel is 9 ms in 80% of the cases, which is shorter than those of the standard models. Hence the real channel of high speed railway changes more rapidly. The stationarity intervals of standard models are different due to different modeling methods and scenario definitions. And the compared results are instructive for wireless system design in high speed railway. | Chen Binghao Zhong Zhangdui Ai Bo | 2012 | China Communications2012，9，8： | 15 |
| 5 | Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination显示文摘 | Yiqiang Cui Yuyu Niu Jiankui Zhou Yongchang Chen Yiwei Cheng Shangang Li Zongyong Ai Chu Chu Hong Wang Bo Zheng Xuejin Chen Jiahao Sha Xuejiang Guo Xingxu Huang Weizhi Ji | 2018 | Cell Research2018，28，3： | 13 |
| 6 | 3D Geometry-Based UAV-MIMO Channel Modeling and Simulation显示文摘A more general narrowband regular-shaped geometry-based statistical model(RS-GBSM) combined with the line of sight(LoS) and single bounce(SB) rays for unmanned aerial vehicle(UAV) multiple-input multiple-output(MIMO) channel is proposed in this paper. The channel characteristics, including space-time correlation function(STCF), Doppler power spectral density(DPSD), level crossing rate(LCR) and average fade duration(AFD), are derived based on the single sphere reference model for a non-isotropic environment. The corresponding sum-of-sinusoids(SoS) simulation models including both the deterministic model and statistical model with finite scatterers are also proposed for practicable implementation. The simulation results illustrate that the simulation models well reproduce the channel characteristics of the single sphere reference model with sufficient simulation scatterers. And the statistical model has a better approximation of the reference model in comparison with the deterministic one when the simulation trials of the stochastic model are sufficient. The effects of the parameters such as flight height, moving direction and Rice factor on the characteristics are also studied. | Rubing Jia Yiran Li Xiang Cheng Bo Ai | 2018 | China Communications2018，15，12： | 11 |
| 7 | SALVIANOLIC ACID G,A CAFFEIC ACID DIMER WITH A NOVEL TETRACYCLIC SKELETON显示文摘Salvianolic acid G,a caffeic acid dimer with a noveltetracyclic skeleton was isolated from the roots of Salviamiltiorrhiza.Its structure was elucidated by chemical and spectralanalysis,especially by 2D NMR analysis. | Chun Bo AI Lian Niang LI Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing 100050,China | 1991 | Chinese Chemical Letters1991，2，1： | 10 |
| 8 | The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8显示文摘Pyroptosis is a form of regulated cell death mediated by gasdermin family members,among which the function of GSDMC has not been clearly described.Herein,we demonstrate that the metabolite a-ketoglutarate(α-KG)induces pyroptosis through caspase-8-mediated cleavage of GSDMC Treatment with DM-αKG,a cell-permeable derivative of α-KG,elevates ROS levels,which leads to oxidation of the plasma membrane-localized death receptor DR6. | Jia-yuan Zhang Bo Zhou Ru-yue Sun Yuan-li Ai Kang Cheng Fu-nan Li Bao-rui Wang Fan-jian Liu Zhi-hong Jiang Wei-jia Wang Dawang Zhou Hang-zi Chen Qiao Wu | 2021 | Cell Research2021，31，9： | 10 |
| 9 | Differentially expressed proteins of gamma-ray irradiated mouse intestinal epithelial cells by two-dimensional electrophoresis and MALDI-TOF mass spectrometry显示文摘AIM: To identify the differentially expressed proteins involved in ionizing radiation in mice and to explore new ways for studying radiation-related proteins.METHODS: Bal B/c mice grouped as sham-irradiation, 3h and 72 h irradiation were exposed to 9.0Gy single dose of γ-irradiation. Intestinal epithelia were isolated from mice,and total proteins were extracted with urea containing solution. A series of methods were used, including twodimensional electrophoresis, PDQuest 2-DE software analysis, peptide mass fingerprinting based on matrixassisted laser desorption/ionization time of flight masss pectrometry (MALDI-TOF-MS) and SWISS-PROT database searching, to separate and identify the differential proteins.Western blotting and RT-PCR were used to validate the differentially expressed proteins.RESULTS: Mouse intestine was severely damaged by 9.0 Gy γ-irradiation. Image analysis of two-dimensional gels revealed that averages of 638±39, 566±32 and 591±29 protein spots were detected in 3 groups, respectively, and the majority of these protein spots were matched. About 360 protein spots were matched between normal group and 3 h irradiation group, and the correlation coefficient was 0.78 by correlation analysis of gels. Also 312 protein spots matched between normal group and 72 h irradiation group, and 282 protein spots between 3 h and 72 h irradiation groups. Twenty-eight differential protein spots were isolated from gels, digested with trypsin, and measured with MALDI-TOF-MS. A total of 25 spots yielded good spectra, and 19 spots matched known proteins after database searching. These proteins were mainly involved in anti-oxidation, metabolism, signal transduction,and protein post-translational processes. Western-blotting confirmed that enolase was up-regulated by γ-irradiation. Up-regulation of peroxiredoxin I was verified by applying RTPCR technique, but no change occurred in QSVC72.CONCLUSION: These differentially expressed proteins might play important roles when mouse intestine was severely injured by γ-irradiation. It is suggested that differential proteomic analysis may be a useful tool to study the proteins involved in radiation damage of mouse intestinal epithelia. | Bo Zhang Yong-Ping Su Guo-Ping Ai Xiao-Hong Liu Feng-Chao Wang Tian-Min Cheng Institute of Combined Injury of PLA,Third Military Medical University,Chongqing 400038,China | 2003 | World Journal of Gastroenterology2003，9，12： | 10 |
| 10 | A Green Paradigm for Internet of Things: Ambient Backscatter Communications显示文摘Internet of Things (IoT) has attracted extensive interest from both academia and industries, and is recognized as an ultimate infrastructure to connect everything at anytime and anywhere. The implementation of IoT generally faces the challenges from energy constraint and implementation cost. In this paper, we will introduce a new green communication paradigm, the ambient backscatter (AmBC), that could utilize the environmental wireless signals for both powering a tiny-cost device and backscattering the information symbols. Specifically, we will present the basic principles of AmBC, analyze its features and advantages, suggest its open problems, and predict its potential applications for our future IoT. | Wei Zhang Yao Qin Wenjing Zhao Minzheng Jia Qiang Liu Ruisi He Bo Ai | 2019 | China Communications2019，16，7： | 9 |
| 11 | Effects of targeting magnetic drug nanoparticles on human cholangiocarcinoma xenografts in nude mice显示文摘BACKGROUND:Targeting is a new therapeutic tool for malignant tumor as a result of combining nanotechnology with chemotherapeutics.The aim of our study was to investigate the effects of magnetic nanoparticles enveloping a chemotherapeutic drug on human cholangiocarcinoma xenografts in nude mice. METHODS:The human cholangiocarcinoma xenograft model was established in nude mice with the QBC939 cell line.The nude mice were randomly assigned to 7 groups. 0.9%saline or magnetic nanoparticles,including high (group 2),medium(group 4)and low(group 5)dosages, were given to nude mice through the tail vein 20 days after the QBC939 cell line was implanted.Calculations were made 35 days after treatment in order to compare the volumes,inhibition ratios and growth curves of the tumors in each group.Mice in each group were sacrificed randomly to collect tumor tissues and other organs for electron microscopy and pathological examination. RESULTS:The high and medium dosage groups were significantly different from the control group(P<0.05). The tumor inhibition ratios for the high,medium and low dosage groups were 39.6%,14.6%and 7.9%,respectively. The tumor growth curve of groups 5,4,and 2 changed slowly in turn.The high and medium groups showed cell apoptosis under an electron microscope.CONCLUSION:Magnetic nanoparticles can inhibit the growth of human cholangiocarcinoma xenografts in nude mice. | Tang, Tao Zheng, Jian-Wei Chen, Bo Li, Hong Li, Xi Xue, Ke-Ying Ai, Xing Zou, Sheng-Quan | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 8 |
| 12 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 13 | Prognosis of hepatic cirrhosis patients with esophageal or gastric variceal hemorrhage: multivariate analysis显示文摘Objective: To study the effect of bacterial infection,use of antibiotics, active bleeding at endoscopy, andthe severity of liver disease as prognostic factors inhepatic cirrhotic patients during the first 5 days afterthe episode of esophageal or gastric variceal hemor-rhage.Methods: Seventy-six hepatic cirrhosis patients withesophageal or gastric variceal bleeding were enrolled.Bleeding was managed in a standardized protocol u-sing octreotide and vasopressin in sclerotherapy orband ligation for active bleeding at endoscopy. Thescreening protocol for bacterial infection consisted ofchest radiograph; blood, urine and ascitic fluid cul-tures; the severity of liver disease shown by Child-Pugh score.Results: Active bleeding was observed at endoscopyin 40 patients (53%). Failure to control bleedingWithin 5 days occurred in 36 patients (45%). Empir-ical antibiotic treatment was used in 53 patients(67%), whereas bacterial infections were documen-ted in 43 patients (57%). Multivariate analysisshowed that proven bacterial infection (P<0.01) orantibiotic use (P<0.05) as well as active bleeding atendoscopy (P<0.01) and Child-Pugh score (P<0.01) were independent prognostic factors of failureto control bleeding.Conclusion: Bacterial infection is associated with fai-lure to control esophageal or gastric variceal bleedingin hepatic cirrhotic patients. | Chao Zhao Shao-Bo Chen Jian-Pin Zhou Wen Xiao Han-Gong Fan Xue-Wei Wu Gan-Xin Feng Wei-Xiong He the Department of Gatroenterology, Zhongshan Municipal Bo’ai Hospital, Zhongshan 528403, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，3： | 7 |
| 14 | Systems Pharmacology Uncovers Multiple Mechanisms of Erxian Decoction (二仙汤) for Treatment of Premature Ovarian Failure显示文摘Objective:To predict the chemical compositions and drug targets and to systematically dissect the pharmacological mechanism of Erxian Decoction(二仙汤,EXD)as a treatment for premature ovarian failure(POF)using a systems pharmacology approach.Methods:The compounds present in EXD were obtained from three databases.The active ingredient was identified by analyzing the values of oral bioavailability(OB),drug-like ness(DL),and Lipin ski's rule(LR).The active in gredients were further searched in research articles,drug targets in the DrugBank database,and the C-T and T-P networks,as well as by pathway analysis using the Cytoscape platform.Results:A total of 728 compounds were identified in EXD.Of these,59 were identified as active compounds that conformed to the criteria with OB>30%and DL>0.18.By further searches in the literature,126 related targets were ide ntified that could in teract with the active compounds.Additi on ally,it was found that the beneficial effects of EXD in POF are probably exerted via regulation of the immline system,modulation of estrogen levels,and anti-oxidative activities,and that it may act in a synergistic or cooperative manner with other therapeutic agents.Conclusions:The systems pharmacology approach is a comprehensive system that was used to elucidate the pharmacological mechanism of EXD as a treatment for POF.The results of this study will also facilitate the application of traditional medicine in modern treatment strategies. | DU Bo LIU Li-hong LV Yu-juan AI Hao | 2020 | Chinese Journal of Integrative Medicine2020，26，2： | 7 |
| 15 | AoA-Based Channel Estimation for Massive MIMO OFDM Communication Systems on High Speed Rails显示文摘Channel estimation is a well-known challenge for wireless orthogonal frequency division multiplexing(OFDM)communication systems with massive antennas on high speed rails(HSRs).This paper investigates this problem and design two practicable uplink and downlink channel estimators for orthogonal frequency division multiplexing(OFDM)communication systems with massive antenna arrays at base station on HSRs.Specifically,we first use pilots to estimate the initial angle of arrival(AoA)and channel gain information of each uplink path through discrete Fourier transform(DFT),and then refine the estimates via the angle rotation technique and suggested pilot design.Based on the uplink angel estimation,we design a new downlink channel estimator for frequency division duplexing(FDD)systems.Additionally,we derive the Cramér-Rao lower bounds(CRLBs)of the AoA and channel gain estimates.Finally,numerical results are provided to corroborate our proposed studies. | Yanrong Zhao Wenjing Zhao Gongpu Wang Bo Ai Hervin Hidayat Putra Bagus Juliyanto | 2020 | China Communications2020，17，3： | 6 |
| 16 | Synthesis and anti-tumor activity evaluation of novel podophyllotoxin derivatives显示文摘In order to investigate the effects on the cytotoxicity of indole-3-oxalylamino podophyllotoxin analogs, seven novel podophyllotoxin derivatives were synthesized.The compounds were tested against Hela, K562 or K562/A02 cancer cells in vitro,four of which showed significant cytotoxicity.Among them 9a,9b and 9c were superior to the positive control VP-16. | Ting Ai Shao-Yu Shi Li-Ting Chen Ling Li Bo Cao Ying Gao Hong Chen Jing Zhou | 2013 | Chinese Chemical Letters2013，24，1： | 5 |
| 17 | Thermal performance analysis of non-uniform height rectangular fin based on constructal theory and entransy theory显示文摘A model of non-uniform height rectangular fin, in which the variation of base's thickness and width are taken into account, is established in this paper. The dimensionless maximum thermal resistance(DMTR) and the dimensionless equivalent thermal resistance(DETR) defined based on the entransy dissipation rate(EDR) are taken as performance evaluation indexes. According to constructal theory, the variations of the two indexes with the geometric parameters of the fin are analyzed by using a finite-volume computational fluid dynamics code, the effects of the fin-material fraction on the two indexes are analyzed. It is found that the two indexes decrease monotonically as the ratio between the front height and the back height of the fin increases subjected to the non-uniform height rectangular fin. When the model is reduced to the uniform height fin, the two indexes increase first and then decrease with increase in the ratio between the height of the fin and the fin space. The fin-material fraction has no effect on the change rule of the two indexes with the ratio between the height of the fin and the fin space. The sensitivity of the DETR to the geometric parameters of the fin is higher than that of the DMTR to the geometric parameters. The results obtained herein can provide some theoretical support for the thermal design of rectangular fins. | YANG Ai Bo CHEN Lin Gen XIE Zhi Hui FENG Hui Jun SUN Feng Rui | 2016 | Science China(Technological Sciences)2016，59，12： | 4 |
| 18 | Robust power amplifier predistorter by using memory polynomials显示文摘In memory polynomial predistorter design,the coefficient estimation algorithm based on normalized least mean square is sensitive to initialization parameters.A predistorter based on generalized normalized gradient descent algorithm is proposed.The merit of the GNGD algorithm is that its learning rate provides compensation for the independent assumptions in the derivation of NLMS,thus its stability is improved.Computer simulation shows that the proposed predistorter is very robust.It can overcome the sensitivity of initialization parameters and get a better linearization performance. | Li Bo Ge Jianhua Ai Bo | 2009 | Journal of Systems Engineering and Electronics2009，20，4： | 4 |
| 19 | Exploring Genome-wide DNA Methylation Profiles Altered in Kashin-Beck Disease Using Infinium Human Methylation 450 Bead Chips显示文摘To understand how differentially methylated genes(DMGs)might affect the pathogenesis of Kashin-Beck disease(KBD).Genome-wide methylation profiling of whole blood from 12matched KBD and controls pairs was performed using a high-resolution Infinium 450 K methylation array.In total,97 CpG sites were | SHI Xiao Wei SHI Bo Hui LYU Ai Li ZHANG Feng ZHOU Tian Tian GUO Xiong | 2016 | Biomedical and Environmental Sciences2016，29，7： | 4 |
| 20 | Wireless Powered IoE for 6G: Massive Access Meets Scalable Cell-Free Massive MIMO显示文摘A key challenge to the scalable deployment of the energy self-sustainability(ESS)Internet of Everything(IoE)for sixth-generation(6G)networks is juggling massive connectivity and high spectral efficiency(SE).Cell-free massive multiple-input multiple-output(CF mMIMO)is considered as a promising solution,where many wireless access points perform coherent signal processing to jointly serve the users.However,massive connectivity and high SE are difficult to obtain at the same time because of the limited pilot resource.To solve this problem,we propose a new framework for ESS IoE networks where the user activity detection(UAD)and channel estimation are decoupled.A UAD detector based on deep convolutional neural networks,an initial access scheme,and a scalable power control policy are proposed to enable the practical scalable CF mMIMO implementation.We derive novel and exact closed-form expressions of harvested energy and SE with maximum ratio(MR)processing.Using local partial minimum mean-square error and MR combining,simulation results prove that the proposed framework can serve more users,improve the SE performance,and achieve better user fairness for the considered ESS IoE networks. | Shuaifei Chen Jiayi Zhang Yu Jin Bo Ai | 2020 | China Communications2020，17，12： | 4 |
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