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| 1 | Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats显示文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC)from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats.METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS.Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration.Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-Larginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed.RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity.Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats.Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachykinergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls.CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. | Luciano Onori Annalisa Aggio Simona D'Alo' Paola Muzi Maria Grazia Cifone Gabriella Mellillo Rachele Ciccocioppo Gennaro Taddei Giuseppe Frieri Giovanni Latella | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 2 | A new integrated approach to improve left ventricular electromechanical activation during right ventricular septal pacing显示文摘 | Pasture G Aggio S Baracca E et al | 2012 | Europace2012，14，1： | 1 |
| 3 | A feasible approach for direct his-bundle pacing using a new steerable catheter to facilitate precise lead placement显示文摘 | Zanon F Baracca E Aggio S | 2006 | J Cardiovasc Electrophysiol2006，17，1： | 1 |
| 4 | An application of PCR- DGGE analysis to profile the yeast populations in raw milk 显示文摘 | Cocolin L Aggio D Manzano M | 2002 | International Dairy Journal2002，12，5： | 1 |
| 5 | An application of PCR-DGGE Analysis to profile the yeast populations in raw milk显示文摘 | Cocolin L Aggio D Manzano M | 2002 | a2002，12，： | 1 |
| 6 | Gaueher disease type 1 : revised recommendations on evaluations and monitoring for adult patients显示文摘 | Weinreb NJ Aggio MC Andersson HC | 2004 | Semin Hematol2004，415，： | 1 |
| 7 | Acute endophthalmitis following intravitreal bevacizumab(Avastin) injection显示文摘 | Aggio FB Farah ME de Melo GB | 2007 | Eye2007，21，： | 1 |
| 8 | Influence of tidal volume on alveo lar recruitment:respective ro le of PEEP and a recruitment maneuver显示文摘 | R ichard J C M aggio re S M Jonson B | 2001 | Am J Resp ir Crit Care Med2001，163，12： | 1 |
| 9 | Biology of incretins: GLP-1 and GIP 显示文摘 | aggio LL Drucker DJ | 2007 | Gas- troenterology2007，132，6： | 1 |
| 10 | High incidence of autoantibodies in Fabry disease patients显示文摘 | Martinez P Aggio M Rozenfeld P | | 0，，： | 1 |
| 11 | A novel polymerase chain reaction (PCR)-Denaturing gradient gel electrophoresis (DGGE)for the identification of Micrococcaceae strains involved in meat fermentations显示文摘 | COCOLIN L MANZAON M AGGIO D | 2001 | Meat Science2001，57，： | 1 |
| 12 | Toxin-antitoxin sys- tems of Mycobacterium smegmatis are essential for cell survival显示文摘 | Frampton R Aggio RB Villas-Boas SG | 2012 | J Biol Chem2012，287，8： | 1 |
| 13 | Fundus autofluorescence and spectral domain OCT in central serous chorioretinopathy 显示文摘 | Roisman L Lavinsky D Magalhaes F Aggio FB Moraes N Car- diUo JA | 2011 | J Ophthalmol2011，2011，70： | 1 |
| 14 | Analyticalplatform for metabolome analysis of microbial cells using methylchloroformate derivatization followed by gas chromatography massspectrometry显示文摘 | Smart K F Aggio R B Houtte J R Villas-Bas S G | 2010 | Nat Protoc2010，5，： | 1 |
| 15 | Teayflavonoidstand nitric oxide-mediated vascular reactivity显示文摘 | GrassiD Aggio A Onori L | 2008 | The Journal of nutrition2008，138，8： | 1 |
| 16 | An application of PCR- DGGE analysis to profile the yeast populations in raw milk显示文摘 | COCOLIN L AGGIO D MANZANO M | 2002 | International Dairy Journal2002，12，5： | 1 |
| 17 | Attention in children and adolescents with headache显示文摘 | Riva D Usilla A Aggio F | 2012 | Headache2012，52，3： | 1 |
| 18 | High incidence of autoantibodies in Fabry disease patients 显示文摘 | Martinez P Aggio M Rozenfeld P | 2007 | J Inherit Metab Dis2007，30，4： | 1 |
| 19 | Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography-mass spectrometry显示文摘 | Smart K F Aggio R B M van Houtte J R | 2010 | Nat Protoc2010，5，10： | 1 |
| 20 | Serum erythropoietin and its relation with soluble transferin receptor in patients with different types of anaemia in a locally defined reference population显示文摘 | Roque ME Sandoval MJ Aggio MC | 2001 | Clin Lab Haem2001，23，5： | 1 |
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