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| 1 | Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis显示文摘Hepatocellular carcinoma(HCC) is one of the most common and aggressive cancers worldwide. HCC is the fifth common malignancy in the world and the second leading cause of cancer death in Asia. Long non-coding RNAs(lncRNAs) are RNAs with a length greater than 200 nucleotides that do not encode proteins. lncRNAs can regulate gene expression and protein synthesis in several ways by interacting with DNA, RNA and proteins in a sequence specific manner. They could regulate cellular and developmental processes through either gene inhibition or gene activation. Many studies have shown that dysregulation of lncRNAs is related to many human diseases such as cardiovascular diseases, genetic disorders, neurological diseases, immune mediated disorders and cancers. However, the study of lncRNAs is challenging as they are poorly conserved between species, their expression levels aren't as high as that of m RNAs and have great interpatient variations. The study of lncRNAs expression in cancers have been a breakthrough as it unveils potential biomarkers and drug targets for cancer therapy and helps understand the mechanism of pathogenesis. This review discusses many long non-coding RNAs and their contribution in HCC, their role in development, metastasis, and prognosis of HCC and how to regulate and target these lncRNAs as a therapeutic tool in HCC treatment in the future. | Aya El Khodiry Menna Afify Hend M El Tayebi | 2018 | World Journal of Gastroenterology2018，24，5： | 9 |
| 2 | Biochemical changes in phenols,flavonoids,tannins,vitamin E,β-carotene and antioxidant activity during soaking of three white sorghum varieties显示文摘Objective:To investigate the changes in total phenols,flavonoids,tannins,vitamin E, β-carotene and antioxidant activity during soaking of three white sorghum varieties.Methods: The changes in total phenols,total ilavonoids,tannins,phenolic acids compounds,flavonoid components,vitamin E,P-carotene and antioxidant activity during soaking of sorghum grains were determined.Results:Total phenols,total flavonoids,tannins,vitamin E,P-carotene and antioxidant activity in raw sorghum were ranged from 109.21 to 116.70,45.91 to 54.69,1.39 to 21.79 mg/100 g,1.74 to 5.25,0.54 to 1.19 mg/kg and 21.72%to 27.69%and 25.29%to 31.97%,respectively. The above measured compounds were significantly decreased after soaking.p-Hydroxybenzoic acid,vanillic acid,syringic acid and cinnamic acid represent the major phenolic acids in Dorado variety.While ferulic acid,p-coumaric acid,gallic acid and caffeic acid represent the major phenolic acids in Shandaweel-6.On the other hand,protocatechuic acid represents the major phenolic acids in Giza-15.Regarding flavonoids components,Dorado was the highest variety in kampferol and naringenin while Shandaweel-6 was the highest variety in luteolin, apigenin,hypersoid,quercelin and christen.Finally,Giza-15 was the highest variety in catechin. Phenolic acids,flavonoid compounds and antioxidant activities were decreased after soaking. Conclusions:Sorghum varieties have moderate quantities from total phenols,total flavonoids, tannins,phenolic acids compounds,flavonoid components,vitamin E,P-carotene and antioxidant activity which decreased after soaking. | Abd El-Moneim MR Afify Hossam S El-Beltagi Samiha M Abd El-Salam Azza A Omran | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，3： | 7 |
| 3 | Endoscopic management of Dieulafoy's lesion using Isoamyl-2-cyanoacrylate显示文摘Dieulafoy's lesion (DL) is a rare but important cause of obscure gastrointestinal bleeding that may be over-looked during diagnostic endoscopy. Mortality rates are similar to those of other causes for gastrointestinal bleeding. Diagnosis by upper endoscopy is the modal-ity of choice during acute bleeding. In the absence of active bleeding, the lesion resembles a raised nipple or visible vessel. There are no guidelines regarding effective selective therapy for DL, when diagnosed, en-doscopist experience is the major determinant of the treatment strategy. Following our strategy, an expert endoscopist with a skilled assistant should have a high rate of successful DL diagnosis when an obscured gas-trointestinal lesion is suspected. Cyanoacryltes com-pounds have been used successfully in management of Gastric varices and DLs. To our knowledge, there have been no previous reports regarding use of isoamyl-2-cyanoacrylate (AMCRYLATE ; Concord Drugs Ltd.,Hyderabad, India) as an effective therapy for gastric DL without serious complications. In our case study, Isoamyl-2-cyanoacrylate (AMCRYLATE) was effective and safe for treating DL. Surgical wedge resection of the lesion should be considered as a therapeutic option if endoscopic therapy fails. | Abd Elrazek M Aly Abd Elrazek Nakamura Yoko Moriguchi Hiroki Mohamed Afify Mohamed Asar Badr Ismael Magdy Salah | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 3 |
| 4 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 5 | Laboratory-based surveillance of patients with bacterial meningitis in Egypt (1998 - 2004) 显示文摘 | Afifi S Wasfy M O Azab M A | 2007 | Eur J Clin Microbiol Infect Dis2007，26，5： | 1 |
| 6 | Cucurbitacins of cucumis prophetarum and cucumis prophetarum显示文摘 | Afifi M S Ross S A Elsohly M A | 1999 | J Chem Ecol1999，25，4： | 1 |
| 7 | A Risk Identification Procedure for Construction Contracts-A Case Study of Pow er Station Projects in Egypt显示文摘 | HASSANEIN A A G AFIFY H M F | 2007 | Civil Engineering and Environmental Systems2007，24，1： | 1 |
| 8 | Investigation of DC conductivity and switching phenomenon of Se80Te20-xGex amorphous system显示文摘 | AFIFI M A HEGAB N A ATYIA H E | 2008 | Journal of Alloys and Compounds2008，463，12： | 1 |
| 9 | Expression of CD44s and CD44v6 in lung cancer and their correlation with prognostic factors 显示文摘 | Afify A M Tare S Durbin - Johnson B | | Int J Biol Markers0，26，1： | 1 |
| 10 | Stereo hidden Markov modeling for noise robust speech recognition 显示文摘 | CU1 X D AFIFY M GAO Y Q | 2013 | Computer Speech and Language2013，27，2： | 1 |
| 11 | The Effect ofAdditives on Zinc Deposited from Zinc Sulfate Solutions显示文摘 | Afifi S E Ebaid A R Hegazy M M | 1992 | JOM1992，44，1： | 1 |
| 12 | Histomorphologlc and ultrastructural lesions of the pancreas in a porcine model of intraabdominal hypertension显示文摘 | Otto J Afify M Jautz U | 2010 | Shock2010，33，6： | 1 |
| 13 | Diabetic nephropathy as a cause of end-stage renal disease in Egypt:a six-year study 显示文摘 | Afifi A EI SM E1 Sharkawy M | 2004 | East Mediterr Health J2004，10，45： | 1 |
| 14 | Association between type 2 diabetes mellitus and Helicobacter pylori infection显示文摘 | Bener A Micallef R Afifi M | 2007 | Irr Jrk J Gastroenterol2007，18，4： | 1 |
| 15 | Four- corner fusion and scaphoid excision using headless compression screws for SLAC and SNAC wrist deformities显示文摘 | Richards A A Afifi A M Moneim M S | 2011 | Tech Hand Up Extrem Surg2011，15，2： | 1 |
| 16 | A general joint additive and convolutive bias compensation approach applied to noisy Lombard speech recognition显示文摘 | Afify M Gong Y F Haton J P | 1998 | IEEE Trans on Speech and Audio Processing1998，6，6： | 1 |
| 17 | Effect of the takeup velocity on the higher-order structure of the melt-electrospun PLLA/PDLA blend fibers显示文摘 | Yamamoto M Nishikawa G Afifi A M | 2015 | Sen-I Gakkaishi2015，71，3： | 1 |
| 18 | Purification and general properties of pectin methyl eserase form curvularia inaequails NRRL 13884 in solid state culture using orange peels as an inducer 显示文摘 | Afifi A F Fawzi E M Fooaad M A | 2002 | Acta Micorbiclogica Polonica2002，51，3： | 1 |
| 19 | Emergence of a novel genotype of avian infectious bronchitis virus in Egypt 显示文摘 | Abdel-Moneim A S Afifi M A EI-Kady M F | 2012 | Arch ViroI2012，157，12： | 1 |
| 20 | Structure of meltelectrospun poly(L-lactic acid)/poly(D-lactic acid)blend fibers显示文摘 | Nishikawa G Yamamoto M Afifi A M | 2013 | Sen-I Gakkaishi2013，69，6： | 1 |
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