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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Adler D D Carson P L Rubin J M | 1990 | Ultrasound MedBiol1990，16，6： | 1 |
| 3 | Social capital:prospects for a new concept显示文摘 | ADLER P S KWON S W | 2002 | The Academy of Management Review2002，27，1： | 1 |
| 4 | Social Capital: Prospects for a New Concept 显示文摘 | Adler P Kwon S | 2002 | Acaderay of Managonent Review2002，，27： | 1 |
| 5 | Innovative ceramic materials for porous medium burners I显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Miiller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，5： | 1 |
| 6 | Large colonic lipoma mimicking colon cancer and causing colonic intussusception显示文摘 | Marzin P Sklow B Adler DG | 2008 | Dig dis sci2008，53，： | 1 |
| 7 | 显示文摘 | Adler J Baldwin P M Melia C D | 1994 | Starch1994，46，7： | 1 |
| 8 | Strategic management of technical functions 显示文摘 | Adler P S McDonald D W MacDonald F | 1992 | Sloan Management Review1992，33，2： | 1 |
| 9 | Axillary lymph node metastases:screening with (F-18) 2-fluoro-d -glucose(FDG)PET显示文摘 | ADLER L P FAULHABER P F SCHNUR K C | 1997 | Radiology1997，323，： | 1 |
| 10 | Flow in simulated porous media显示文摘 | Adler P M Jacquin C G Quiblier J A | 1990 | International Journal of Multiphase Flow1990，16，： | 1 |
| 11 | Flexibility versus efficiency?A case study of model changeovers in the Toyota production system显示文摘 | ADLER P S GOLDOFTAS B LEVINE D I | 1999 | Organization Science1999，10，1： | 1 |
| 12 | Fractal porous media IV: three-dimensional stokes flow through random media and regular fractals显示文摘 | Lemaitre R Adler P M | 1990 | Tra -nsport in porous media1990，5，： | 1 |
| 13 | Postmortem DNA changes in heart muscle显示文摘 | Adler CP Beckhove P | 1971 | BeitrPathol1971，142，3： | 1 |
| 14 | Innovative ceramic materials for porous medium burners Ⅱ显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Muller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，6： | 1 |
| 15 | Use of skin substitutes in treatment of large hypertrophic scars due to burn injury 显示文摘 | Brychta P Adler J Horky D | 2000 | Rozhl Chir2000，79，1： | 1 |
| 16 | Possible participation of nitric oxide in the increase of norepinephrine release caused by angiotensin peptides in rat atria显示文摘 | HIRONACCI M M LOVENZO P S ADLER GRASCHINSKY E | 1997 | Hypertension1997，29，6： | 1 |
| 17 | Social Capital: Prospects for a NewConcept 显示文摘 | Adler P S S W Kwon | 2002 | Academy of Management Review2002，27，1： | 1 |
| 18 | Social capital :prospects for a new concept 显示文摘 | Adler P S Kwon S W | 2002 | The Academy of Management Re- view2002，27，1： | 1 |
| 19 | Starch damage part 1 : Characterization of granule damage in ball-milled potato starch study by SEM 显示文摘 | Baldwin P M Adler J Davies M C | 1995 | Starch1995，47，： | 1 |
| 20 | Modulation of neuro- pathic pain by a glial-derived factor 显示文摘 | Adler JE Nico L VandeVord P | 2009 | Pain Med2009，10，7： | 1 |
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