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| 1 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 2 | 显示文摘 | Adler J Baldwin P M Melia C D | 1994 | Starch1994，46，7： | 1 |
| 3 | Flow in simulated porous media显示文摘 | Adler P M Jacquin C G Quiblier J A | 1990 | International Journal of Multiphase Flow1990，16，： | 1 |
| 4 | A prospective comparison of capsule endoscopy and push enteroscopy in patients with GI bleeding of obscure origin显示文摘 | Adler DG Knipschield M Gostout C | 2004 | Gastrointestinal Endoscopy2004，59，4： | 1 |
| 5 | Immuno-PCR: High sensitivity detection of proteins by nucleic acid amplification 显示文摘 | Niemeyer C M Adler M Wacker R | 2005 | Trends Biotechnol2005，23，4： | 1 |
| 6 | COMT inhibition:a new treatment strategy for Parkinson's disease显示文摘 | Kurth M C Adler C H | 1998 | Neurology1998，50，5： | 1 |
| 7 | Imaging of conductivity changes and electrode movement in EIT显示文摘 | Soleimani M G6mez-Laberge C Adler A | 2006 | Physiol Meas2006，27，5： | 1 |
| 8 | Starch damage part 1 : Characterization of granule damage in ball-milled potato starch study by SEM 显示文摘 | Baldwin P M Adler J Davies M C | 1995 | Starch1995，47，： | 1 |
| 9 | Stereotactic radiosurgical treatment of cranial and spinal hemangioblastomas显示文摘 | Moss J M Choi C Y Adler J R | 2009 | Neurosurgery2009，65，1： | 1 |
| 10 | Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coro nary artery disease显示文摘 | Vasa M Fichtlscherer S Aicher A Adler K Urbich C Martin H | 2001 | Cire Res2001，89，： | 1 |
| 11 | High resolution imaging of starch granule surfaces by atomic force microscopy显示文摘 | Baldwin P M Adler J Davies M C | 1998 | Journal of Cereal Science1998，27，： | 1 |
| 12 | Familial transmission of risk factors in the first-degree relatives of schizophrenic people显示文摘 | WALDO M C ADLER L E LEONARD S | 2000 | Biol Psychiatry2000，47，： | 1 |
| 13 | Increased gene expression of Alzheimer disease β-amyloid precursor protein in senecent cultured fibroblasts显示文摘 | Coronel C Shelton E | 1991 | Proc Natl Acad Sci USA1991，88，： | 1 |
| 14 | Combination of DNA-directed immobilization and immuno-NCR:very sensitive,antigen detection by means of self-assembled DNA-protein conjugates显示文摘 | Niemeyer C M Wacker R Adler M | 2003 | Nucleic Acids Res2003，31，16： | 1 |
| 15 | fMRI of neuronal activation with symptom provocation in unmedicated patients with obsdessive - compulsive disorder 显示文摘 | ADLER C M MCDONOUGH RYAN P SAX K W | 2000 | J Psychiatr Res2000，34，4： | 1 |
| 16 | Detecting antigens by quantitative immuno-PCR(Qipcr)显示文摘 | Niemeyer C M Adler M Wacker R | 2007 | Nature Protocols2007，2，8： | 1 |
| 17 | Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease 显示文摘 | Vasa M Fichtlscherer S Aicher A Adler K Urbich C Martin H | 2001 | Circ Res2001，89，1： | 1 |
| 18 | High Resolution Imaging of Starch Granule Surfaces by Atomic Force Microscopy显示文摘 | Baldwin P M Adler J Davies M C | 1998 | Journal of Cereal Science1998，27，： | 1 |
| 19 | High resolu- tion imaging of starch granule surfaces by atomic force mi- croscopy 显示文摘 | Baldwin P M Adler J Davies M C | 1998 | Journal of Cereal Science1998，27，3： | 1 |
| 20 | The effects of solvents on embryonic stem cell differentiation显示文摘 | Adler S Pellizzer C Paparella M | 2006 | Toxicol In Vitro2006，20，3： | 1 |
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