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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Expression ofFGF and FGF receptor genes in human breast cancer显示文摘 | H Penault-Llorca F Bertucci F Adelaide J | 1995 | Int JCancer1995，61，2： | 1 |
| 3 | New types of MYST3CBP and CBP-MYST3 fusion transcripts in t (8,16) (p11, p13) a cute myeloid leukemias 显示文摘 | Murati A Adelaide J Quiliehini B | 2007 | Haematologica2007，92，2： | 1 |
| 4 | A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma显示文摘 | Adelaide J Perot C Gelsi-Boyer V | 2006 | Leukemia2006，20，： | 1 |
| 5 | Detailed map of a re- gion commonly amplified at llq13 - - > q14 in human breast carcinoma显示文摘 | Bekri S Adelaide J Merscher S | 1997 | Cytogenet Cell Genet1997，79，12： | 1 |
| 6 | Mutations and deletions of AR- IDIA in breast tumors显示文摘 | Cornen S Adelaide J Bertucci F | 2012 | Oncogene2012，31，38： | 1 |
| 7 | Expression of the FGFR-I gene in human breast carcinoma ceils 显示文摘 | Jacquemier J Adelaide J Pare P | 1994 | Int J Cancer1994，59，3： | 1 |
| 8 | PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t (8; 9) translocation显示文摘 | Murati A Gelsi-boyer V Adelaide J | 2005 | Leukemia2005，19，9： | 1 |
| 9 | Genome profi ling of pancreatic adenocarcinoma显示文摘 | Birnbaum DJ Adelaide J Mamessier E | 2011 | Genes Chromosomes Cancer2011，50，6： | 1 |
| 10 | Integrated profiling of basal and luminal breast cancers显示文摘 | Adelaide J Finetti P Bekhouche I | 2007 | Cancer Res2007，67，24： | 1 |
| 11 | VEGF-C and VEGFR3 expression in human thyroid pathyrologies显示文摘 | Shushanov S Brontein M Adelaide J | 2000 | Int J Cancer2000，86，1： | 1 |
| 12 | Integrated profiling of basal and luminal breast cancers 显示文摘 | ADELAIDE J FINETO P BEKHOUCHE I | 2007 | Cancer Res2007，67，11： | 1 |
| 13 | Detailed map of a region commonly amplified at 11q13-q14 in human breast carcinoma 显示文摘 | Bekri S Adelaide J Merscher S | 1997 | Cytogenet Cell Genet1997，79，12： | 1 |
| 14 | Integrated profiling of basal and luminal breast cancers显示文摘 | Adelaide J Finetti P Bekhouche I | 2007 | Cancer Res2007，67，11： | 1 |
| 15 | Esophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1显示文摘 | Adelaide J Monges G Derderian C | 1995 | Br J Cancer1995，71，1： | 1 |
| 16 | VEGF-C and VEGFR- 3 expression in human thyroid pathyrologies 显示文摘 | SHUSHANOV S BRONETEIN M ADELAIDE J | 2000 | Int J Cancer2000，86，1： | 1 |
| 17 | VEGFe and VEGFR3 expression in human thyroid pathologies显示文摘 | SHUSHANOV S BRONSTEIN M ADELAIDE J | 2000 | Int J Cancer2000，86，1： | 1 |
| 18 | Optimization of immunohistochemical detection of ERBB2 in human breast cancer:impact of fixation显示文摘 | Penault-Llorca F Adelaide J Houvenaeghel G | 2013 | J Pathol2013，193，1： | 1 |
| 19 | Genome profiling of pancreatic adenocarcinoma 显示文摘 | Birnbaum D J Adelaide J Mamessier E | 2011 | Genes Chromosomes Cancer2011，50，6： | 1 |
| 20 | Optimization of immunohistochemical detection of erbB2 in human breast cancer: impact of fixation 显示文摘 | Penault-Llorca F Adelaide J Houvenaeghel G | 1994 | J Pathol1994，173，： | 1 |
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