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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 3 | Principal component analysis of dissolution data with missing elements显示文摘 | Adams E Walczak B Vervaet C Risha P G Massart D L | 1997 | Chemometrics and intelligent aboratory systems1997，，32： | 2 |
| 4 | Calculation of the effects of protonation on rigid-rod polymers显示文摘 | Farmer B L Dudis D S Adams W W | 1994 | Polymer1994，35，17： | 1 |
| 5 | ZNF265--a novel spliceosomal protein able to induce alternative splicing显示文摘 | Adams D J Van der Weyden L Mayeda A | 2001 | J Cell Biol2001，154，1： | 1 |
| 6 | Regulator of G protein signaling 5 marks peripheral arterial smooth muscle cells and is downregulated in atherosclerotic plaque显示文摘 | LI J ADAMS L D WANG X | 2004 | J Vasc Surg2004，40，3： | 1 |
| 7 | Central pontinemyelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients 显示文摘 | Adams R D Victor M Mancall E L | 1959 | AMA Arch Neurol Psychiatry1959，81，4： | 1 |
| 8 | The ras-association domain family (RASSF) members and their role in human tumourigenesis显示文摘 | Van der Weyden L Adams D J | | 0，，01： | 1 |
| 9 | Analytical models of adhesively bonded joints-Part I:literature survey显示文摘 | da Silva L F M das Neves P J C Adams R D | 2009 | International Journal of Adhesion and Adhesives2009，29，3： | 1 |
| 10 | The effect of chlorhexidine on defined, mixed culture oral biofilms grown in a novel model system显示文摘 | Kinniment S L Wimpenny J W T Adams D | 1996 | JAppl Bacterio1996，181，： | 1 |
| 11 | Nonalcoholic fatty liver disease 显示文摘 | ADAMS L A LINDOR K D | 2007 | Ann Epidemiol2007，17，11： | 1 |
| 12 | Viewpoint:experimental recovery of geometrically necessary dislocationdensity in polycrystals显示文摘 | EL-DASHER B S ADAMS B L ROLLETT A D | 2003 | Scripta Materialia2003，48，2： | 1 |
| 13 | 查看详情显示文摘 | (f)Kasparec J Adams J L Sisko J Silva D J | | 0，，： | 1 |
| 14 | Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate显示文摘 | de Oliveira A Adams S D Lee L H | | 0，，： | 1 |
| 15 | ACC/AHA2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction显示文摘 | Anderson J L Adams C D Antman E M | 2007 | Journal of the American College of Cardiology2007，50，7： | 1 |
| 16 | Professionalism beha- viors of hospital nurse executives and middle managers in 10 western states显示文摘 | Adams D Miller B K Beck L | 1996 | West J Nurs Res1996，18，1： | 1 |
| 17 | MPA and MPP Students: Twins, Siblings, or Distant Cousins? 显示文摘 | INFELD D L ADAMS W C | 2011 | Journal of Public Affairs Education2011，17，2： | 1 |
| 18 | bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells显示文摘 | Cory S Adams J M | 1998 | Nature1998，335，89： | 1 |
| 19 | The nondirected live-kindey donor:ethical considerations and practice guideline:a national conference report显示文摘 | ADAMS P L COHEN D J DANOVITCH G M | 2002 | Transplantation2002，74，4： | 1 |
| 20 | Comparative eco- toxicity of nanoscale TiO2, SiO, and ZnO water sus- pensions 显示文摘 | Adams L K Lyon D Y Alvarez P J | 2006 | Water Research2006，40，19： | 1 |
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