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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | N-acetylcysteine treatment normalizes serum tumor necrosis factor-alpha level and hinders the progression of cardiac injury in hypertensive rats显示文摘 | Bourraindeloup M Adamy C Candiani G | 2004 | Circulation2004，110，14： | 1 |
| 3 | Adenovious - mediated overexpression of tissue inhibitor of metalloproteinase - 1 reduces atherosclerotic lesions in apolipoprotein E - deficient mice显示文摘 | Rouis M Adamy C Duverger N | 1999 | Circulation1999，100，5： | 1 |
| 4 | Cardiac modulations ofANGⅡreceptor expression in rats with hypoxic pulmonary hyperten-sion显示文摘 | Adamy C Oliviero P Eddahibi S | 2002 | Am J Physiol Heart Circ Physiol2002，283，2： | 1 |
| 5 | Performance of broiler chickens supplemented with Bacillus coagulans as probiot 显示文摘 | Cavazzoni V Adami A Castrovilli C | 1998 | Br Pouh Sci1998，39，4： | 1 |
| 6 | Power-law distribution of the world wide web显示文摘 | Adami c L A Huberman B A | 2000 | Science2000，287，： | 1 |
| 7 | Performance of broil- er chickens supplemented with Bacillus coagulans as probiotic显示文摘 | CAVAZZONI V ADAMI A CASTROVILLI C | 1998 | Br Poult Sci1998，39，4： | 1 |
| 8 | Per-formance of broiler chickens supplemented with Ba- cillus coagulans as probiotic 显示文摘 | CAVAZZONI V ADAMI A CASTROVILLI C | 1998 | British Poultry Sci- ence1998，39，4： | 1 |
| 9 | SI00B expression in CSF and effects on microglia显示文摘 | Adami C Sorci G Blasi E | 2001 | Glia2001，33，2： | 1 |
| 10 | The impact of multidrug resistance on the pathogenicity of Escherichia coli an experimental study显示文摘 | Bristianou M Panagou C Adamis T | 2008 | Int J Antimicrob Agents2008，31，3： | 1 |
| 11 | Performance of broiler chickens supplemented with Bacillus coagulans as probiotic显示文摘 | Cavazzoni V Adami A Castrovilli C | 1998 | Brit Poultry Sci1998，39，： | 1 |
| 12 | Optimal performance and delocalization in NK fitness landscapes显示文摘 | Campos P R A Adami C Wilke C O | 2002 | Physica A2002，304，34： | 1 |
| 13 | Performance of broiler chickens supplemented with Bacillus coagulans as probiotic 显示文摘 | Cavazzoni V Adami A Castrovilli C | 1998 | British Poultry Science1998，39，4： | 1 |
| 14 | Evalu- ation of peri-operative epidural analgesia with ropivacaine,ropiva- caine and sufentanil, and ropivacaine, sufentanil and epinephrine in isoflurane anesthetized dogs undergoing tibial plateau levelling osteotomy显示文摘 | ADAMI C VERES-NYEKI K SPADAVECCHIA C | 2012 | Vet J2012，194，2： | 1 |
| 15 | Drug use and per ceived health in recently hospitalized older people显示文摘 | Ulfvarson J Adami J Bardage C | 2005 | Br J Community Nus2005，10，5： | 1 |
| 16 | Environmental effects on the galaxy luminosity in the cluster of galaxies AbeU 496 显示文摘 | Durret F Adami C Lobo C | 2002 | A&A2002，393，： | 1 |
| 17 | Performance of broiler chickens supplemented with Bacillus coagulans as pro-biotic显示文摘 | Cavazzoni V Adami A Castrovilli C | 1998 | Br Poult Sci1998，39，4： | 1 |
| 18 | Epidemiology of primary hyper- paralhyroidism in Europe 显示文摘 | Adami S Mareoeei C Gatti D | 2002 | J Bone Miner Res2002，17，2： | 1 |
| 19 | Assessment of Suspected Breast Cancer by MRI:A Prospective Clinical Trial Using a Combined Kinetic and Morphologic Analysis显示文摘 | Wiener J I Schilling K J Adami C | 2005 | AJR2005，184，3： | 1 |
| 20 | Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-1 reduces atherosclerotic lesions in apolipo protein E-deficient mice显示文摘 | Rouis M Adamy C Duverger N | 1999 | Circulation1999，100，5： | 1 |
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