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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 3 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 4 | A frequency domain method for estimating the parameters of a non-linear structural dynamic model through feedback显示文摘 | D E Adams R J Allemang | 2000 | Mechanical Systems and Signal Processing2000，14，4： | 1 |
| 5 | Complementary DNA sequencing: expressed sequence tags and the human genome project显示文摘 | Adams M D Kelley J M Gocayne J D | 1991 | Science1991，252，5013： | 1 |
| 6 | An intergroup phase Ⅲ comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer 显示文摘 | Adelstein D J Li Y Adams GL | 2003 | J Clin Oncol2003，21，： | 1 |
| 7 | Changes in the epidemiolngic profile of sudden infant death syndrome as rates decline among California infants:1990-1995显示文摘 | Adams E J Chavez G F Steen D | 1998 | Pediatrics1998，102，6： | 1 |
| 8 | Complementary DNA sequencing:expressed sequence tags and human genome project 显示文摘 | Adams M D Kelly J M Goeayne J D | 1991 | Science1991，252，： | 1 |
| 9 | ZNF265--a novel spliceosomal protein able to induce alternative splicing显示文摘 | Adams D J Van der Weyden L Mayeda A | 2001 | J Cell Biol2001，154，1： | 1 |
| 10 | The sequence of the human genome显示文摘 | Venter J C Adams M D Myers E W | 2001 | Science2001，291，： | 1 |
| 11 | Classification of multispectral images based on fractions of endmembers:Application to land-cover change in the Brazilian Amazon显示文摘 | Adams J B Sabol D E Kapos V | 1995 | Remote Sensing of Environment1995，52，2： | 1 |
| 12 | The energy spectra of heavy nuclei measured by the ATIC experi- ment显示文摘 | PANOV A D ADAMS J H AHN H S | 2006 | Advances in Space Research2006，37，10： | 1 |
| 13 | Heart disease and stroke statistics-2010 update:a report from the American Heart Association显示文摘 | WRITING GROUP MEMBERS Lloyd-Jones D Adams R J | 2010 | Circulation2010，121，7： | 1 |
| 14 | The environmental fate of phthalate esters: a literature review显示文摘 | Stales C A Peterson D R Parkerton T F Adams W J | 1997 | Chemosphere1997，35，4： | 1 |
| 15 | Maintenance of neuroepi-thelial progenitor cells by Delta-Notch signalling in the embryonicchick retina显示文摘 | Henrique D Hirsinger E Adam J | 1997 | Curr Biol1997，7，： | 1 |
| 16 | Rheological character-ization of animal fats and their mixtures with#2 fuel oil显示文摘 | GOODRUM J W GELLER D P ADAMS T T | 2003 | BiomassBioenergy2003，24，3： | 1 |
| 17 | Regulator of G protein signaling 5 marks peripheral arterial smooth muscle cells and is downregulated in atherosclerotic plaque显示文摘 | LI J ADAMS L D WANG X | 2004 | J Vasc Surg2004，40，3： | 1 |
| 18 | A Vibration Technique for Non-Destructively Assessing the Integrity of Structures显示文摘 | Adams R D Cawley P Pye C J | 1978 | Journal of Mechanical Engineering Science1978，，20： | 1 |
| 19 | Rapid PCRbased identification of apple(Malus)cultivars and species显示文摘 | Mort on A Adams A N Barbara D J | 1993 | BCPC Monograph1993，54，： | 1 |
| 20 | Alzheimer’s disease,ceramide,visfatin andNAD显示文摘 | ADAMS J D Jr | 2008 | CNS&Neurological Disorders Drug Targets2008，7，6： | 1 |
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