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| 1 | Inflammatory bowel disease: Traditional knowledge holds the seeds for the future显示文摘Despite the level of sophistication they have reached nowadays, the available tools for treatment of inflammatory bowel disease(IBD) can at best chronicize the disease but not cure it. Chances to make leap forward from this hold-back may include designs to reach personalized treatment strategies taking advantage of modern genome associated studies, and shift resources towards unfolding inciting pathogenetic steps rather than continuing to develop drugs that address down-stream phenomena. We have arbitrarily chosen to scrutinize a few projects that may make their way in 2015 and mark the history of IBD research. The list includes: the role of appendix as a regulating factor in pathogenesis of ulcerative colitis/proctitis; the reappraisal of(auto)immune phenomena in the era of microbiome; projects to treat IBD by stem cell infusion; recognition of the crucial pathogenetic role of gut microbiome, and attempts to modify it to treat enteric diseases, from clostridium difficile infection to IBD. | Giovanni C Actis Rinaldo Pellicano Floriano Rosina | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，2： | 6 |
| 2 | Inflammatory bowel disease:An archetype disorder of outer environment sensor systems显示文摘The pathogenesis of the two inflammatory bowel disease(IBD) phenotypes ulcerative colitis(UC) and Crohn' s disease(CD) has remained elusive,thus frustrating attempts at defining a cure.IBD often presents as a complex inflammatory process wherein colon lesions(UC) or widespread ulceration and fissure(CD) might be accompanied by ancillary extra-intestinal manifestations involving the eye,skin,joints or liver,but also by full-blown 'autoimmune' disorders from psoriasis and multiple sclerosis to rheumatoid arthritis;attempts at unraveling a link or a hierarchical order in these entities have proven almost fruitless.More recently,the input of genetics has suggested that the IBDs might be multiorgan inflammatory processes,elicited by a large number of low-penetrance susceptibility genes,with environmental factors needed to induce full-blown disease.At a noteworthy exception to this rule,the description of the nucleotide-oligomerization domain(NOD) gene mutations in CD came at the beginning of the 2000s:the NOD-LRR are part of a highly conserved microbial sensor system which respond to bacterial peptidoglycans by mounting an inflammatory response.At least in Caucasian patients,the prevalently loss-of-function mutation of NOD permitted to unexpectedly define CD as an immune deficiency state,and upon its recent description in apparently unrelated disorders such as the Blau syndrome(a granulomatous pediatric syndrome),and perhaps in psoriasis and chronic obstructive pulmonary disorders,has contributed to revolutionize our view of IBD and CD in particular.The latter affection,together with psoriasis and chronic pulmonary disease can now be included into a newly identified category named 'barrier organ disease',wherein a barrier organ is defined as a large mucosal or epithelial surface with an abundant metagenomic microbial population and an underneath reactive tissue,the whole structure being in contact with the outer environment and capable to react to it.Personalized treatments and empowerment of research across different disease phenotypes should be the advantages of this novel mindset. | Giovanni C Actis Floriano Rosina | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，3： | 5 |
| 3 | 中阿40m射电望远镜选址与电磁环境监测显示文摘优良站址的选择是射电望远镜完成既定科学目标并实现高效运行的重要保障。影响射电望远镜选址的主要因素包括电磁环境、水文、气象、地质条件、隔离性与可及性等。对于射电天文观测而言,来自宇宙天体的射电信号往往极其微弱,对望远镜系统及设备的灵敏度要求极高。然而,随着人类活动的不断加强,人们日常工作和生活中使用的电子通讯设备越来越多,无线电干扰源呈爆炸式涌现。在射电望远镜选址工作中,进行电磁环境监测,选择一个电磁环境良好的站址,对于射电望远镜实现常规观测运行、获取有效数据资料至关重要。同时,电磁环境监测结果也是射电望远镜接收机系统研制、站址电磁环境及无线电宁静区立法保护的重要依据。中阿天文学者和技术人员历时1年半完成了16个候选站址的初步勘察,并对优选出的3个主要候选站址进行了深入细致的电磁环境监测工作,获得了大量可靠数据。中阿双方依据电磁环境监测结果并结合各主要候选站址的水文、气象、地质及道路等条件,最终将位于Talacasto戈壁的3号候选站址确定为中阿CART射电望远镜的建设站点。 | 赵卫普 李建斌 李金增 孙建民 齐力 罗滔 马晓耘 莫铠玮 李鹏程 夏跃兵 MALLAMACI C C PODESTA R C PACHECO A M ACTIS E CASTRO J I ALVIS R H LOPEZ C E FRANCILE C PODESTA F PEREZ J | 2014 | 天文学进展2014，32，3： | 4 |
| 4 | Inflammatory bowel diseases: Current problems and future tasks显示文摘Current knowledge on inflammatory bowel disease(IBD)is mainly endorsed by controlled trials and epidemiologic studies. Yet,we seldom look at the messages from real-world practice. Among a patient population followed since2008,we looked at an unselected sample of 64 IBD patients [26 Crohn's disease(CD) and 38 ulcerative colitis(UC)] who had been seen as out-patients in the last year.Inducing remission,mesalamines(86% for UC/69% for CD/33%-16% as MMX formulation) prevailed as prescrip-tions; steroids(55%/19% for UC/CD) ranked second.Prescription of third-party drugs(antibiotics,NSAIDs,biologics) and adherence,were issues in the maintenance.34% of CD,and 23% of UC patients showed accompany-ing immunologic diseases: CD-associated familiar psoriasis(4:9) ranked first. Main Message. The association between IBD(CD mainly) and psoriasis,now found in our practice,matches current basic science gathering IBD together with psoriasis(and perhaps chronic respiratory disease) under the comprehensive term 'barrier organ disease' wherein an epithelial surface with sensor system srules contacts between outer antigens and a reactive underneath tissue,with the balance between inflammation and quiescence kept at any time by mucosal permeability.IBD is thus viewed as a polyfactorial/polygenic/syndromic disorder,embedded into a galaxy of immune conditions offering multiple points of attack. This mindset of splitting the IBDs into pathogenic categories may allow overcoming the uniformly targeting of a single cytokine by biological drugs,in favor of demarcating the boundaries between different disease-subtype-specific indications,and paving the way to future personalized strategies. | Giovanni C Actis Floriano Rosina Rinaldo Pellicano | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 3 |
| 5 | Successful operation of a cooperative SLR station of China and Argentina in San Juan显示文摘We introduced the observations and researches using a Satellite Laser Ranging (SLR) system with high precision, which was designed and made in China and installed in the Observatory of San Juan Uni- versity, Argentina, the capability of the system and the achievement of the cooperative procedure be- tween China and Argentina. The SLR station in San Juan, set up by China and Argentina, is quite sig- nificant for improving the distribution of SLR stations and enhancing the orbital coverage of the whole earth. Since the SLR system started to work in the Observatory of San Juan University in the beginning of 2006, the operation is rather good, and rich data with high precision have been obtained. Further plan of the cooperation for the near future is also presented. | HAN YanBen LIU WeiDong E ACTIS R PODESTA WANG TanQiang GUO TangYong QU Feng A M PACHECO A A GONZALEZ E ALONSO XIANG QingGe HUANG DongPing YIN ZhiQiang | 2008 | Chinese Science Bulletin2008，53，16： | 2 |
| 6 | 南美SLR监测的2010年智利8.8级大地震产生的地面位移显示文摘2010年2月27日,智利发生了8.8级特大地震,该地震使震中附近的地面产生了较大位移.德国与智利合作的卫星激光测距系统SLR-7405距震中仅约130km,其观测受到地震的影响.中国科学院国家天文台与阿根廷合作的SLR-7406系统距震中约600km,利用这两个SLR站的观测资料并结合全球SLR站的观测资料,在ITRF2000下解算了这两个SLR站点的地心坐标,发现两站的坐标都发生了不同程度的变化.SLR-7405站整体向西南方向发生了较大移动,在X,Y,Z方向上的位移量分别约为3.11,0.52和0.49m,SLR-7406站在3个方向上的位移量分别约为0.02,0.03和0.02m.由SLR这一独立的观测手段得到的结果可以为其他定位观测提供必要的外部检核. | 尹志强 韩延本 PODESTA Ricardo 刘卫东 PACHECO Ana ALONSO Ester ACTIS Eloy 黄东平 赵励民 王锐 夏金超 | 2011 | 科学通报2011，56，2： | 2 |
| 7 | Acinetobacter baumannii:human infections, factors contributing to pathogenesis and ani-mal models 显示文摘 | Mcconnell M J Actis L Pachon J | 2013 | FEMS Microbiol Rev2013，37，2： | 1 |
| 8 | Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models显示文摘 | MCCONNELL M J ACTIS L PACHON J | 2013 | Fems Microbiol Rev2013，37，2： | 1 |
| 9 | Acinetobacter bauman- nii : Human infections, factors contributing to pathogenesis and animal models显示文摘 | Me Connell MJ Actis L Pachon J | 2013 | FEMS Microbiol Rev2013，37，2： | 1 |
| 10 | Long term follow-up of cardiac myxomas(7~13years)显示文摘 | De Benedictis M Actis Dato A | 1993 | J Cardiovasc Surg1993，34，2： | 1 |
| 11 | Longterm follow-up of cardiac myxomas(7-31 years)显示文摘 | Actis Dato GM De Benedictis M Actis Dato A | 1993 | J Cardiovasc Surg1993，34，2： | 1 |
| 12 | Inhibition of angiotensin converting enzyme (ACE) activity by flavan - 3 - ols and procyanidins 显示文摘 | Lucas Actis -Goretta Javier I Ottaviani Carl L Keen | 2003 | FEBS let- ters2003，555，3： | 1 |
| 13 | Regulation of Acinetobacter baumannii bio film formation显示文摘 | Gaddy JA Actis LA | 2009 | Future Microbiol2009，4，3： | 1 |
| 14 | Dehydration of mildronate dihydrate: a study of structural transformations and kinetics 显示文摘 | BēRZI?? A ACTI?? A | 2014 | CrystEngComm2014，16，19： | 1 |
| 15 | The Acinetobacter bauman- nii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and in the interaction of this pathogen with eukaryotic cells显示文摘 | Gaddy J A Tomaras A P Actis L A | 2009 | Infect Immun2009，77，8： | 1 |
| 16 | South American SLR stations monitoring ground displacement caused by the M8.8 Chilean earthquake of 2010显示文摘The M8.8 Chilean earthquake of February 27,2010 caused a large surface displacement near its epicenter.Satellite Laser Ranging(SLR) station 7405,cooperatively operated by Germany and Chile about 130 km from the epicenter was affected by the earthquake.Another SLR station,No.7406,operated jointly by the National Astronomical Observatories of the Chinese Academy of Sciences and San Juan University of Argentina,was about 600 km from the epicenter.Combining the observations of these two SLR stations with global SLR station observations,we calculate the geocentric coordinates of the two stations based on ITRF2000.The results show that the coordinates of the two stations have changed by varying degrees.SLR-7405 moved substantially towards the southwest with displacements of about 3.11,0.52 and 0.49 m in X,Y,Z directions;the corresponding displacements for SLR-7406 are about 0.02,0.03 and 0.02 m.This solution,as an independent result derived from SLR observations,could provide an essential external check for other positioning techniques such as GPS. | YIN ZhiQiang HAN YanBen PODESTA Ricardo LIU WeiDong PACHECO Ana ALONSO Ester ACTIS Eloy HUANG DongPing ZHAO LiMin WANG Rui XIA JinChao | 2011 | Chinese Science Bulletin2011，56，8： | 1 |
| 17 | Eyelid benign and malig- nant tumors: issues in classification, excision and reconstruction 显示文摘 | Actis AG Actis G De Sanctis U | 2013 | Minerva Chir2013，68，： | 1 |
| 18 | Long - term follow- up of cardiac myxomas(7 ~ 31 year) 显示文摘 | Actis Dato GM de Benedictis M Dato AA Jr | 1993 | Cardiovasc Surg1993，34，： | 1 |
| 19 | Detection and analysis of iron uptake components expressed by Acinetobacter baumannii clinical isolates显示文摘 | orsey CW Beglin MS Actis LA | 2003 | J Clin Microbiol2003，41，9： | 1 |
| 20 | Too large resection of pectus excavatum in young patients:A reason to worry?显示文摘 | Actis Dato GM Cavaglia M Actis Dato A | | 0，，： | 1 |
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