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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | 阿司匹林及氯吡格雷双抗与阿司匹林单药治疗急性轻度缺血性卒中及高危短暂性脑缺血发作的比较:系统综述及meta分析显示文摘目的为了评估对于急性轻度缺血性卒中及短暂性脑缺血发作(TIA)患者应用联合阿司匹林及氯吡格雷双抗治疗,相较于单用阿司匹林,预防血栓再发及出血事件的有效性及安全性。研究设计对随机、安慰剂对照研究进行系统综述及meta分析。 | Qiukui Hao Malavika Tampi Martin O' Donnell Farid Foroutan Reed AC Siemieniuk Gordon Guyatt 李洁(译) 毛晨晖(校) | 2019 | 英国医学杂志中文版2019，22，5： | 5 |
| 4 | Predictors of serological cure and serofast state after treatment in HIV-negative persons with early syphilis显示文摘 | Sena AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，11： | 1 |
| 5 | Polyhydroxybutyrateco-hydroxyvalerate structures loaded with adipose stemcells promote skin healing with reduced scarring显示文摘 | Zonari A Martins TM Paula AC | 2015 | ActaBiomater2015，17，： | 1 |
| 6 | Inhibition of platelets and tumor cell adhesion by the disintegrin domain of human ADAM9 to collagen I under dynamic flow conditions 显示文摘 | Cominetti MR Martin AC Ribeiro JU | 2009 | Biochimie2009，91，8： | 1 |
| 7 | Moter neuron degeneration after sciatic nerve avulsion in adult evolves with oxidative stress and is apoptosis显示文摘 | Martin IJ Kaiser A price AC | 1999 | J Neurobiol1999，40，2： | 1 |
| 8 | Polymorphisms in the NQO1,GSTT and GSTM genes are associated with coronary heart disease and biomarkers of oxidative stress显示文摘 | Martin NJ Collier AC Bowen LD | 2009 | Mutat Res2009，674，12： | 1 |
| 9 | Parkinson′s disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death显示文摘 | Martin LJ Pan Y Price AC | 2006 | J Neurosci2006，26，1： | 1 |
| 10 | Control of effector CD8+ T cell function by the transcription factor Eomesodermin 显示文摘 | Pearce EL Mullen AC Martins GA | 2003 | Science2003，302，： | 1 |
| 11 | Hygroscopic expan-sion and solubility of composite restoratives 显示文摘 | Martin N Jedynakiewicz NM Fisher AC | 2003 | Dent Mater2003，，： | 1 |
| 12 | TNF - re- lated weak inducer of apoptosis (TWEAK) promotes kidney fi- brosis and Ras- dependent proliferation of cultured renal fibre- blast显示文摘 | Ucero AC Benito - Martin A Fuentes - Calvo I | 2013 | Biochim Biophys Acta2013，1832，10： | 1 |
| 13 | Control of effector CD8 T cell function by the transcription factor Eomesodermin显示文摘 | Pearce EL Mullan AC Martins GA | 2003 | Science2003，302，： | 1 |
| 14 | Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular man显示文摘 | Booth RF Martin JF Honey AC | 1989 | Atherosclerosis1989，76，23： | 1 |
| 15 | Predictors of serological cure and serofast state after treatment in HIV-negative persons with early syphilis 显示文摘 | Seiia AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，1： | 1 |
| 16 | Motor neuron degeneration after sciatic nerve avulsion in adult evolves with oxidative stress and is apoptosis显示文摘 | Martin IJ Kaiser A Price AC | 1999 | J Neurobiol1999，40，2： | 1 |
| 17 | Predictors of serological cure and Serofast State after treatment in HIV-negative persons with early syphilis显示文摘 | Se(n)a AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，11： | 1 |
| 18 | Interaction of rapid nongenomic cardiovascular aldosterone efects with the adronergic system 显示文摘 | Schmidt EMW Georgens AC Martin N | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 19 | A national survey of terrorism pre- paredness training among pediatric, family practice, and emergency medicine programs 显示文摘 | Martin SD Bush AC Lynch JA | 2006 | Pediatrics2006，118，3： | 1 |
| 20 | TNF - re- lated weak inducer of apoptosis (TWEAK) promotes kidney fi- brosis and Ras - dependent proliferation of cultured renal fibro- blast显示文摘 | Ucero AC Benito - Martin A Fuentes - Cairo I | 2013 | Biochim Biophys Acta2013，1832，10： | 1 |
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