维普中文期刊产品整合服务
43篇 您的检索式:作者名="ABRAMS T J"
    题名 作者 年代 出处 被引量
1Circulating histones are mediators of traumaassociated lung injury 显示文摘Abrams S T Zhang N Manson J 2013Am J Respir Crit Care Med2013,187,2:1
2成人2型糖尿病不同筛查及预防策略成本效益分析显示文摘目的 比较针对2型糖尿病预防及治疗的4种筛查策略及随后予以的干预措施:(a)筛查2型糖尿病患者使其能接受早期检查及治疗,(b)筛查2型糖尿病和糖耐量受损患者,对糖耐量受损的人群予以生活方式干预以延缓或预防糖尿病的发生,(c)同(b)但予以药物干预措施,(d)不筛查。 设计 成本效益决策分析建立在对概率的发展和评估基础上,是从筛查到死亡的综合性经济决策分析模型。 研究对象 一组假设人群,筛查时年龄45岁,高于平均糖尿病风险水平。 数据来源 电子书目数据库收录的已发表的临床试验和流行病学研究;补充数据分别来自英国和威尔士健康统计署、风险筛查(STAR)研究和ADDITION研究的Leicester部分。 方法 建立一种决策树/Markov混合模型,以模拟每一种筛查策略的长期效用,包括临床和成本效益终点。该模型假设水平跨度为50年时间,其成本效益折损率为3.5%。采用敏感度分析以验证模型假设及确定哪种模型数据输入对结果的影响最大。 结果 与不筛查策略比较,筛查2型糖尿病、筛查糖尿病和糖耐量受损并予以生活方式干预、筛查糖尿病和糖耐量受损并予以药物干预治疗3种策略,每获得一个质量调整生命年(QALY)估计所需成本分别为(每年成本效益贴现率为3.5%)14150英镑(17560欧元;27860美元)、6242英镑和7023英镑。在支付意愿阈值为20000英镑时,各主动筛查策略通过干预产生的成本效益概率分别为49%,93%和85%。 结论 对年龄45岁、高于平均风险水平的人群进行2型糖尿病和糖耐量受损的筛查,并对糖耐量受损人群予以适当的干预似乎具有很好的成本效益。单独筛查糖尿病而不对糖耐量受损人群予以干预的策略具有的成本效益仍不确定,需要进一步研究确定早期检测糖尿病的作用。Clare L Gillies Paul C Lambert Keith R Abrams Alex J Sutton Nicola J Cooper Ron T Hsu Melanie J Davies Kamlesh Khunti 张晓梅(译) 纪立农(校) 2008英国医学杂志中文版2008,11,5:1
3Metabolism of ( + )-abscisic acidto ( + )-7'-hydroxyabscisic acid by bromegrass cell cultures显示文摘HAMPSON C R REANEY M J T ABRAMS G D 1992Phytochemistry1992,31,:1
4Ultrasound-guided obturator nerve block:an interfascial injection approach without nerve stimulation显示文摘SINHA S K ABRAMS J H HOULE T T 2009Reg Anesth Pain Med2009,34,3:1
5Sunitinib inhibits KIT and platelet-derived growth fac- tor receptor in preclinical models of human small cell lung cancer 显示文摘ABRAMS T J LEE L B MURRAY L J 2003Mol Cancer Ther2003,2,:1
6Coronary risk factors and their modification lipids, smoking, hypertension, estrogen, and the elderly显示文摘ABRAMS J VELA B S COULTAS D t 1995Curt Probl Cardiol1995,20,8:1
7The risk of colorectal cancer in ulcerative colitis: a meta-analysis显示文摘EADEN J A ABRAMS K R MAYBERRY T F 2001Gut2001,48,:1
8Coral Reef Death During the 1997 Indian Ocean Dipole Linked to Indonesian Wildfires 显示文摘Abram N J Gagan M K McCulloch M T 2003Science2003,301,:1
9SU11248 inhibits KIT and platelet-derived growth factor receptor 13 in preclinical models of human small cell lung cancer显示文摘Abrams T J Lee L B Murray L J 2003Mol Cancer Ther2003,2,5:1
10A phase Ⅱ study of external irradiation and weekly palitaxel for non-metastatic ,unresectable pancreatic cancer:A preliminary report of RTOG protocol 98-12显示文摘Rich T Haris J Abrams R 2001Int J Radiat Oncol Biol Phya2001,51,:1
11A new non-invasive method to assess synovitis severity in relation to symptoms andcartilage volume loss in knee osteoarthritis patients using MRI显示文摘Pelietier J P Raynauld T P Abram F 2008OARS2008,16,3:1
12The risk of colorectal cancer in ulcerative colitis: a meta-analysis显示文摘EADEN J A ABRAMS K R MAYBERRY T F 2001Gut2001,48,:1
13Analysis of collagen status in premenopausal nulliparous women with genuine stress incontinence显示文摘KEANE D P SIMS T J ABRAMS P 1997Br J Obstet Gynaecol1997,104,9:1
14The role of size-speeifie predation in the evolution and diversification of prey life histories显示文摘Day T Abrams P A Chase J M 2002Evolu- tion2002,56,:1
15Prospective quality initiative to maximize dysphagia screening reduces hospital-acquired pneumonia prevalence in patients with stroke显示文摘Lee T W Abram J Fullerton A 2013A Journal of Cerebral Circulation2013,44,11:1
16Decreasing the local anesthetic volume from 20 to 10 ml for ultra- sound-guided intersealene block at the crieoid level does not reduce the incidence of hemidiaphragmatic paresis 显示文摘Sinha S K Abrams J H Barnett J T 2011Reg Anesth Pain Med2011,36,1:1
17Analysis of collagen status in premenopausal nulliparous women with genuine stress incontinence显示文摘Keane D P Sims T J Abrams P 1997Br J Obstet Gynaecol1997,104,9:1
18SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo显示文摘O'Farrell A M Abrams T J Yuen H A 2003Blood2003,101,9:1
19Phase Ⅰ study of cetuximab,irinotecan,and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer显示文摘Meyerhardt J A Ancukiewicz M Abrams T A 0,,6:1
20Characteriza- tion of the porosity in TRISO coated fuel particles and its effect on the relative thermal diffusivity显示文摘Bari K Osarinmwian C Abram T J 2013Nuclear Engineering and Design2013,265,:1
返回顶部 每页显示:
共3页 首页 上一页 第1页 下一页 末页 /3 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费