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| 1 | Immunological detection of activated platelets of clinical disorders显示文摘 | Abrams C Shattil S L | 1991 | Thromb Haemost1991，65，： | 1 |
| 2 | Diuretics:1,2,4-Benzothiadiazine-1,1-Dioxides显示文摘 | NoveUo F C Bell S C Abram s E L A | 1960 | J Org Chem1960，25，6： | 1 |
| 3 | Effects of Synthetic Micro- and Nano-structured Surfaces on Cell Behavior 显示文摘 | Flemming R G Murphy C J Abrams G A Goodman S L and Nealey P F | 1999 | Biomaterials1999，20，6： | 1 |
| 4 | Phar- macological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance:systematic review and meta-analysis显示文摘 | Clare L Gillies Keith R Abrams Paul C Lambert | 2007 | BMJ2007，334，： | 1 |
| 5 | 成人2型糖尿病不同筛查及预防策略成本效益分析显示文摘目的 比较针对2型糖尿病预防及治疗的4种筛查策略及随后予以的干预措施:(a)筛查2型糖尿病患者使其能接受早期检查及治疗,(b)筛查2型糖尿病和糖耐量受损患者,对糖耐量受损的人群予以生活方式干预以延缓或预防糖尿病的发生,(c)同(b)但予以药物干预措施,(d)不筛查。
设计 成本效益决策分析建立在对概率的发展和评估基础上,是从筛查到死亡的综合性经济决策分析模型。
研究对象 一组假设人群,筛查时年龄45岁,高于平均糖尿病风险水平。
数据来源 电子书目数据库收录的已发表的临床试验和流行病学研究;补充数据分别来自英国和威尔士健康统计署、风险筛查(STAR)研究和ADDITION研究的Leicester部分。
方法 建立一种决策树/Markov混合模型,以模拟每一种筛查策略的长期效用,包括临床和成本效益终点。该模型假设水平跨度为50年时间,其成本效益折损率为3.5%。采用敏感度分析以验证模型假设及确定哪种模型数据输入对结果的影响最大。
结果 与不筛查策略比较,筛查2型糖尿病、筛查糖尿病和糖耐量受损并予以生活方式干预、筛查糖尿病和糖耐量受损并予以药物干预治疗3种策略,每获得一个质量调整生命年(QALY)估计所需成本分别为(每年成本效益贴现率为3.5%)14150英镑(17560欧元;27860美元)、6242英镑和7023英镑。在支付意愿阈值为20000英镑时,各主动筛查策略通过干预产生的成本效益概率分别为49%,93%和85%。
结论 对年龄45岁、高于平均风险水平的人群进行2型糖尿病和糖耐量受损的筛查,并对糖耐量受损人群予以适当的干预似乎具有很好的成本效益。单独筛查糖尿病而不对糖耐量受损人群予以干预的策略具有的成本效益仍不确定,需要进一步研究确定早期检测糖尿病的作用。 | Clare L Gillies Paul C Lambert Keith R Abrams Alex J Sutton Nicola J Cooper Ron T Hsu Melanie J Davies Kamlesh Khunti 张晓梅(译) 纪立农(校) | 2008 | 英国医学杂志中文版2008，11，5： | 1 |
| 6 | African swine fever virus protein A238L interacts with the cellular phosphatase calcineurin via a binding domain similar to that of NFAT显示文摘 | Miskin J E Abrams C C Dixon L K | 2000 | J Virol2000，74，20： | 1 |
| 7 | Degenerate four-wave mixing in absorbing media显示文摘 | ABRAMS R L LIND R C | 1978 | Opt Lett1978，2，4： | 1 |
| 8 | African swine fever virus proteins involved in evading host defenee systems显示文摘 | Dixon L K Abrams C C Bowick G | 2004 | Vet Immunol Immunopathol2004，100，34： | 1 |
| 9 | Comparison of the ef- ficacy, safety, and tolerability of propiverine and oxybutynin for the treatment of overactive bladder syndrome 显示文摘 | Abrams P Cardozo L Chapple C | 2006 | Int J Urol2006，13，6： | 1 |
| 10 | Effects of freezing on mechanical properties of rat skin显示文摘 | Foutz T L Stone E A Abrams C F | 1992 | Am J Vet Res1992，53，： | 1 |
| 11 | Pancreaticoduodenectomy for pancreatic adenocarcinoma:postoperative adjuvant chemoradiation improves survival:a prospective,single institution experience显示文摘 | Yeo C Abrams R Grochow L Sohn T Ord S Hruban R | | 0，，： | 1 |
| 12 | Nurturing interpersonal trust in knowledge sharing networks 显示文摘 | Abrams L C Cross R Lesser E Levin D Z | 2003 | Academy of Management Executive2003，17，： | 1 |
| 13 | Nurturing interpersonal trust in knowledge-sharing networks 显示文摘 | ABRAMS L C CROSS R LESSER E | 2003 | The Academy of Management Executive2003，17，4： | 1 |
| 14 | Selective synthe- sis of dimethylamine over small-pore zeolites: catalytic selectivity and sorption behavior 显示文摘 | Abrams L Miehael K J Sonnichsen G C | 1989 | J Catal1989，115，2： | 1 |
| 15 | A ten-year record of aboveground biomass in a Kansas tallgrass prairie: effects of fire and topographic position显示文摘 | ABRAMS M D KNAPP A K HULBER'F L C | 1986 | American Journal of Botany1986，73，10： | 1 |
| 16 | Nurturing Interpersonal Trust in Knowledge-Sharing Networks显示文摘 | Abrams L C | 2003 | The Academy of Management Executive2003，17，4： | 1 |
| 17 | Deletion of virulence associated genes from attenuated African swine fever virus isolate OUR T88/3 decreases its ability to protect against challenge with virulent virus显示文摘 | Abrams C C Goatley L Fishbourne E | 2013 | Virology2013，443，： | 1 |
| 18 | Nurturing interpe- rsonal trust in knowledge-sharing networks显示文摘 | Abrams L C Cross R Lesser E | 2003 | Academy of Management Executive2003，17，4： | 1 |
| 19 | Mapping hydrothermally altered rocks at Cuprite, Nevada, using the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER), a new satellite- imaging system显示文摘 | Rowan L C Hook S J Abrams M J | 2003 | Economic Geology and the Bulletin of the Society of Economic Geologists2003，98，5： | 1 |
| 20 | Mapping hydrothermally altered rocks at CUPRITE} NEVADA,using the Advanced Spacebome Ther- mal Emission and Reflection Radiometer(ASTER),a new satellite- imaging system显示文摘 | Rowan L C Hook S Abrams MJ | 2003 | Economic Geology2003，，98： | 1 |
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