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| 1 | Pam3CSK4 enhances adaptive immune responses to recombinant Mycobacterium bovis bacille Calmette-Guérin expressing Plasmodium falciparum C-terminus merozoite surface protein-1显示文摘Objective: To determine the effects of toll-like receptor 2(TLR-2) agonist, Pam3 CSK4, on cellular and humoral immune response against recombinant Mycobacterium bovis bacille Calmette-Guérin(rBCG) expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum.Methods: Six groups of mice(n=6 per group) received intraperitoneal phosphate buffered saline T80(PBS-T80), BCG or rBCG in the presence or absence of Pam3 CSK4. Enzymelinked immunosorbent assay was carried out to measure serum total IgG, IgG1, IgG2 a, and Ig G2 b production. Spleens were also harvested and splenocytes were co-cultured with rBCG antigen for in vitro determination of IL-4 and IFN-γ via enzyme-linked immunosorbent assay.Results: The production of total IgG and the isotype IgG1, IgG2 a and IgG2 b was significantly higher in rBCG-immunised mice than in the BCG and PBS-T80-immunised mice, and Pam3 CSK4 further enhanced their productions. A similar pattern was also observed in IFN-γ production. Moreover, there was no significant difference in IL-4 production in all groups either in the presence or absence of Pam3 CSK4.Conclusions: We present evidence of the adjuvant effects of TLR-2 agonist in enhancing the production of total IgG, IgG1, IgG2 a, IgG2 b, as well as IFN-γ in response to rBCG. However, the presence or absence of Pam3 CSK4 had no effect on IL-4 production. | Mohamed H Abdikarim Muhammad A Abbas Munirah N Zakaria Robaiza Zakaria Rapeah Suppian | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，7： | 3 |
| 2 | MHD flow and mass transfer of an upper-convected Maxwell fluid past a porous shrirddng sheet with chemical reaction species显示文摘 | Hayat T Abbas Z Ali N | 2008 | Phy Lett A2008，372，26： | 1 |
| 3 | Correlation of three immunohistochemically detected markers of netrroendncrine differentiation with clinical predictors of disease lbrogression in prostate cancer显示文摘 | Ather MH Abbas F Faruqui N | 2008 | BMC Uro2008，8，： | 1 |
| 4 | Application of radial basis function network for the modeling and simulation of turbogenerator 显示文摘 | Mohsen H Abbas R Leila N | 2013 | Journal of Advances in Information Technology2013，4，2： | 1 |
| 5 | Long-term me- salamine maintenance in ulcerative colitis:which is more impor- tant adherence or daily dose显示文摘 | Khan N Abbas AM Koleva YN | 2013 | Inflamm Bowel Dis2013，19，6： | 1 |
| 6 | Predictors of remission of type 2 diabetes mellitus after laparoscopic gastric banding and bypass显示文摘 | Hamza N Abbas MH Darwish A | 2011 | Surg Obes Relat Dis2011，7，6： | 1 |
| 7 | A review on current research trends in electrical discharge machining (EDM)显示文摘 | Abbas N M Solomon D G Bahari Md F | | 0，，7： | 1 |
| 8 | A review of Parry-Romberg syndrome显示文摘 | El-Kehdy J Abbas O Rubeiz N | 2012 | J Am Acad Dermatol2012，67，4： | 1 |
| 9 | Evolution of oxide scale on a Ni- Mo-Cr alloy at 900 ~C 显示文摘 | U1-Hamid A Mohammed A I A1-Jaroudi S S Tawancy H M Abbas N M | 2007 | Materials Characterization2007，58，1： | 1 |
| 10 | Knowledge, attitudes and practices regarding tuberculosis among immigrants of Somalian ethnic origin in London: a cross-sectional study 显示文摘 | Shetty N Shemko M Abbas A | 2004 | Commun Dis Public Health2004，7，1： | 1 |
| 11 | Novel mesoporous silica supported ZnO adsorbents for the desulphurization of biogas at low temperatures显示文摘 | Hussain M Abbas N Fino D | 2012 | Chemical Engineering Journal2012，188，： | 1 |
| 12 | Resectability rates in locally advanced esophageal carcinoma following neo-adjuvant chemoradiotherapy显示文摘 | Abbas A Ali N Hameed S | 2003 | J Ayub Med Coll Abbottabad2003，15，4： | 1 |
| 13 | The effect of brady- kinin and its antagonist on survival time after coronary artery occlusion in hypertensive rats 显示文摘 | ABBAS S A SHARMA J N YUSOF A P | 1999 | hnmunopharmacology1999，44，： | 1 |
| 14 | A review on current researeh trends in electrical discharge machining (EDM) 显示文摘 | Abbas N M Solomon D G Fuad Bahari Md | 2007 | International Journal of Machine Tools and Manufacture2007，47，78： | 1 |
| 15 | Tumor necrosis factor gene polymorphism resultsin high TNF levelin sepsis and septic shock 显示文摘 | Kothari N Bogra J Abbas H | 2013 | Cytokine2013，61，2： | 1 |
| 16 | The scorpion toxin amm viii induces pain hypersensitivity through gain- of - function of ttx - sensitive na ( + ) channels 显示文摘 | Abbas N Gaudioso - Tyzra C Bonnet C | 2013 | Pain2013，154，： | 1 |
| 17 | Mechanism of Carburization of High-Temperature Alloys 显示文摘 | Tawancy H M Abbas N M | 1992 | Journal of Materials Science1992，27，： | 1 |
| 18 | Successful Treatment of Hepatitis B Virus ( HBV)-associated Membranoproiiferative Glomerulonephritis (MPGN) with Alpha Interferon 显示文摘 | Abbas N A Pitt M A Green A T | 1999 | Nephrol Dial Transplant1999，14，： | 1 |
| 19 | A role for TonB1 in biofilm formation and quorum sensing in Pseudomonas aerugi- nosa 显示文摘 | Abbas A Adams C Scully N | 2007 | FEMS Microbiol Lett2007，274，2： | 1 |
| 20 | Effect of bradykinin and its antagonist on survival time after coronary artery oc- clusion in rats显示文摘 | ABBAS S A SHARMA J N YUSOF A P | 1999 | Gen Pharmacol1999，33，： | 1 |
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