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| 1 | The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment显示文摘 | Ziad S.Nasreddine Natalie A.Phillips ValérieBédirian SimonCharbonneau VictorWhitehead IsabelleCollin Jeffrey L.Cummings HowardChertkow | 2005 | Journal of the American Geriatrics Society2005，，4： | 12 |
| 2 | Managing for stakeholders, stakeholder utility functions, and competitive advantage显示文摘 | Jeffrey S.Harrison Douglas A.Bosse Robert A.Phillips | 2009 | Strat. Mgmt. J2009，，1： | 2 |
| 3 | The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment显示文摘 | Ziad S.Nasreddine Natalie A.Phillips ValérieBédirian SimonCharbonneau VictorWhitehead IsabelleCollin Jeffrey L.Cummings HowardChertkow | 2005 | Journal of the American Geriatrics Society2005，，4： | 1 |
| 4 | The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment显示文摘 | Ziad S.Nasreddine Natalie A.Phillips ValérieBédirian SimonCharbonneau VictorWhitehead IsabelleCollin Jeffrey L.Cummings HowardChertkow | 2005 | Journal of the American Geriatrics Society2005，，4： | 1 |
| 5 | The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment显示文摘 | Ziad S.Nasreddine Natalie A.Phillips ValérieBédirian SimonCharbonneau VictorWhitehead IsabelleCollin Jeffrey L.Cummings HowardChertkow | 2005 | Journal of the American Geriatrics Society2005，，4： | 1 |
| 6 | Prazosin:a potential new management tool for iatrogenic autonomic dysreflexia in individuals with spinal cord injury?显示文摘Spinal cord injury(SCI)is a devastating condition that not only results in a loss of motor functions but also severe autonomic dysfunctions(Krassioukov and Claydon,2006).Autonomic dysreflexia(AD)is a life threatening episode of transient hypertension that occurs up to 30x/day(11x/day | Mei M.Z.Zheng Aaron A.Phillips Stacy L.Elliott Andrei V.Krassioukov | 2015 | Neural Regeneration Research2015，10，4： | 1 |
| 7 | The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment显示文摘 | Ziad S.Nasreddine Natalie A.Phillips ValérieBédirian SimonCharbonneau VictorWhitehead IsabelleCollin Jeffrey L.Cummings HowardChertkow | 2005 | Journal of the American Geriatrics Society2005，，4： | 1 |
| 8 | Genetic dissection of climacteric fruit ripening in a melon population segregating for ripening behavior显示文摘Melon is as an alternative model to understand fruit ripening due to the coexistence of climacteric and non-climacteric varieties within the same species,allowing the study of the processes that regulate this complex trait with genetic approaches.We phenotyped a population of recombinant inbred lines(RILs),obtained by crossing a climacteric(Védrantais,cantalupensis type)and a non-climcteric variety(Piel de Sapo T111,inodorus type),for traits related to climacteric maturation and ethylene production.Individuals in the RIL population exhibited various combinations of phenotypes that differed in the amount of ethylene produced,the early onset of ethylene production,and other phenotypes associated with ripening.We characterized a major QTL on chromosome 8,ETHQV8.1,which is sufficient to activate climacteric ripening,and other minor QTLs that may modulate the climacteric response.The ETHQV8.1 allele was validated by using two reciprocal introgression line populations generated by crossing Védrantais and Piel de Sapo and analyzing the ETHQV8.1 region in each of the genetic backgrounds.A Genome-wide association study(GWAS)using 211 accessions of the ssp.melo further identified two regions on chromosome 8 associated with the production of aromas,one of these regions overlapping with the 154.1 kb interval containing ETHQV8.1.The ETHQV8.1 region contains several candidate genes that may be related to fruit ripening.This work sheds light into the regulation mechanisms of a complex trait such as fruit ripening. | Lara Pereira Miguel Santo Domingo Valentino Ruggieri Jason Argyris Michael A.Phillips Guangwei Zhao Qun Lian Yongyang Xu Yuhua He Sanwen Huang Marta Pujol Jordi Garcia-Mas | 2020 | Horticulture Research2020，7，1： | 1 |
| 9 | Patient-centric dose equivalency pilot study of incobotulinumtoxin a(xeomin)vs.abobotulinumtoxin a(dysport)in the treatment of glabellar frown lines显示文摘Aim:Incobotulinumtoxin A(xeomin)has been proposed as an alternative to abobotulinumtoxin A(dysport)and onabotulinumtoxin A(Botox)in the treatment of glabellar frown lines.A recent study is comparing abobotulinumtoxin A and onabotulinumtoxin A revealed equivalent efficacy with a dose conversion ratio of 2.5:1.We sought to establish effectiveness and dosing equivalency of incobotulinumtoxin A vs.abobotulinumtoxin A.Methods:Inclusion criteria for this pilot study included patients of a single surgeon(LAC)who had previously received a constant dose of abobotulinumtoxin A over at least four consecutive treatment sessions for the previous 12 months to achieve an 85-90%elimination of dynamic glabellar frown lines.The primary outcome sought dose comparison between established maintenance abobotulinumtoxin A dosing and incobotulinumtoxin A first-time dosing.A 2:1 conversion(abobotulinumtoxin A:incobotulinumtoxin A)was chosen in most patients.Secondary outcomes were patient-reported onset of effect,physician-assessed effect at 10-12 weeks,pain associated with administration,and patient perceived need for re-treatment at 2 weeks.Results:A total of 32 subjects were included.The mean dose of incobotulinumtoxin A was 17.1 units(±6.1,the median dose 20 units).The mean dose of abobotulinumtoxin A was 27.6(±11.7,the median dose 27.5 units).The mean difference in treatment units was 10.5(95%confidence interval,P<0.001).Among 30 patients who reported effect onset,the median was 8.5 days,with a range of 1-14.At 10-12 weeks,muscle paralysis was assessed to be 69.2%(±27.3),vs.90.3%(±1.8)with abobotulinumtoxin A(P<0.001).The majority of patients rated pain of administration as equal or greater to that of abobotulinumtoxin A(63%and 22%,respectively).Three patients(9%)required re-treatment at 2 weeks with abobotulinumtoxin A due to lack of effective treatment with incobotulinumtoxin A.Abobotulinumtoxin A re-treatment was chosen by the patient.Conclusion:We found incobotulinumtoxin A at 17.1(±6.1)units to be less effective than abobotulinumtoxin A at 27.6(±11.7)units in the treatment of glabellar frown lines at 10-12 weeks postadministration.Dosing was less predictable than dosing associated with abobotulinumtoxin A treatment.Larger,randomized controlled trials are indicated to further delineate these differences and to clarify whether this difference from previously published incobotulinumtoxin A dosing may have been due to the small sample size. | Jonathan Bank Nicole A.Phillips Laurie A.Casas | 2015 | Plastic and Aesthetic Research2015，2，1： | 0 |
| 10 | Silk fibroin as an additive for cell-free protein synthesis显示文摘Cell-free systems contain many proteins and metabolites required for complex functions such as transcription and translation or multi-step metabolic conversions.Research into expanding the delivery of these systems by drying or by embedding into other materials is enabling new applications in sensing,point-of-need manufacturing,and responsive materials.Meanwhile,silk fibroin from the silk worm,Bombyx mori,has received attention as a protective additive for dried enzyme formulations and as a material to build biocompatible hydrogels for controlled localization or delivery of biomolecular cargoes.In this work,we explore the effects of silk fibroin as an additive in cell-free protein synthesis(CFPS)reactions.Impacts of silk fibroin on CFPS activity and stability after drying,as well as the potential for incorporation of CFPS into hydrogels of crosslinked silk fibroin are assessed.We find that simple addition of silk fibroin increased productivity of the CFPS reactions by up to 42%,which we attribute to macromolecular crowding effects.However,we did not find evidence that silk fibroin provides a protective effects after drying as previously described for purified enzymes.Further,the enzymatic crosslinking transformations of silk fibroin typically used to form hydrogels are inhibited in the presence of the CFPS reaction mixture.Crosslinking attempts did not impact CFPS activity,but did yield localized protein aggregates rather than a hydrogel.We discuss the mechanisms at play in these results and how the silk fibroin-CFPS system might be improved for the design of cell-free devices. | Marilyn S.Lee Chia-Suei Hung Daniel A.Phillips Chelsea C.Buck Maneesh K.Gupta Matthew W.Lux | 2020 | Synthetic and Systems Biotechnology2020，5，3： | 0 |
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