|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 放射性束辐照生物学效应及相关生物物理机理显示文摘介绍了β缓发粒子衰变放射性束9C辐照处于不同贯穿深度上人类唾液腺细胞的深度存活效应。与稳定的12C束流相比,放射性9C束流在其Bragg峰区附近展示了增强的生物学效应,即细胞的致死效率明显增强。探讨了放射性束9C在其Bragg峰区展示增强生物学效应的生物物理机制,并介绍了利用另一种放射性束8B进行辐照生物学效应研究的新进展。最后,提出了一些利用放射性束可进行的辐照生物学效应前沿研究。 | 李强 Y.Furusawa A.Kitagawa M.Kanazawa 金晓东 戴中颖 | 2007 | 原子核物理评论2007，24，2： | 5 |
| 2 | Production of radioactive ~9C ion beam and its optimization显示文摘To explore the medical use of a radioactive 9C-ion beam in tumor treatment, which is a double radiation source coming from the external beam itself and the delayed particles emitted internally, some physical experiments are performed at the Secondary Beam Line (SBL) of Heavy Ion Medical Accelerator, Chiba (HIMAC) in Japan be- fore radiobiological research for exhibiting therapeutic value of the 9C beam. Intention of the experiments is for pro- ducing a radioactive 9C-ion beam with higher production rate and purity by means of optimizing the beam line pa- rameters. Finally, a produced 9C beam with the production rate of 9.07×10-6 and purity of 82.88% at full momentum acceptance has been obtained under the optimal conditions of 40 mm-thick beryllium target and 10 mm-thick alumi- num degrader. Both momentum distribution and contaminations for the produced 9C beam under the optimal condi- tions are measured. In order to execute further biological experiments of the 9C beam project, a uniform irradiation field is made with the wobbling magnets and its homogeneity is up to 93.8% inside central area of 20mm in diameter. | WEIZeng-Quan LIQiang A.KITAGAWA T.KANAI M.KANAZAWA E.URAKABE XIEHong-Mei ZHOUGuang-Ming | 2005 | Nuclear Science and Techniques2005，16，2： | 3 |
| 3 | 放射性离子束^(9)C的细胞生物学效应显示文摘首先介绍了重离子束治癌的特点及当前的技术进步, 着重讨论了放射性离子束(RIB)在肿瘤治疗上增添的优势, 详细叙述了在日本放射医学综合研究所(NIRS)重离子医用加速器(HIMAC)上旨在肿瘤治疗的放射性离子束 C 的实验研究, 包括束流产生、参数优化、深度物理剂量分布、细胞辐照后的存 9活效应以及 C 和 C 束的相对生物效率(RBE)比较. 最终结果: 在40 mm 厚铍靶、10 mm 厚铝降能器、 9 125%动量接收度时, 采用 430 MeV/u、1.8×109 粒子/s 的初试束 C, 得到的 C 束的产生率为 9.07×10?6, 12 9纯度为 82.88%, 采用点扫描技术时, 在直径为 10 mm 的中心面积内, 可获得均匀度为 89.6%的辐照场,这时在入口处的剂量率为0.5Gy/h. 在Bragg峰附近范围内的细胞存活实验中, C束的平均RBE为5.28, 9而 C 束的平均 RBE 为 2.93, C 束的 RBE 要比 C 束的高1.8 倍, 这显示 C 束在 Bragg 峰附近范围内, 12 9 12 9对细胞的杀伤力要比 C 强, 在肿瘤治疗上会更有效. | 卫增泉 李强 A.Kitagawa T.Kanai M.Kanazawa Y.Furusawa E.Urakabe 颉红梅 周光明 | 2005 | 科学通报2005，50，5： | 2 |
| 4 | Biological effects of radioactive ~9C-ion beams on cells显示文摘The distinguishing feature and current technique progress of tumor treatment with heavy-ion beams is introduced in the paper. Additional superiority to tumor treatment from a radioactive ion beam (RIB) is emphatically discussed. The experimental research of the radioactive 9C-ion beams aimed at tumor treatment at Heavy Ion Medical Accelerator in Chiba (HIMAC), National Institute of Radiological Sciences (NIRS), Japan is described in detail, La-eluding production of the beams, optimization of parameters, distribution of depth dose, survival effect of cell and comparison of RBE between 9C- and 12C-beams. Results show that under 40 mm thick Beryllium target and 10 mm thick aluminum degrader at full (5%) momentum acceptance, the production rate and purity of the produced 9C-beams are 9.07×10-6 and 82.88% respectively with the primary 12C-beams of 430 MeV/u and 1.8×109 pps. A uniform irradiation field with homogeneity up to 89.6% inside central area 10 mm in diameter is obtained by using spot scanning. In this case, the dose rate at the entrance is 0.5 Gy/h. In survival experiment of cells, the average relative biological effectiveness (RBE) of 9C-beams is 5.28 and 2.93 for 12C-beams in the region around Bragg peak. The RBE of 9C-beams is 1.8 times higher than that of 12C-beams. It indicates that cell-killing efficiency of 9C-beams is stronger than that of 12C-beams. 9C-beams are more efficacious for tumor treatment than 12C-beams. | WEIZengquan LIQiang A.Kitagawa T.Kanai M.Kanazawa Y.Furusawa E.Urakabe XIEHongmei ZHOUGuangming | 2005 | Chinese Science Bulletin2005，50，11： | 2 |
| 5 | NIRS的ECR离子源现状(英文)显示文摘Four ECR ion sources have been operated in National Institute of Radiological Sciences(NIRS). Two ECR ion sources supply various ion species for the Heavy Ion Medical Accelerator in Chiba(HIMAC). The 10GHz NIRS-ECR ion source mainly produces C2+ ions for the heavy-ion therapy.Ions of Si,Ar,Fe,Kr and Xe are usually produced by the 18GHz NIRS-HEC ion source for physical and biological experiments.The other two compact ECR ion sources with all permanent magnet configuration have been developed for the new generation carbon therapy facility.One of these,the Kei-source,is a prototype which has been installed to the NIRS-930 cyclotron for axial injection.The other source,Kei2-source,is a demonstration source and utilized for the new generation Linac.In addition,both Kei sources have been used to study fundamental properties. In this paper,present status of the ion sources and recent developments are reported. | M.Muramatsu A.Kitagawa Y.Iwata K.Yamamoto H.Ogawa S.Hojo Y.Sakamoto T.Honma W.Takasugi M.Wakaisami Y.Yoshida T.Kubo Y.Kato S.Biri A.G.Drentje | 2007 | Chinese Physics C2007，31，S1： | 0 |
| 6 | Kei2 ECR离子源C4+、C5+束流的最佳结果(英文)显示文摘With the prototype ECR ion source for the next carbon therapy facility in Japan a new series of measurements has been performed in order(a)to find the highest beam currents of C4+ ions,and(b)to study the effect of'special'gas-mixing by using a chemical compound as a feed gas.An isotopic effect has been found in a previous experiment:with deuterated methane(CD4 gas) the C5+ beam currents are about 10% higher than with regular methane(CH4 gas).For butane gases(C4D10 and C4H10 respectively)the isotopic effect for C5+ production is even stronger(>15%).For production of C4+ ions the isotopic effect appears to be absent.It turns out that the relative amount of carbon is much more important:acetylene gives 15% higher C4+ current than butane,which in turn gives about 10% higher C4+ ion currents than methane. | A.G.Drentje M.Muramatsu A.Kitagawa | 2007 | Chinese Physics C2007，31，S1： | 0 |
| 7 | ^(28)P的磁矩测量显示文摘β放射性核素^28P的单质子分离能为2.065MeV,最外一个质子处在2s1/2轨道。目前无论从截面测量实验还是理论研究结果,均表明^28P有质子晕结构。但到现在为止,还没有人给出^28P核素的磁矩和电四极矩值。而磁矩和电四极矩值在确定晕结构核方面是非常重要的实验数据。 | 周冬梅 郑永男 袁大庆 左翼 刘猛 范平 M.Mihara M Fukuda K.Matsuta T.Minamisono T.Nagatomo S.Momota A.Kitagawa T.Izumikawa 朱升云 | 2006 | 中国原子能科学研究院年报2006，，1： | 0 |
| 8 | The ab initio Calculation of Electric Field Gradient at the Site of P Impurity in α-Al_(3)O_(2)显示文摘An ab initio calculation of the electric-field gradient(EFG)at the site of a phosphorous impurity substituting an Al atom in α-Al_(3)O_(2) is carried out using the WIEN2k code with the full-potential linearized augmented plane wave plus local orbital method(LAPW+lo)in the frame of density functional theory.The atomic lattice relaxations caused by the implanted impurities were calculated for two different charged states to well describe the electronic structure of the doped system.The EFG at the site of the phosphorous impurity in the charged supercell calculated with the exchange-correlation potential of the Wu-Cohen generalized gradient approximation(WC-GGA)is 0.573×10^(21) V/m^(2).Then,the nuclear quadrupole moment of the I=3 state in ^(28)P is deduced to be 137 mb from the quadrupole interaction frequency of 190 kHz measured recently by theβ-NQR method. | 张乔丽 袁大庆 张焕乔 范平 左翼 郑永男 K.Masuta M.Fukuda M.Mihara T.Minamisono A.Kitagawa 朱升云 | 2012 | Chinese Physics Letters2012，29，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员