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| 1 | A practical strategy to reduce the risk of passive hemolysis by screening plateletpheresis donors for high‐titer ABO antibodies显示文摘 | KarenQuillen Sherry L.Sheldon Jennifer A.Daniel‐Johnson A. HallieLee‐Stroka Willy A.Flegel | 2011 | Transfusion2011，，1： | 1 |
| 2 | Reproduction and beyond,kisspeptin in ruminants显示文摘Kisspeptin(Kp) is synthesized in the arcuate nucleus and preoptic area of the hypothalamus and is a regulator of gonadotropin releasing hormone in the hypothalamus.In addition,Kp may regulate additional functions such as increased neuropeptide Y gene expression and reduced proopiomelanocortin(POMC) gene expression in sheep.Other studies have found a role for Kp to release growth hormone(GH),prolactin and luteinizing hormone(LH)from cattle,rat and monkey pituitary cells.Intravenous injection of Kp stimulated release LH,GH,prolactin and follicle stimulating hormone in some experiments in cattle and sheep,but other studies have failed to find an effect of peripheral injection of Kp on GH release.Recent studies indicate that Kp can stimulate GH release after intracerebroventricular injection in sheep at doses that do not release GH after intravenous injection.These studies suggest that Kp may have a role in regulation of both reproduction and metabolism in sheep.Since GH plays a role in luteal development,it is tempting to speculate that the ability of Kp to release GH and LH is related to normal control of reproduction. | Joseph A.Daniel Chad D.Foradori Brian K.Whitlock James L.Sartin | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 0 |
| 3 | CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation显示文摘Autosomal dominant polycystic kidney disease(ADPKD)is characterized by progressive enlargement of fluid-filled cysts,causing nephron loss and a decline in renal function.Mammalian target of rapamycin(mTOR)is overactive in cyst-lining cells and contributes to abnormal cell proliferation and cyst enlargement;however,the mechanism for mTOR stimulation remains unclear.We discovered that calcium/calmodulin(CaM)dependent kinase IV(CaMK4),a multifunctional kinase,is overexpressed in the kidneys of ADPKD patients and PKD mouse models.In human ADPKD cells,CaMK4 knockdown reduced mTOR abundance and the phosphorylation of ribosomal protein S6 kinase(S6K),a downstream target of mTOR.Pharmacologic inhibition of CaMK4 with KN-93 reduced phosphorylated S6K and S6 levels and inhibited cell proliferation and in vitro cyst formation of ADPKD cells.Moreover,inhibition of calcium/CaM-dependent protein kinase kinase-βand CaM,two key upstream regulators of CaMK4,also decreased mTOR signaling.The effects of KN-93 were independent of the liver kinase B1-adenosine monophosphate-activated protein kinase(AMPK)pathway,and the combination of KN-93 and metformin,an AMPK activator,had additive inhibitory effects on mTOR signaling and in vitro cyst growth.Our data suggest that increased CaMK4 expression and activity contribute to mTOR signaling and the proliferation of cystic cells of ADPKD kidneys. | Yan Zhang Emily A.Daniel July Metcalf Yuqiao Dai Gail A.Reif Darren P.Wallace | 2022 | Journal of Molecular Cell Biology2022，14，7： | 0 |
| 4 | 得克萨斯州干盐湖区抑制牲畜废物所致地下水污染的有效性显示文摘得州南部高原地区的干盐湖位于地下水活跃补给 Ogalalla 含水层的部位,构成了市政和农业废物管理系统的一部分。关于干盐湖抑制牛奶厂污水的有效性已作了一些研究,分别在干盐湖的环形区和干湿交替区布置了4个取样孔,并且从这几个孔中采集了表面和下部的土样。在此区内牛奶厂的地表排泄物已进入了干盐湖。随后对这些钻孔取样作了包括硝酸盐氮、铵氮、pH 值、电导率和土壤结构的物理和化学分析。对两个钻孔剖面上的氯化物分布与硝酸盐进行了对比。研究结果表明,在干盐湖的干湿交替带重粘土底层上部2m 范围内,营养组分含量值增高,但在此深度以下就并非如此了。硝酸盐和氯化物分布情况的比较表明,脱硝化作用去除了干盐湖这一地带的大部分硝酸根,这也说明,一旦到达干盐湖中心区,硝酸盐便能经历足够长时间的被脱硝化作用。然而,在干盐湖的环形区内发现了氯化物的运移。此外,氯化物在干盐湖中心之下的分布特征,让人还担心存在来自干盐湖的氯化物的运移问题。 | John A.Daniel 李永敏 | 1998 | 地质科学译丛1998，15，3： | 0 |
| 5 | Timer Entrenched Baited Scheme to Locate and Remove Attacks in MANET显示文摘The Mobile Ad-hoc Network(MANET)is a dynamic topology that provides a variety of executions in various disciplines.The most sticky topic in organizationalfields was MANET protection.MANET is helpless against various threats that affect its usability and accessibility.The dark opening assault is considered one of the most far-reaching dynamic assaults that deteriorate the organi-zation's execution and reliability by dropping all approaching packages via the noxious node.The Dark Opening Node aims to deceive any node in the company that wishes to connect to another node by pretending to get the most delicate ability to support the target node.Ad-hoc On-demand Distance Vector(AODV)is a responsive steering convention with no corporate techniques to locate and destroy the dark opening center.We improved AODV by incorporating a novel compact method for detecting and isolating lonely and collaborative black-hole threats that utilize clocks and baits.The recommended method allows MANET nodes to discover and segregate black-hole network nodes over dynamic changes in the network topology.We implement the suggested method's performance with the help of Network Simulator(NS)-3 simulation models.Furthermore,the proposed approach comes exceptionally near to the original AODV,absent black holes in terms of bandwidth,end-to-end latency,error rate,and delivery ratio. | S.Padmapriya R.Shankar R.Thiagarajan N.Partheeban A.Daniel S.Arun | 2023 | Intelligent Automation & Soft Computing2023，，1： | 0 |
| 6 | Kernel-Based State-Space Kriging for Predictive Control显示文摘In this paper, we extend the state-space kriging(SSK) modeling technique presented in a previous work by the authors in order to consider non-autonomous systems. SSK is a data-driven method that computes predictions as linear combinations of past outputs. To model the nonlinear dynamics of the system, we propose the kernel-based state-space kriging(K-SSK), a new version of the SSK where kernel functions are used instead of resorting to considerations about the locality of the data. Also, a Kalman filter can be used to improve the predictions at each time step in the case of noisy measurements. A constrained tracking nonlinear model predictive control(NMPC) scheme using the black-box input-output model obtained by means of the K-SSK prediction method is proposed. Finally, a simulation example and a real experiment are provided in order to assess the performance of the proposed controller. | A.Daniel Carnerero Daniel R.Ramirez Daniel Limon Teodoro Alamo | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，5： | 0 |
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