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| 1 | 不同基因型戊型肝炎病毒重组蛋白的抗原性分析显示文摘目的 :探讨不同基因型和亚型戊型肝炎病毒 (HEV)重组蛋白氨基酸序列的变化对HEV抗原性的影响 ,筛选出最佳的HEV抗原用于戊型肝炎的免疫诊断。方法 :用已知序列的HEV基因工程表达蛋白作为包被抗原 ,对已知血清标本进行酶联免疫吸附试验测定。结果 :6种不同抗原对 3 0份正常献血者血清无抗原性 ,对 17份急性戊型肝炎病人血清和 5份实验感染动物血清均呈阳性反应 ,但血清抗体滴度的高低与所用抗原的基因型有关 ,尤其是受到该抗原第 76位氨基酸变化的影响。结论 | 孟继鸿 戴星 窦晓光 YE KHUDYAKOV H A FIELDS | 2002 | 东南大学学报(医学版)2002，21，1： | 30 |
| 2 | Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation显示文摘航线发炎是许多呼吸障碍的特点,例如气喘和膀胱的纤维变性。在发炎触发的航线基因表示的变化在这些疾病的致病起一个关键作用。基因连接研究建议 ESE-2 和 ESE-3,编码上皮特定的 Ets-domain-containing 抄写因素,是候选人气喘危险性基因。我们这里报导 et 家庭抄写因素 ESE-1 的另一个成员的表示,以及 ESE-3,起来在支气管的上皮的房间线由煽动性的 cytokines interleukin-1beta (IL-1beta ) 和肿瘤坏死 factor-alpha (TNF-alpha ) 调整了。有 IL-1beta 和 TNF-alpha 的这些房间的处理为 ESE-1 和 ESE-3 导致了信使 rna 表示的戏剧的增加。我们证明导致的表示被抄写因素 NF-kappaB 的激活调停。我们描绘了 ESE-1 和 ESE-3 倡导者并且识别了为导致 cytokine 的表达式被要求的 NF-kappaB 有约束力的序列。另外,我们也表明那 ESE-1 在上面调整 ESE-3 表示, down 由 cytokines 调整它的自己的正式就职。最后,我们在 Elf3 显示出那(对人的 ESE-1 相应) 猛烈老鼠,煽动性的 cytokine interleukin-6 (IL-6 ) 的表示是调整的 down。我们的调查结果建议 ESE-1 和 ESE-3 在航线发炎起一个重要作用。 | Jing Wu Rongqi Duan Huibi Cao Deborah Field Catherine M Newnham David R Koehler Noe Zamel Melanie A Pritchard Paul Hertzog Martin Post A Keith Tanswell Jim Hu | 2008 | Cell Research2008，18，6： | 6 |
| 3 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 4 | Abdominal obesity adversely affects bone mass in children显示文摘AIM To determine the effect of childhood obesity and insulin resistance on bone health. METHODS We conducted a cross sectional study in pubertal adolescents and young adults 13-20 years old who were either overweight/obese or normal weight. Participants were Tanner 3 or above for pubertal stage, and had fasting blood work done to measure glucose, insulin, C-reactive protein and lipid levels. Homeostatic model of insulin resistance(HOMA-IR) was calculated using the formula(Fasting Blood Glucose *Insulin/405). Body composition and bone mineral density were measured using dual energy X-ray absorptiometry(DXA; Hologic QDR 4500, Waltham, MA, United Kingdom). RESULTS Percent trunk fat was associated inversely with whole body bone mineral content(BMC), whereas HOMA-IR was associated positively with whole body BMC.CONCLUSION Our results suggest that abdominal adiposity may have an adverse effect on whole body bone parameters and that this effect is not mediated by insulin resistance. | Sowmya Krishnan Michael P Anderson David A Fields Madhusmita Misra | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 3 |
| 5 | Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer: preliminary results of the MRC randomised controlled surgical trial显示文摘 | A Cuschieri V Joypaul P Fayers P Cook J Fielding J Craven J Bancewicz | 1996 | The Lancet . 1996 (9007)1996，，： | 2 |
| 6 | Reliability-based approach to linear covariance control design 显示文摘 | Bergman L A | 1998 | Journal of Engineering Mechanics1998，124，2： | 1 |
| 7 | CT and ultrasound features of metanephric adenoma in adults with pathologic correlation显示文摘 | Visweswaran A Silverman SG | 1999 | J Comput Assist Tomogr1999，23，3： | 1 |
| 8 | The deter- minants of corporate board size and composition: an empirical analysis 显示文摘 | BOONE A FIELD L KARPOFF J | 2007 | Journal of Financial Economics2007，85，1： | 1 |
| 9 | Tensile and Fatigue Strength of Free-standing CVD Diamond显示文摘 | Daviesa A R Field J E Takahashi K | 2005 | Diamond and Related Materials2005，14，： | 1 |
| 10 | Enhancement effects on quality characteristics of pork derived from pigs of various commercial genetic backgrounds显示文摘 | Brewer M S Sosnicki A Field B | 2004 | Journal of Food Science2004，69，1： | 1 |
| 11 | Evaluation of electrostatically endothelial cell seeded expanded polytetrafluoroethylene grafts in a canine fem oral artery model显示文摘 | Fields C Cassano A Makhoul RG | 2002 | J Biomater Appl2002，17，2： | 1 |
| 12 | Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30 显示文摘 | Revankar C M Mitchell H D Field A S | 2007 | ACS Chem Biol2007，2，8： | 1 |
| 13 | Characterization of a novel manganese peroxidase?lignin peroxidase hybrid isozyme produced by Bjerkondera species strain BOS55 in the absence of manganese显示文摘 | Mester T Field J A | 1998 | Journal of Biological Chemistry1998，273，15： | 1 |
| 14 | Quantitative determi-nation of 1,4-dioxane and tetrahydrofuran in groundwater bysolid phase extraction GC/MS/MS显示文摘 | ISAACSON C MOHR T K FIELD J A | 2006 | Environmental Scienceand Technology2006，40，23： | 1 |
| 15 | An ap- proach to automatic three-dimensional finite element mesh generation显示文摘 | CAVENDISH J C FIELD D A FREY W H | 1985 | International Journal for Numerical Methods in Engineering1985，21，2： | 1 |
| 16 | What is 'emerging'? 显示文摘 | Field J A Johnson C A Rose J B | 2006 | Environmental Science & Technology2006，40，23： | 1 |
| 17 | Primary and repeat surgical treatment for female pelvic organ prolapse and incontinence in parous women in the UK: a register linkage study显示文摘 | Abdel-Fattah M Familusi A Fielding S | 2011 | BMJ Open2011，1，00： | 1 |
| 18 | A narrow-waveband spectral index that tracks diurnal changes in photosynthetic efficient显示文摘 | Gamon J A Penuelas J Field C B | 1992 | Remote Sensing of Environment1992，41，1： | 1 |
| 19 | The Effects of Cue-Specific Inhibition Training on Alcohol Consumption in Heavy Social Drinkers 显示文摘 | JONES A FIELD M | 2013 | Experimental and Clinical Psychopharmacology2013，21，1： | 1 |
| 20 | Nonlinear optical processes using electromagnetically induced transparency 显示文摘 | HARRIS S E FIELD J E IMAMOGLU A | 1990 | PHYSICAL REVIEW LETTERS1990，64，10： | 1 |
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